ID M3VUR8_FELCA Unreviewed; 841 AA.
AC M3VUR8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=G protein-coupled receptor 155 {ECO:0000313|Ensembl:ENSFCAP00000000406.4};
GN Name=GPR155 {ECO:0000313|Ensembl:ENSFCAP00000000406.4,
GN ECO:0000313|VGNC:VGNC:62680};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000406.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000406.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000406.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000406.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000406.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000406.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000406.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AANG04001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3VUR8; -.
DR Ensembl; ENSFCAT00000000439.6; ENSFCAP00000000406.4; ENSFCAG00000000439.6.
DR VGNC; VGNC:62680; GPR155.
DR eggNOG; ENOG502QQ69; Eukaryota.
DR GeneTree; ENSGT00390000004153; -.
DR HOGENOM; CLU_018490_0_0_1; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000000439; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd04443; DEP_GPR155; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR037368; GPR155_DEP.
DR InterPro; IPR004776; Mem_transp_PIN-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF5; INTEGRAL MEMBRANE PROTEIN GPR155; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF03547; Mem_trans; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 731..809
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 528..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 93447 MW; 35A5D70D3DDCF862 CRC64;
MNSFSNLPAE NLTIAVNMSK TFSSTVMHRF NSTNDPPSMS ITRLFPALLE CFGIVLCGYI
AGRANVITST QAKGLGNFVS RFALPALLFK NMVVLNFSNV DWSFLYSILI AKASVFFIVC
VLTLLVASPD SRFSKAGLFP IFATQSNDFA LGYPIVEALY QTTYPEYLQY IYLVAPISLM
MLNPIGFIFC EIQKWKDTQN ASQNKVKIVG LGLLRVLQNP IVFMVFIGIA FNFILDQKVP
VYMENFLDGL ANSFSGSALF YLGLTMVGKI KKLKKSAFIV LILLITAKLL VLPLLCREMV
ELLDKGDSVV NHTSLSNYAF LYGVFPVAPG VAIFATQFNM EVEIITSGMV ISTFVSAPIM
YVSAWLLTFP TMDPKPLAYA IQNVSFDISI ISLVSLSIVC AGMMIWNFVK EKNFVGQILV
FVLLYSSLYS TYLWTGLLAV SLFLLKKRES VQIPVGIIII SGWGIPALLV GVLLITGKHN
GDSIDSAFFY GKEQMIITAV TLFCSIVIAG ISLMCMNRTT QAGRYEGFDQ SQSHKAAEPG
NTTFEESPVP INDPEPFTSS IPETGCCSCS MGNGGLCCPS AEPVANTSTS GLVTPSSEKN
EHCVSRCNSQ SCMLVQEEEQ YLQSGDQQLA RHVLLCLLLI IGLFANLSSC LWWLFNQEPG
RLYVELQFFC AVFNFGQGFI SFGIFGLDKH LIILPFKRRL EFLWNNKDTT DNRGSPVPEE
IKMTCQQFIH YHRDLCIRNI VKERRCGAKT STGTFCGCDL VNWLIEVGLA SDRGEAVIYG
DRLVQGGVIQ HITNEYEFRD EYLFYRFLQK SPEQSPPAVN ANTPPQERYK EIEHSSPSPK
T
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