ID M3W0Z5_FELCA Unreviewed; 710 AA.
AC M3W0Z5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Zinc finger protein 276 {ECO:0000313|Ensembl:ENSFCAP00000003498.6};
GN Name=ZNF276 {ECO:0000313|Ensembl:ENSFCAP00000003498.6};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003498.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000003498.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003498.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000003498.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003498.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000003498.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003498.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W0Z5; -.
DR STRING; 9685.ENSFCAP00000003498; -.
DR PaxDb; 9685-ENSFCAP00000003498; -.
DR Ensembl; ENSFCAT00000003795.6; ENSFCAP00000003498.6; ENSFCAG00000003794.6.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158841; -.
DR HOGENOM; CLU_040755_0_0_1; -.
DR InParanoid; M3W0Z5; -.
DR OMA; LAVKWAW; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000003794; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF120; KRUEPPEL-LIKE FACTOR 15; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF07776; zf-AD; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS51915; ZAD; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 182..268
FT /note="ZAD"
FT /evidence="ECO:0000259|PROSITE:PS51915"
FT DOMAIN 569..599
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 600..627
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 628..655
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 658..686
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..436
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 184
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 187
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 241
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 244
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
SQ SEQUENCE 710 AA; 76349 MW; 76A4BC49226BAF0C CRC64;
MRARSRTGPN GAERRRRAET SERSPAELTR GSGPSGTYPG LAAQPTERGR AEPSGAELGR
IGSSGAERGR AEPSRAEPCP AGLSGAERRA RAVAAAAAMK RDRLGRFLSP GTAGQRGGSG
GGGGGACGSG RTRGRPARSG PSVDEAAALV AARLGWGLAR ARGDTGEDGA DEAGTGRALA
MGHCRLCHGK FSSRSLRSIS GRAPGESADR PPPGEPVFIR DFQHLLGVAV HQDPALSQFV
CKNCHAQFYQ CHGLLKSFLQ RVNVSPAGHR KTCTKVGAQP PPGAEEGACL VDLITSSPQG
LRDLVAWVHG HAASCGALPS LQRTLSSEYC GVIQAVWGCD QGHDYTMDAD SSCGALLLDS
ALAVKWTWDK EMAPWLTQHR GSNPTGAAPQ SSQGRATTTP AETETLPGAD AAPPPSDVNP
VGPGLCPPPQ PSFPPSGAPG RLGEKQVPSS TSDDRVKDEF SDLSEGDILS EDENDKKQST
QSSDESFDPY PEKKVSGKKS ESKEAKKAEE PKMRKKPGPK PGWKNKLRCE REELPTIYKC
PYQGCTAVYR GADGMKKHIK EHHEEVRERP CPHPGCNKVF MIDRYLQRHV KLIHTEVRNY
ICDECGQTFK QRKHLLVHQM RHSGAKPLQC EVCGFQCRQR ASLKYHMTKH KAETELDFAC
DQCGRRFEKA HNLNVHMSMV HPLTQTQDKA LPLEPPCGTT EGQAVKPEPT
//
