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Database: UniProt
Entry: M3W0G7_FELCA
LinkDB: M3W0G7_FELCA
Original site: M3W0G7_FELCA 
ID   M3W0G7_FELCA            Unreviewed;      1880 AA.
AC   M3W0G7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSFCAP00000003234};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003234, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000003234, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003234,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000003234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003234};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000003234}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003234};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AANG03014699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03014700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000003234; -.
DR   Ensembl; ENSFCAT00000003505; ENSFCAP00000003234; ENSFCAG00000003505.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3W0G7; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome E1.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    172    193       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    276    293       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    299    319       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    463    491       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    619    637       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    649    672       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    684    708       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    729    757       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    816    842       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1075   1093       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1114   1136       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1142   1162       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1191   1217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1312   1338       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1397   1415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1427   1445       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1457   1477       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1514   1542       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1615   1641       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      177    496       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      620    846       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      856   1069       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1073   1346       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1396   1651       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      498    532       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1880 AA;  212492 MW;  E0D640A24014C9B8 CRC64;
     MASSSLPTLV PLGPESLRPF TRESLAAIER RAVEEEARQQ RNKQMEIEEP ERKPRSDLEA
     GKSLPLIYGD PPPEVIGIPL EDLDPYYSDK KTFIVLNKGK AIFRFSATPA LYMLSPFSII
     RRGAIKVLIH SYPAQMEREQ GHEGVGDGQS QVLWVRRPSV HLPSPPAPSL SLTLPLTLFS
     MFIMITILTN CVFMTMSDPP SWSKHVEYTF TGIYTFESLI KMLARGFCID DFTFLRDPWN
     WLDFSVIMMA YLTEFVDLGN ISALRTFRVL RALKTITVIP GLKTIVGALI QSVKKLSDVM
     ILTVFCLSVF ALVGLQLFMG NLRHKCVRWP PPFNDTNTTW YGNDTWYGNE TWYGNETWYG
     NETWTGHESW ASNYTFDWDA YINDEGNFYF LEGANDALLC GNSSDAGHCP EGYECIKAGR
     NPNYGYTSYD TFSWAFLALF RLMTQDYWEN LFQLTLRAAG KTYMIFFVVI IFLGSFYLIN
     LILAVVAMAY AEQNEATLAE DQEKEEEFQQ MLEKFKKQQE ELEKAKAAQA LEGGEADGDP
     AHGKDCNGSL DTSLGEKGPP RQSCSADSGI SDAMEELEEA HQKCPPWWYK CAHKVLIWNC
     CTPWVKFKNI IHLIVMDPFV DLGITICIVL NTLFMAMEHY PMTEEFDNVL TVGNLVFTGI
     FTAEMVLKLI ALDPYEYFQQ GWNIFDSIIV TLSLVELGLA NVQGLSVLRS FRLLRVFKLA
     KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ LFGKSYKECV CKIAADCSLP
     RWHMHDFFHS FLIVFRILCG EWIETMWDCM EVAGQAMCLT VFLMVMVIGN LVVLNLFLAL
     LLSSFSADSL AASDEDGEMN NLQIAIGRIK WGIGFAKAFL LGLLRGKILS PKEIMLSLGG
     PEEAGAAEEA GESASEDEKK EPPPEEDDKD LKKDNHILSH VGLVDGSPPS IELDHLNFIN
     NPYLTIHVPI ASEESDLEMP TEEDTDTFSE PEDGKQPPQP LDGNSSVCST ADYKPPEEDP
     EEQAEENPEG EQPEECFTEA CVQRCPFLYV DISQGRGKMW WTLRRACFKI VEHNWFETFI
     VFMILLSSGA LAFEDIYIEQ RRTIRTILEY ADKVFTYIFI LEMLLKWVAY GFKVYFTNAW
     CWLDFLIVDV SIISLVANWL GYSELGPIKS LRTLRALRPL RALSRFEGMR VVVNALLGAI
     PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY YCINTTTSER FDVSEVNNKS ECESLMHTGQ
     VRWLNVKVNY DNVGLGYLSL LQVATFKGWM DIMYAAVDSR EKEEQPQYEV NIYMYLYFVI
     FIIFGSFFTL NLFIGVIIDN FNQQKKKFGG KDIFMTEEQK KYYNAMKKLG SKKPQKPIPR
     PQNKIQGMVY DCVTKQVFDI TIMILICLNM VTMMVETDDQ SQLKVDILYN INMVFIIIFT
     GECVLKMLAL RQYYFTVGWN IFDFVVVILS IVGLALSDLI QKYFVSPTLF RVIRLARIGR
     VLRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYS IFGMSNFAYV KKESGIDDMF
     NFETFGNSII CLFEITTSAG WDGLLNPILN SGPPDCDPTL ENPGTSVRGD CGNPSIGICF
     FCSYIIISFL IVVNMYIAII LENFNVATEE SSEPLGEDDF EMFYETWEKF DPDATQFIAY
     SRLSDFVDTL QEPLRIAKPN KIKLITLDLP MVPGDKIHCL DILFALTKEV LGDSGEMDAL
     KETMEEKFMA ANPSKVSYEP ITTTLKRKHE EVCAIKIQRA YRRHLLQRTV KQASYMYRHS
     QDGSGDGGPE KEGLIANTMS KMYGHENGNS SVQSTGEEKG STGDSGPSIG LTPISPSDAA
     LPPSPSPGQT VRPGVKESLV
//
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