ID M3VVQ4_FELCA Unreviewed; 2719 AA.
AC M3VVQ4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Filamin C {ECO:0000313|Ensembl:ENSFCAP00000000888.4};
GN Name=FLNC {ECO:0000313|Ensembl:ENSFCAP00000000888.4,
GN ECO:0000313|VGNC:VGNC:62293};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000888.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000888.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000888.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000888.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000888.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000888.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000888.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; AANG04000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000000888; -.
DR PaxDb; 9685-ENSFCAP00000020109; -.
DR Ensembl; ENSFCAT00000000954.5; ENSFCAP00000000888.4; ENSFCAG00000000954.5.
DR VGNC; VGNC:62293; FLNC.
DR GeneTree; ENSGT00940000153588; -.
DR HOGENOM; CLU_000783_0_0_1; -.
DR InParanoid; M3VVQ4; -.
DR OMA; YPVMAGK; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000000954; Expressed in embryo and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR CDD; cd21314; CH_FLNC_rpt2; 1.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 37..143
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 160..263
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 271..369
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 371..469
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 470..566
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 567..659
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 663..758
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 759..861
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 862..960
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 961..1056
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1057..1149
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1150..1244
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1245..1344
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1345..1437
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1438..1533
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1534..1630
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1643..1734
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1779..1848
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1848..1940
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1938..2027
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2030..2122
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2215..2300
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2303..2395
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2397..2490
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2494..2586
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2624..2718
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2176..2196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2233..2253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2177..2196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2233..2252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2719 AA; 290340 MW; 664003DCEBD18549 CRC64;
MMNNSSYSEA AGLGLGDEVD DMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH LKCVGKRLTD
LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN VSVALEFLER EHIKLVSIDS
KAIVDGNLKL ILGLIWTLIL HYSISMPMWE DEEDEDARKQ TPKQRLLGWI QNKVPQLPIT
NFNRDWQDGK ALGALVDNCA PGLCPDWEAW DPNQPVENAR EAMQQADDWL GVPQVIAPEE
IVDPNVDEHS VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPHG NTVLQPAHFT
VQTVDAGVGE VLVYIEDPEG HTEEAKVVPN NDKNRTYAVS YVPKVAGLHK VTVLFAGQNI
ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD IYTAGAGTGD VAVVIVDPQG
RRDTVEVALE DKGDSTFRCT YRPVMEGPHT VHVAFAGAPI TRSPFPVHVA EACNPNACRA
SGRGLQPKGV RVKEVADFKV FTKGAGSGEL KVTVKGPKGT EEPVKVREAG DGVFECEYHP
VVPGKYVVTI TWGGYAIPRS PFEVQVSPEA GAQKVRAWGP GLKTGQVGKS ADFVVEAIGT
EVGTLGFSIE GPSQAKIECD DKGDGSCDVR YWPTEPGEYA VHVICDDEDI RDSPFIAHIQ
PAAPDCFPDK VKAFGPGLEP TGCIVDKPAE FTIDRAAGKG DLNLYAQDAD GCPVNIMVIP
NGDGTFRCSY VPTKPIKHTI IISWGGVNVP KSPFRVNVGE GSHPERVKVY GPGVEKTGLK
ANEPTYFTVD CSEAGQGDVS IGIKCAPGVV GPAEADIDFD IIKNDNDTFT VKYTPPGAGR
YTIMVLFANQ EIPASPFHIK VDPSHDASKV KAEGPGLNRT GVEVGKPTHF TVLTKGAGKA
KLDVHFAGAA KGEAVRDFEI IDNHDYSYTV KYTAVQQGNM AVTVTYGGDP VPKSPFVVNV
APPLDLSKVK VQGLNSKVAV GQEQAFSVNT RGAGGQGQLD VRMTSPSRRP IPCKLEPGGG
AETQAVRYMP PEEGPYKVDI TYDGHPVPGS PFAVEGVLPP DPSKVCAYGP GLKGGLVGTP
APFSIDTKGA GTGGLGLTVE GPCEAKIECQ DNGDGSCAVS YLPTEPGEYT INILFAEAHI
PGSPFKATIR PVFDPSKVRA SGPGLERGKA GEAATFTVDC SEAGEAELTI EILSDAGVKA
EVLIHNNADG TYHITYSPAF PGTYTITIKY GGHPVPKFPT RVHVQPAVDT SGVKVSGPGV
EPHGVLREVT TEFTVDARSL TATGGNHVTA RVLNPSGAKT DTYVTDNGDG TYRVQYTAYE
EGVHLVEVLY DDVAVPKSPF RVGVTEGCDP TRVRAFGPGL ESGLVNKANH FTVETRGAGT
GGLGLAIEGP SEAKMSCKDN KDGSCTVEYI PFTAGDYDVN ITFGGRPIPG SPFRVPVKDV
VDPGKVKCSG PGLGAGVRAR VPQTFTVDCS QAGRAPLQVA VLGPTGVAEP VEVRDKGDGT
HTVHYTPATD GPYTVAVKYA DQEVPRSPFK IKVLPAHDAS KVRASGPGLN ASGIPASLPV
EFTIDARDAG EGLLTVQILD PEGKPKKANI RDNGDGTYTV SYLPDMSGRY TITIKYGGDE
IPYSPFRIHA LPTGDASKCL VTVSIGGHGL GACLGPRIQI GEETVITVDA KAAGKGKVTC
TVSTPDGAEL DVDVVENHDG TFDIYYTAPE PGKYVITIRF GGEHIPNSPF HVLACDPMPH
VEEPPDVLQP HRPGPYPTHW ATEEPVVPVE PMESMLRPFN LVIPFTVQKG ELTGEVRMPS
GKTARPNITD NKDGTITVRY APTEKGLHQM GIKYDGNHIP GSPLQFYVDA INSRHVSAYG
PGLSHGMVNK PATFTIVTKD AGEGGLSLAV EGPSKAEITC KDNKDGTCTV SYLPTAPGDY
SIIVRFDDKH IPGSPFTAKI TGDDSMRTSQ LNVGTSTDVS LKITESDLSL LTASIRAPSG
NEEPCLLKRL PNRHIGISFT PKEVGEHVVS VRKSGKHVTN SPFKILVGPS EIGDASKVRV
WGKGLSEGHT FQVAEFIVDT RNAGYGGLGL SIEGPSKVDI NCEDMEDGTC KVTYCPTEPG
TYIINIKFAD KHVPGSPFTV KVTGEGRMKE SITRRRQAPS IATIGSTCDL NLKIPGNWFQ
MVSAQERLTR TFTRSSHTYT RTERTEISKT RGGETKREVR VEESTQVGGD PFPAVFGDFL
GRERLGSFGS ITRQQEGEAS SQDMTAQVTS PSGKMEAAEI VEGEDSAYSV RFVPQEMGPH
TVTVKYRGQH VPGSPFQFTV GPLGEGGAHK VRAGGTGLER GVAGVPAEFS IWTREAGAGG
LSIAVEGPSK AEISFEDRKD GSCGVSYVVQ EPGDYEVSIK FNDEHIPDSP FVVPVASLSD
DARRLTVTSL QETGLKVNQP ASFAVQLNGA RGVIDARVHT PSGAVEECYV SELDSDKHTI
RFIPHENGVH SIDVKFNGAH IPGSPFKIRV GEQSQAGDPG LVSAYGPGLE GGTTGVSSEF
IVNTLNAGSG ALSVTIDGPS KVQLDCRECP EGHVVTYTPM APGNYLIAIK YGGPQHIVGS
PFKAKVTGPR LSGGHSLHET STVLVETVTK SSSSRGSSYS SIPKFSSDAS KVVTRGPGLS
QAFVGQKNSF TVDCSKAGTN MMMVGVHGPK TPCEEVYVKH MGNRVYNVTY TVKEKGDYIL
IVKWGDESVP GSPFKVNVP
//
