ID M3W4Z0_FELCA Unreviewed; 642 AA.
AC M3W4Z0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Arylsulfatase L {ECO:0000313|Ensembl:ENSFCAP00000005502.4};
GN Name=ARSL {ECO:0000313|Ensembl:ENSFCAP00000005502.4,
GN ECO:0000313|VGNC:VGNC:108359};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005502.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005502.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005502.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005502.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005502.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005502.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005502.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; AANG04001271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W4Z0; -.
DR STRING; 9685.ENSFCAP00000005502; -.
DR PaxDb; 9685-ENSFCAP00000005502; -.
DR Ensembl; ENSFCAT00000005925.5; ENSFCAP00000005502.4; ENSFCAG00000005924.5.
DR VGNC; VGNC:108359; ARSL.
DR eggNOG; KOG3867; Eukaryota.
DR GeneTree; ENSGT00940000163319; -.
DR HOGENOM; CLU_006332_13_4_1; -.
DR InParanoid; M3W4Z0; -.
DR OMA; ITGQSCF; -.
DR Proteomes; UP000011712; Chromosome X.
DR Bgee; ENSFCAG00000005924; Expressed in eyeball of camera-type eye and 11 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0004065; F:arylsulfatase activity; IBA:GO_Central.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 1.10.287.550; Helix hairpin bin; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR PANTHER; PTHR42693:SF5; ARYLSULFATASE L; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR Pfam; PF14707; Sulfatase_C; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 91..476
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 71246 MW; F3292A69F72C3D2F CRC64;
MRAAGRPAEE AWALAAASGQ SRRTSRALCC TASRSLRSRR PGPDGAQPSR NYERKENMLR
LEHAWTWLAV TVGALLGVTP SASRDLSGSR PNILLLMADD FGIGDIGCYG NDTIRTPNID
RLARDGVMLT QHLAAASVCT PSRAAFLTGR YPLRSGMVSS NGYRVLQWTG VSGGLPTNET
TFAKILKDRG YATGLIGKWH LGLNCESSND HCHHPLNHGF DHFYGMPFSM MGDCVRWELS
EKRAGMERKL NVCFQIMAVA ALTLTAGKLT HLTSGSWTPV IWSTMAAIFL FTTSYFLGDL
IVHADCFLMR NHTITEQPMH FPRTTSLILK EVSSFIQRNK QTPFLLFVSF LHVHTPLITT
EKFRGKSVHG LYGDNTEEMD WMLGKILDTL DTEGLTNSTL VYFTSDHGGS LESRLRNNQY
GGSNGIYKGG KGMGGWEGGI RVPGIFRWPG VLPAGRVIHE PTSLMDVFPT VVQLGGGEVP
QDRVIDGRDM LPLLLGTAQH SDHEFLLHYC ENFLHAVRWH QRDGGRLWKV HYTTPVFHPH
GAGACYGRGV CPCFGDQVAH HDPPLLFDLS RDPSEAHALT PDTEPAFYRV MDTISRAVEE
HRRTLRPVPV QLDAPGNIWK PWLQPCCGPF PLCWCDRENG QA
//
