ID M3W3Y5_FELCA Unreviewed; 417 AA.
AC M3W3Y5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Lipase H {ECO:0000313|Ensembl:ENSFCAP00000004976.5};
GN Name=LIPH {ECO:0000313|Ensembl:ENSFCAP00000004976.5,
GN ECO:0000313|VGNC:VGNC:63239};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000004976.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000004976.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004976.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000004976.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004976.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000004976.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000004976.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR EMBL; AANG04001816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W3Y5; -.
DR ESTHER; felca-a0a337s3d4; Phospholipase.
DR Ensembl; ENSFCAT00000005368.5; ENSFCAP00000004976.5; ENSFCAG00000005367.6.
DR VGNC; VGNC:63239; LIPH.
DR eggNOG; ENOG502QUQT; Eukaryota.
DR GeneTree; ENSGT00940000156285; -.
DR HOGENOM; CLU_027171_3_0_1; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000005367; Expressed in zone of skin and 7 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF12; LIPASE MEMBER H; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 2.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..417
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016465202"
FT DOMAIN 38..177
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
SQ SEQUENCE 417 AA; 47194 MW; 90E2ADDD75F4B969 CRC64;
MLRLSFFFGL ICLVKTDTDE TCPSFTKLSF HSAVVGTGLN VKLMLYTRKN LTCAQVINST
ILGNLNVTKK TTFIVHGFRP TGSPPVWMED LVQSLLSVED MNVIVVDWNR GATTVIYNHA
SSKTRKVAEV LKKFIDQVLI EGASLDNIYM IGVSLGAHIS GFVGKMYNGQ LGRITALGYK
EPLGNIDFYP NGGLDQPGCP KTILGGLQYF KCDHQRSVYL YLSSLRENCA ITAYPCDSYR
DYRNGKCVNC GMPQKESCPL LGYYADNWKE YLKQKEPPMT KAFFDTAEEK PFCIYHYFVD
IITWNKNIRR GSITIRLTDR AGNTTESKIN HEPATFQKYH QVSLLARFNQ DLDKVAAISL
VFSTGSTIGP KYKLRILRMK LRSLAHPERP QLCRYDLVLM ENTETVFQPI LCPKLQM
//
