ID M3W098_FELCA Unreviewed; 967 AA.
AC M3W098;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Carnosine synthase 1 {ECO:0000313|Ensembl:ENSFCAP00000003132.5};
GN Name=CARNS1 {ECO:0000313|Ensembl:ENSFCAP00000003132.5,
GN ECO:0000313|VGNC:VGNC:81911};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003132.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000003132.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003132.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000003132.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003132.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000003132.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003132.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W098; -.
DR STRING; 9685.ENSFCAP00000003132; -.
DR Ensembl; ENSFCAT00000003394.5; ENSFCAP00000003132.5; ENSFCAG00000003394.5.
DR VGNC; VGNC:81911; CARNS1.
DR eggNOG; ENOG502QRI6; Eukaryota.
DR GeneTree; ENSGT00390000018717; -.
DR HOGENOM; CLU_315906_0_0_1; -.
DR InParanoid; M3W098; -.
DR OMA; PISCFPG; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000003394; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0047730; F:carnosine synthase activity; IBA:GO_Central.
DR GO; GO:0102102; F:homocarnosine synthase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0035499; P:carnosine biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR041472; BL00235/CARNS1_N.
DR InterPro; IPR031046; CARNS1.
DR PANTHER; PTHR48066; CARNOSINE SYNTHASE 1; 1.
DR PANTHER; PTHR48066:SF1; CARNOSINE SYNTHASE 1; 1.
DR Pfam; PF18130; ATPgrasp_N; 1.
DR Pfam; PF15632; ATPgrasp_Ter; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 656..860
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 967 AA; 103898 MW; 84355B940DD1B100 CRC64;
MCPLPTLPKT HHFCPSQLSL DPLGPAWDCP LASKDLEEEE GPWGGGAGLP PPGCFSGSWR
HDVGLDCKGS LEEAEARAWT VYHYSLLQSC LQQAGLPETQ DRSQVPRTGC PGAEVTLCIL
GSPSTFLSVL LEGGVQSPGN MLLCLSPAWL MKVPAPGQPG ESALLVSKAV SFYPGGLTFL
DDFVPPRRAT YFLAGLGLGP GRGREAAELA RDLTCPTGAS AELARLLEDR LLTRRLLAQQ
GGVAVPATLA FTYKPPALLR VGDASPGLRL VELSGKEGQE TLVKEEVEAF LHSEALGDAL
QVAVKLSGWR WRGRQALRLY SRKELGTVVD MVLALLEKLE EEESVLVEAV CPPARLPFPG
SPPPGPELAV RICAVVCRTQ GDRPLLSKVV CSVGREDRPL RHRSSLPQTL EVALARCGLG
EATQVAVVRR RVKAAAEAAL AAVLALEAGL SAEQRGGRRA RTDFLGVDFA LTVADRALTP
VALELNGGLC LEACGALEGL WAAQRSQPAA REAAAAPLVE TMLRRSAHCL MEGKQLLLIG
AGGVSKKFVW EAARDYGLKL HLVESDPNHF ASQLVQTFIH FDVTEHRRDE ENARLLAELV
RARGLQLDGC FSYWDDCLVL TALLCQELGL PCSPPAAMRL AKQKSCTQLH LLRCHGPPWP
APSLHAVPCC PLESEADVER AVRQVPLPGV MKLEFGAGAV GVRLVEDAPQ CHEHFSRITR
DLQGEADHPG IGLGWGNAML LMEFIEGTEH DVDLVVYGGR LLAAFVSDNG PTRLPGFTET
AACMPTGLAP EQEAQLVQAA FRCCLGCGLL DGVFNVELKL TRAGPKLIEI NPRMGGFYLR
DWILELYGVD LLLAAAMVAC GLRPALPSHP RARGHLVGVM CLASQHLQAL SSTASRETLQ
ALHDQGLLRF NLLEEVLVPG EYEEPYCSVA CAGPSLAEAR LRLLGLCQGL GIDGPHYPVA
HFLSHFK
//
