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Database: UniProt
Entry: M3VZU4_FELCA
LinkDB: M3VZU4_FELCA
Original site: M3VZU4_FELCA 
ID   M3VZU4_FELCA            Unreviewed;      2009 AA.
AC   M3VZU4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSFCAP00000002913};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000002913, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000002913, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002913,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000002913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002913};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000002913}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002913};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AANG03347399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03347400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000002913; -.
DR   Ensembl; ENSFCAT00000003163; ENSFCAP00000002913; ENSFCAG00000003161.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3VZU4; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C2.
DR   Bgee; ENSFCAG00000003161; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    230    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    717    735       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    747    768       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    774    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    819    852       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    872    889       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    909    932       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1200   1219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1240   1256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1268   1289       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1317   1343       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1439   1465       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1524   1542       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1554   1572       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1584   1604       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1641   1669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1744   1767       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      478    666       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      717    936       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      946   1195       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1199   1473       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1523   1777       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      413    444       {ECO:0000256|SAM:Coils}.
FT   COILED      949    969       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2009 AA;  226851 MW;  593B868B7EDE48D9 CRC64;
     MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE APRPQLDLQA
     SRKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPI
     RRAAVKILVH SYPFMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV
     WKSLDHYLND PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW
     AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN
     QATIAETEEK EKRFQEAMEM LKKEHEALAI RGVDTVSHSS LEMSPLAPVT HERRRKRSKR
     MSSGTEECGD DRFPKSDSED GPRATNRLSS AHGLSRTSVK PRSSRGSIFT FRRRDLGSET
     DFADDENSTA GDSESHRTSL LVPWPLRRPS AQGQPSPGTS ALSHALNGKR NSTVDCNGVV
     SLLGTGDPEA TSPGSRLLRP VILDRPPDTT TPSEEPGRPQ MLYPQAPRAD GFEGPGERQR
     ALSAVSVLTS ALEELEESHR KCPPCWTRFA QRYLIWECCP LWMSIKQRVK FMVMDPFADL
     TITMCIVLNT LFMALEHYNM TTEFEEMLQV GNLVFTGIFT AEMTFKIIAL DPYYYFHIIV
     ILSLMELGLS RMGNLSVLRS FRLLRVFKLA KSWPTLNTLI KIIGNSVGAL GNLTLVLAII
     VFIFAVVGMQ LFGKNYSELR HRISDSGLLP RWHMMDFFHA FLIIFRILCG EWIETMWDCM
     EVSGQSLCLL VFLLVMVIGN LVVLNLFLAL LLSSFSADNL TAPDDDGEMN NLQLALARIQ
     RGLRFLKRTT WDFCCGLLQR RPQKPAALAA HGQLPRCVAT SSSPPPPPPE PEKAPPARKE
     TRFEEDKRPG QGTPGDTEPV CVPIAVAESD TDEQEEEEEN SLGTEEESSK QQESQPVSGS
     PEALPKPRAW SQVSETPSSE AEASVAQADW RQQRRVEPPA PGCSETQEDS YSEGSTADMT
     NTADLLEQIP DLGEDVKDPE DCFTEGCVRR CPCCAVDTTQ APGKVWWRLR KTCYRIVEHS
     WFETFIIFMI LLSSGALAFE DIYLEERKTI KVLLEYADKM FTYVFVLEML LKWVAYGFKK
     YFTNAWCWLD FLIVDVSLIS LVANTLGFAE MGPIKSLRTL RALRPLRALS RFEGMRVVVN
     ALVGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFGRCIN QTEGDLPLNY TIVNNKSDCE
     SFNVTGELYW TKVKVNFDNV GAGYLALLQV ATFKGWMDIM YAAVDSRGFE EQPQWEYNLY
     MYIYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKIRGQDI FMTEEQKKYY NAMKKLGSKK
     PQKPIPRPLN KYQGFLFDIV TKQAFDVTIM FLICLNMVTM MVETDDQSPE KVNILAKINL
     LFVAIFTGEC IIKMAALRHY YFTNSWNIFD FVVVILSIVG TVLSDIIQKY FFSPTLFRVI
     RLARIGRILR LIRGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYSIFG MANFAYVKWE
     AGIDDMFNFQ TFANSMLCLF QITTSAGWDG LLSPILNTGP PYCDPNLPNS NGSRGNCGSP
     AVGILFFTTY IIISFLIVVN MYIAIILENF SVATEESTEP LSEDDFDMFY EIWEKFDPEA
     TQFIEYSALS DFADALSEPL RIAKPNQISL INMDLPMVSG DRIHCMDILF AFTKRVLGES
     GEMDALKIQM EEKFMAANPS KISYEPITTT LRRKHEEVSA TVIQRAFRRH LLQRSMKHAS
     FLFRQQAGSS GLSEEDAPEQ EGLIAHVMNE NFSRRRGPPS TSSTSSPPSY DSVTRATSDN
     PQVRVSDCSR SEDLADFPAS PDRDRESIV
//
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