ID M3W1I7_FELCA Unreviewed; 1298 AA.
AC M3W1I7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSFCAP00000003761.6};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSFCAP00000003761.6,
GN ECO:0000313|VGNC:VGNC:61990};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000003761.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000003761.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003761.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000003761.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003761.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000003761.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000003761.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000003761; -.
DR PaxDb; 9685-ENSFCAP00000003761; -.
DR Ensembl; ENSFCAT00000004076.6; ENSFCAP00000003761.6; ENSFCAG00000004075.6.
DR VGNC; VGNC:61990; EVC2.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR InParanoid; M3W1I7; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000004075; Expressed in uterus and 11 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1298
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023852417"
FT REGION 30..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1150..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 450..480
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1154..1172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1298 AA; 145108 MW; 7041544DC6007EA9 CRC64;
MGAAGAAGSA TWVLAGGLLA AALAPPAGPG GRGRLPAGPG PLGRPLGRQR PPGLPAAPGA
GPERTAQDLP HLIWPNVESS RLKTEGGAPF GRKFSRKSEV FNPLLASAAS SEPWTPSTLA
FNPSGPKKTL SKRESPITQR VYGDISRDVQ GTAEDGVIFQ KCAVVSGQSE MQTAQVRLLV
VNAGTPVATN LSDLLLLDNI TGLSVRGSTG NRTSAGFQAF RKKFLQVGDS FSVSYTASIQ
AGEIGSGDVL MLPAWLTFQS SAPNRTQLKA LLTITAEEKI KVVPNHGLHA AGFFIASIAS
FVLTWATLFF TARYQCLKGS LITRHQVQHH ESKLEYSQFA SANGINEDLA LNDQMIDILS
SEDPGSMLQA LEELEIATLN RADSALEACR TQISRDIIAL LLKHLTSAGH LSPQVERRMG
SVFKTQFLLL EEIREEYDRK MVALTAECDL ETRKKTENQY QREMAAMEEA EELLKRVSEK
WAVECNGLLR TLHGLEQEHL RRSLALQQEE DFAKAHRQLA IFQRNELHNI FFTQIQSAVF
QGELKPEAAK TLLQDYSIQE KLEELMDFFQ ASKRYHLSKR FGHREYLVQN MQSSETRVQG
LLSAADTQLT VFIQKHERAG YLDEDQMEAL LQRTQTEVFS IKQKLDNDLK QEKKKLCQKL
ILKRRREILQ KHKEQQKELL SVGEALRAAE DAGQFLGRWG SLLAEHSAAL EALQERLDQA
ALEDLRALTL SLSEKATEEL RRLQSSGVAQ ELLKHGVPWL FLQQILEEHG RELAARARQL
EAEERDRDQE GVQSVRRRLK DDAPEASTEE QAELRRWEHL IFAKLCSSSF SQSEEELLRM
RQEVHGCFAQ MDRSLALPKI RARVLLQQFQ TAWREAEFQK LDQALAAPEM QQQSKARKPR
SKSKSKTDLL RKCIEDKIQL FEEQAPEDLV EKVRGELLRE RVQHLEAQEA RFAESLASLQ
FQKAARIAKT LWAYTALLSV QDLLLEELSE SETLTKLACE QILGSHSPEL QELGRKLEGR
LANQEAAQLQ RALASRQQWA GDGPGLLNEP EDADSDRQVS AVLQQALGKG RKLLEHQQQS
WREERDHSVV LEDLLENMEF DTFTTLYSQE LRLASYLSRL AMVPGGTLRR LLSVALPTAS
PAELLAALDS GSQKHPDHSA ENDAGGEQAD LGRKGKHQGW WQALESRLRG ELISRGLEKM
LWARERKESI LRKPCPPLRE RAALPGKGSW PHLSLESVGE VAAVPIVGAE AIDLLNTGEK
LFIFRNPKEP EISLHFPPRR KKKNFLNAKK ATWALGLD
//