ID M3W286_FELCA Unreviewed; 678 AA.
AC M3W286;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Numb-like protein {ECO:0000256|PIRNR:PIRNR017607};
GN Name=NUMBL {ECO:0000313|Ensembl:ENSFCAP00000004125.4,
GN ECO:0000313|VGNC:VGNC:68597};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000004125.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000004125.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004125.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000004125.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004125.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000004125.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004125.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR017607}.
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DR EMBL; AANG04000747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W286; -.
DR STRING; 9685.ENSFCAP00000004125; -.
DR PaxDb; 9685-ENSFCAP00000004125; -.
DR Ensembl; ENSFCAT00000004469.6; ENSFCAP00000004125.4; ENSFCAG00000004467.6.
DR VGNC; VGNC:68597; NUMBL.
DR eggNOG; KOG3537; Eukaryota.
DR GeneTree; ENSGT00940000160957; -.
DR HOGENOM; CLU_031797_1_1_1; -.
DR InParanoid; M3W286; -.
DR OMA; PWMSRSA; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000004467; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0034332; P:adherens junction organization; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0021670; P:lateral ventricle development; IEA:Ensembl.
DR GO; GO:0021849; P:neuroblast division in subventricular zone; IEA:Ensembl.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0019538; P:protein metabolic process; IEA:Ensembl.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR010449; Numb_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF4; NUMB-LIKE PROTEIN; 1.
DR Pfam; PF06311; NumbF; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017607};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 159..284
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..61
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..642
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 71328 MW; D4C186B7BCF27566 CRC64;
MGGAGAGSRG RRGAPPPPER NPPGSGAGSL ACIPHHPPAP GPGPRQTALP PPPPPPPPQQ
QQRSGIRAQP GPREAGAPGP WMSRSAAASG GPKRPEQRLP PAPCGALGPP ETSRTEPEGA
GTMNKLRQSL RRRKPAYVPE ASRPHQWQAD EDAVRKGTCS FPVRYLGHVE VEESRGMHVC
EDAVKKLKAM GRKSVKSVLW VSADGLRVVD DKTKDLLVDQ TIEKVSFCAP DRNLDKAFSY
ICRDGTTRRW ICHCFLALKD SGERLSHAVG CAFAACLERK QRREKECGVT AAFDASRTSF
AREGSFRLSG GGRPAEREAP EKKKAEAAAA PSAAPGPAQP GHVSPTPATT SPGEKGEAGT
PVAAGTSAAA IPRRHAPLEQ LVRQGSFRGF PALSQKNSPF KRQLSLRLNE LPSTLQRRTD
FQVKGTVPEM EPPGASDSDG INALCTQISS SFASAGAPAP GPPPASAGTS AWGESSVPPA
AAFQPGHKRT PSEAERWLEE VSQVAKAQQQ QQQQQQQQAA SVPPVAPALQ PFPAPVGPFD
ATPAQVAVFL PPPHMQPPFV PAYPGLGYPP MPRVPVVGIT PSQMVANAFC SAAQLQPQPA
TLLGKAGAFP PPAMPTAPGG QVRPRPNGAP WPPEPAPAPA PELDPFEAQW AALEGKPAVE
KPSNPFSGDL QKTFEIEL
//
