ID M3W2T4_FELCA Unreviewed; 1069 AA.
AC M3W2T4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=PTPRF interacting protein alpha 1 {ECO:0000313|Ensembl:ENSFCAP00000004406.6};
GN Name=PPFIA1 {ECO:0000313|VGNC:VGNC:105824};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000004406.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000004406.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004406.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000004406.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004406.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000004406.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004406.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR EMBL; AANG04000779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W2T4; -.
DR STRING; 9685.ENSFCAP00000004406; -.
DR Ensembl; ENSFCAT00000004767.6; ENSFCAP00000004406.6; ENSFCAG00000004765.6.
DR VGNC; VGNC:105824; PPFIA1.
DR eggNOG; KOG0249; Eukaryota.
DR GeneTree; ENSGT01050000244900; -.
DR HOGENOM; CLU_006923_0_0_1; -.
DR InParanoid; M3W2T4; -.
DR OMA; ENEMANK; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000004765; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0048786; C:presynaptic active zone; IBA:GO_Central.
DR GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IBA:GO_Central.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF15; LIPRIN-ALPHA-1; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 2.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 734..800
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 856..913
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..124
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 260..413
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 641..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 120203 MW; 3B08AF2ADC374F94 CRC64;
MMCEVMPTIS EAEGPPGGSG THGSGSPSQP DADSHFEQLM VSMLEERDRL LDTLRETQET
LALTQGKLHE VGHERDSLQR QLNTALPQEC AALAAELHTC RELLVQREEE IANLKAERNN
TRLLLEHLEF LVSRHERALQ KTIIGRQAKT PAGVSSEAEV LKVLNSILEK DKTEAETVRE
QLRVALEGCS FVEEELGATR RVQLQTSSQD LIGGGFLFIH FSEVQSQMKE LLATLCTLVA
KLEEDLDISR KDLILSEAMN TILQRDVREA MAQKEDMQDR ITTLEKRCLR AQHEATSLHD
LKDNLENEIA KKDSLHRQTA DQNRQLQERL EVAERKLQRG NIEESLHQME AQLEEKNQEL
QRVRQREKLK EETNQHLSGT IDRLLSESDE RLKRHLKERM AAAEDKVGHE RQRLSAPVLT
EETLTLRTHV GSIPASRFRL AGSPTDASST SSSAVLRRHR KGRVARLRHE PSKVQTLNEQ
DWERAQQASV LANVAQAFES DVDVSDGEDD GDTLFSSAAL LSPSGQADAQ TLAMMLQEQL
DAINKEIRLI QEEKESAEQR AEEIESRVGS GSLDSPGRFR PAGSGAPHPA SPLAGPSPPH
SGRSTPRRGP HSPAREVDRL GVMTLVSICL FFLRRSTPHP SPRLRCQTSS SQRSLSLDRL
QQGALHKASH EDIRDATNHP GAPYTFESVH RELPLFACYI PTGTRDSSAL NSLVICRHEL
LEEARRQGLP FAQWDGPTVV VWLELWVGMP AWYVAACRAN VKSGAIMSAL SDTEIQREIG
ISNPLHRLKL RLAIQEIMSL TSPSAPPTSR TTTGNIWLTH EEMETLTATP QTEAEEGSWA
QTLAYGDMNH EWIGNEWLPS LGLAQYRSYF MECLVDARML DHLTKKDLRG QLKMVDSFHR
NSFQCGIMCL RRLNYDRKEL ERKREESQSE VKEVLVWRKD PVIRWVLSIG LKEDANNRVD
GGVHGTLMAL DGTFDVTALA LLVQIPTQNT QARAVLEWEF NNLLVMGTDR RFDEDDDKSF
RRAPSWRKQC RPKDICDLAA GSAETLPADF WVTSSLSSMQ PKKMQLDGT
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