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Database: UniProt
Entry: M3VZU6_FELCA
LinkDB: M3VZU6_FELCA
Original site: M3VZU6_FELCA 
ID   M3VZU6_FELCA            Unreviewed;      1969 AA.
AC   M3VZU6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 47.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSFCAP00000002915};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000002915, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000002915, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002915,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000002915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002915};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000002915}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000002915};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AANG03347402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03347403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03347404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000002915; -.
DR   Ensembl; ENSFCAT00000003166; ENSFCAP00000002915; ENSFCAG00000003166.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3VZU6; -.
DR   OMA; WNIFDCI; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C2.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086043; P:bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    385    412       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    707    729       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    796    816       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    879    902       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1165   1183       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1204   1220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1232   1251       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1296   1316       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1367   1387       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1407   1430       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1480   1503       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1523   1541       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1553   1572       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1608   1636       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1711   1734       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    418       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      678    906       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      916   1159       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1163   1438       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1488   1744       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       30     50       {ECO:0000256|SAM:Coils}.
FT   COILED      409    443       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1969 AA;  221655 MW;  9B10ADCB66DACA87 CRC64;
     MAFPFGSLET TNFRRFTPES LVEIEKRITA KQAAKKAKDK HREQKDQEEK PRPQLDLKAC
     NQLPKFYGDL PAELVGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS YPLWFSLFIT VTILVNCVGM TQTELPERIE YVFTVIYTFE ALIKILARGF
     CLNEFAYLRD PWNWLDFSVI TLAYIGEAID LRGISGLRTF RVLRALKTVS VIPGLKVIVG
     ALIHSVKKLA DVTILTVFCL SVFALVGLQL FKGNLKNKCV KNCTALNETG NYSSYGKHEW
     NFCQEDEDFY YNKPGTSDPL LCGNGSDAGH CPEGYFCLKT SDNPDFNYTS FDSFAWAFLS
     LFRLMTQDSW ERLYQQTLRA SGKMYMVFFV LVIFLGSFYL VNLILAVVTM AYEEQNQATI
     DEIEAKEKKF QEALEMLRKE QEVLAALGID SASLHSHNGS PLASKTASER MPRMKPRVSE
     GSTDDSKSPQ SDPYNQRRMS FLGLTSGRRR ASHGSVFHFR APCLDASFPD GATDDGVFPG
     DRDSRRGSLL LGGGAGQQGP LPRSPLPQPS NPGSGLGEDG HSTLPTGELA PGGIEVSAFD
     AGQKKTFLSA EYLNEPFRAQ RAMSVVSIMT SVLEEFEESE RRCPPCLTSL AKKYLIWECC
     PTWVKLKTLL FGIVTDPFAE LTITLCIVVN TVFMAMEHHR MSPAFEAMLQ IGNIVFTVFF
     TAEMVFKIIA FDPYYYFQKR WNIFDCIIVT VSLIELGAAK KGSLSVLRTF RLLRVFKLAK
     SWPTLNTLIK IIGNSVGALG NLTIILAIIV FVFALVGKQL LGDNYRDNRH NISAPNEEWP
     RWHMHDFFHS FLIVFRILCG EWIENMWACM EVGQKSICLI LFLTVMVLGN LVVLNLFIAL
     LLNSFSADNL TAPDEDGEVN NLQMALARIQ AFGHRTRKAL CSFFSRPRLL PWPKAEPQLA
     VKLPLSSAKA ENHIAPDVAT GSPEGLPEPP GPRVNHSDFI TNPSIWVSVP IAEGESDLDD
     LEEDGEEDGE EDDEEVTPQE QQEQPQQVGR YEDHMAPRSP GSGMSSEDLA PHLGEKWKDE
     SAARGPAEGV DDTSSSEGST VDCLDPEEIL KKIPELADDL EEPDDCFTEG CIHHCPCCKV
     DAGKFPWAVG WQVRKACYRI VEHSWFESFI IFMILLSSGS LAFEDYYLDQ KPTVKALLEY
     TDRVFTFIFV FEMLLKWVAY GFKKYFTNAW CWLDFLIVNI SLTSLIAKIL QYSDVASIKA
     LRTLRALRPL RALSRFEGMR VVVDALVGAI PSIMNVLLVC LIFWLIFSIM GVNFFAGKFG
     RCVNKTNENL SLVPLSIVNN MSDCKDQNHT GSFFWVNMKV NFDNVAMGYL ALLQVATFKG
     WMDIMYAAVD SRDVNLQPKW EDNVYMYLYF VIFIIFGGFF TLNLFVGVII DNFNQQKKKI
     RGQDIFMTEE QKKYYNAMKK LGSKKPQKPI PRPLNKYQGF VFDVVTRQAF DIIIMVLICL
     NMITMMVETD DQSEEKTKIL NKVNQFFVAV FTGECVMKVF ALRHYYFTNG WNVFDFIVVV
     LSIGSLVFSA ILTSLENYFS PTLFRVIRLA RIGRILRLIR AAKGIRTLLF ALMMSLPALF
     NIGLLLFLVM FIYSIFGMAS FPHVRWEAGI DDMFNFQTFA NSMLCLFQIT TSAGWDGLLS
     PILNTGPPYC DPNLPNSNGS RGNCGSPAVG ILFFTTYIII SFLIVVNMYI AVILENFNVA
     TQESSEPLSE DDFDMFYETW EKFDPEATQF ITFSALSDFA DTLSGPLRIP KPNQNILIQM
     DLPLVPGDKI HCLDILFAFT KNVLGESGEL DSLKANIEEK FMATNVSKAS YEPIATTLRW
     KQEDISATVI QKAYRSYVLH RSKTISSPPG VPRAEEEAVS PQDEAFVGFM ANENCALPDK
     SESVSAVSFP PSYDSVTRGL SDQVNMSTSS SMQNEDEATS KKATAPGPE
//
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