ID M3W4R6_FELCA Unreviewed; 1146 AA.
AC M3W4R6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Rho GTPase activating protein 23 {ECO:0000313|Ensembl:ENSFCAP00000005401.5};
GN Name=ARHGAP23 {ECO:0000313|Ensembl:ENSFCAP00000005401.5,
GN ECO:0000313|VGNC:VGNC:59880};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005401.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005401.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005401.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005401.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005401.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005401.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005401.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W4R6; -.
DR Ensembl; ENSFCAT00000005818.6; ENSFCAP00000005401.5; ENSFCAG00000005816.6.
DR VGNC; VGNC:59880; ARHGAP23.
DR eggNOG; KOG4407; Eukaryota.
DR GeneTree; ENSGT00940000157982; -.
DR HOGENOM; CLU_001776_1_0_1; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000005816; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 71..156
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 689..810
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 907..1099
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 214..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..408
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 126244 MW; 3DD23F414D675062 CRC64;
MNGVAFCLVG IPPRPEPRPP QLPLGPRDGC SPGRPLPWQG PRTLLLCKSL QDGFGFTLRH
FIVYPPESAV HCSLKEEENG GRGGGPSPRH HRLEPMDTIF VKNVKDDGPA HRAGLRTGDR
LVKVNGESVI GKTYSQVIAL IQNSDDTLEL SIMPKDEDIL QLAYSQDAYL KGNEPYSGEA
RSIPEPPPIC YPRKTYAPPA RVSTWATMVP EPLSALPSDP RSPAAWSDPG PRVPSATRTH
PDNSSLGMSQ PRPSPGAFPR LPSEPRTPRA FPEPGSRVPP SRLECQQALS HWLSNQVPRR
AGERRCPAMP PRARSASQDR LEDVTAHRPW PCSTSQGALS QLGQEGWHRA RSDDYLSRAT
RSAEALGPGA LVSPRFERCG WASQRPSART PACPPRDLPA PQAPPPPGLQ GLDDIGYIGY
RSYSPSFQRR TGLLHALSFR DSPFGGLPTF NLAQSPASFP LEASEPPRVV RPEPSTRALE
PATEDRRDEV VLRQKPPTGR KVQLPSARQM NLGFGEESPE PESSGRVERL GRKVAPLATT
EDSLASIPFI DEPTSPSIDL QAKHVPASAV VSSAMNSAPV LGTSPSSPTF TFALGRHYSQ
DCSSLKAGRR SSYLLAITTE RSKSCDDGLN TFREEGRALR RLPNRVPSLR MLRSFFTDGS
LDSWGTSEDA DVPSKRHSTS DLSDATFSDI RREGWLYYKQ VLTKKGKKAG GGLRQWKRVY
AALRARSLLL SKERREPGPA AAAGAAAAVA GEDEAAPVCI GSCLVDISYS ETKRRHVFRL
TTADFCEYLF QAEDRDDMLG WIRAIRENSR AEGEDPGCAN QALISKKLND YRKVSHSSGP
KADSSPKVSR GLGGLKSEFL KQSTARGFRT QDQSAGSKDD SATTPKTPWG INIIKKNKKA
APRAFGVRLE ECQPAIENQR VPLIVAACCR IVEARGLEST GIYRVPGNNA VVSSLQEQLN
RGPGDINLQD ERWQDLNVIS SLLKSFFRKL PEPLFTDDKY NDFIEANRIE DSRERMKTLR
KLIRDLPGHY YETLKFLVGH LKTIADHSEK NKMEPRNLAL VFGPTLVRTS EDNMADMVTH
MPDRYKIVET LIQHSDWFFS DDEDKGERTP VDDKEPQSVP NIEYLLPNIG RTVPPGDPGS
ADLLEI
//
