ID M3VZ73_FELCA Unreviewed; 699 AA.
AC M3VZ73;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Discs large MAGUK scaffold protein 4 {ECO:0000313|Ensembl:ENSFCAP00000002598.6};
GN Name=DLG4 {ECO:0000313|Ensembl:ENSFCAP00000002598.6,
GN ECO:0000313|VGNC:VGNC:61512};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000002598.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000002598.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002598.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000002598.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002598.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000002598.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002598.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019672645.1; XM_019817086.1.
DR AlphaFoldDB; M3VZ73; -.
DR Ensembl; ENSFCAT00000002824.6; ENSFCAP00000002598.6; ENSFCAG00000002824.6.
DR GeneID; 101093902; -.
DR CTD; 1742; -.
DR VGNC; VGNC:61512; DLG4.
DR eggNOG; KOG0708; Eukaryota.
DR GeneTree; ENSGT00940000157956; -.
DR HOGENOM; CLU_001715_4_2_1; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000002824; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12030; SH3_DLG4; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 40..127
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 135..222
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 288..369
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 403..473
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 509..684
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 699 AA; 77460 MW; BC39EBF2B91144EF CRC64;
MDCLCIVTTK ANSPPVIVNT DTLEAPGYVN GTEGEMEYEE ITLERGNSGL GFSIAGGTDN
PHIGDDPSIF ITKIIPGGAA AQDGRLRVND SILFVNEVDV REVTHSAAVE ALKEAGSIVR
LYVMRRKPPA EKLMEIKLIK GPKGLGFSIA GGVGNQHIPG DNSIYVTKII EGGAAHKDGR
LQIGDKILAV NSVGLEDVMH EDAVAALKNT YDVVYLKVAK PSNAYLSDSY APPDITTSYS
QHLDNEISHS SYLGTDYPTA MTPTSPRRYS PVAKDLLGEE DVPREPRRIV IHRGSTGLGF
NIVGGEDGEG IFISFILAGG PADLSGELRK GDQILSVNGV DLRSASHEQA AIALKNAGQT
VTIIAQYKPE EYSRFEAKIH DLREQLMNSS LGSGTASLRS NPKRGFYIRA LFDYDKTKDC
GFLSQALSFR FGDVLHVLDA SDEEWWQARR VHPDSEADDI GFIPSKRRVE RREWSRLKAK
DWGSSSGSQG REDSVLSYET VTQMEVHYAR PIIILGPTKD RANDDLLSEF PDKFGSCVPH
TTRPKREYEI DGRDYHFVSS REKMEKDIQA HKFIEAGQYN SHLYGTSVQS VREVAEQGKH
CILDVSANAV RRLQAAHLHP IAIFIRPRSL ENVLEINKRI TEEQARKAFD RATKLEQEFT
ECFSAIVEGD SFEEIYHKVK RVIEDLSGPY IWVPARERL
//
