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Database: UniProt
Entry: M3VVD7_FELCA
LinkDB: M3VVD7_FELCA
Original site: M3VVD7_FELCA 
ID   M3VVD7_FELCA            Unreviewed;       431 AA.
AC   M3VVD7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=AP-3 complex subunit mu-1 {ECO:0000256|ARBA:ARBA00041150, ECO:0000256|PIRNR:PIRNR005992};
GN   Name=AP3M1 {ECO:0000313|Ensembl:ENSFCAP00000000719.3,
GN   ECO:0000313|VGNC:VGNC:67728};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000719.3, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000000719.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000719.3,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000000719.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000719.3,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000000719.3}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000719.3};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC       not clathrin-associated. The complex is associated with the Golgi
CC       region as well as more peripheral structures. It facilitates the
CC       budding of vesicles from the Golgi membrane and may be directly
CC       involved in trafficking to lysosomes. In concert with the BLOC-1
CC       complex, AP-3 is required to target cargos into vesicles assembled at
CC       cell bodies for delivery into neurites and nerve terminals.
CC       {ECO:0000256|ARBA:ARBA00025605}.
CC   -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC       of two large adaptins (delta-type subunit AP3D1 and beta-type subunit
CC       AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and
CC       a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with
CC       AGAP1. AP-3 associates with the BLOC-1 complex.
CC       {ECO:0000256|ARBA:ARBA00038709}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|PIRNR:PIRNR005992}.
CC       Cytoplasmic vesicle membrane {ECO:0000256|PIRNR:PIRNR005992};
CC       Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR005992};
CC       Cytoplasmic side {ECO:0000256|PIRNR:PIRNR005992}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       {ECO:0000256|ARBA:ARBA00005324, ECO:0000256|PIRNR:PIRNR005992}.
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DR   EMBL; AANG04000273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3VVD7; -.
DR   STRING; 9685.ENSFCAP00000000719; -.
DR   PaxDb; 9685-ENSFCAP00000000719; -.
DR   Ensembl; ENSFCAT00000000775.5; ENSFCAP00000000719.3; ENSFCAG00000000775.5.
DR   VGNC; VGNC:67728; AP3M1.
DR   eggNOG; KOG2740; Eukaryota.
DR   GeneTree; ENSGT00940000158184; -.
DR   HOGENOM; CLU_026996_6_2_1; -.
DR   InParanoid; M3VVD7; -.
DR   OMA; INVHFTI; -.
DR   Proteomes; UP000011712; Chromosome D2.
DR   Bgee; ENSFCAG00000000775; Expressed in embryonic head and 10 other cell types or tissues.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; IEA:Ensembl.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   CDD; cd09260; AP-3_Mu3A_Cterm; 1.
DR   CDD; cd14837; AP3_Mu_N; 1.
DR   Gene3D; 3.30.450.60; -; 1.
DR   Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR001392; Clathrin_mu.
DR   InterPro; IPR018240; Clathrin_mu_CS.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR028565; MHD.
DR   PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR   PANTHER; PTHR10529:SF342; AP-3 COMPLEX SUBUNIT MU-1; 1.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF005992; Clathrin_mu; 1.
DR   PRINTS; PR00314; CLATHRINADPT.
DR   SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR   SUPFAM; SSF64356; SNARE-like; 1.
DR   PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
DR   PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR005992};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW   ECO:0000256|PIRNR:PIRNR005992};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005992};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005992};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005992}.
FT   DOMAIN          189..430
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
SQ   SEQUENCE   431 AA;  48584 MW;  442FC1B8FEC07C37 CRC64;
     MYTKLFKLFS LQKMIHSLFL INCSGDIFLE KHWKSVVSQS VCDYFFEAQE KAADVENVPP
     VISTPHHYLI SIYRDKLFFV SVIQTEVPPL FVIEFLHRVA DTFQDYFGEC SEAAIKDNVV
     IVYELLEEML DNGFPLATES NILKELIKPP TILRSVVNSI TGSSNVGDTL PTGQLSNIPW
     RRAGVKYTNN EAYFDVVEEI DAIIDKSGST VFAEIQGVID ACIKLSGMPD LSLSFMNPRL
     LDDVSFHPCI RFKRWESERV LSFIPPDGNF RLISYRVSSQ NLVAIPVYVK HCISFKENSS
     CGRFDITIGP KQNMGKTIEG ITVTVHMPKV VLNMNLTPTQ GSYTFDPVTK VLTWDVGKIT
     PQKLPSLKGL VNLQSGAPKP EENPSLNIQF KIQQLAISGL KVNRLDMYGE KYKPFKGVKY
     VTKAGKFQVR T
//
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