ID M3W539_FELCA Unreviewed; 4862 AA.
AC M3W539;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Baculoviral IAP repeat containing 6 {ECO:0000313|Ensembl:ENSFCAP00000005572.5};
GN Name=BIRC6 {ECO:0000313|Ensembl:ENSFCAP00000005572.5,
GN ECO:0000313|VGNC:VGNC:80031};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005572.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005572.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005572.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005572.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005572.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005572.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005572.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000005572; -.
DR PaxDb; 9685-ENSFCAP00000005572; -.
DR Ensembl; ENSFCAT00000005999.6; ENSFCAP00000005572.5; ENSFCAG00000005996.6.
DR VGNC; VGNC:80031; BIRC6.
DR eggNOG; KOG0895; Eukaryota.
DR eggNOG; KOG1101; Eukaryota.
DR GeneTree; ENSGT00940000156126; -.
DR HOGENOM; CLU_000111_1_0_1; -.
DR InParanoid; M3W539; -.
DR OMA; GPLDAQC; -.
DR Proteomes; UP000011712; Chromosome A3.
DR Bgee; ENSFCAG00000005996; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005815; C:microtubule organizing center; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0060711; P:labyrinthine layer development; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0060712; P:spongiotrophoblast layer development; IEA:Ensembl.
DR CDD; cd00022; BIR; 1.
DR CDD; cd00195; UBCc; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR022103; BIRC6.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR46116; (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME; 1.
DR PANTHER; PTHR46116:SF39; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6; 1.
DR Pfam; PF00653; BIR; 1.
DR Pfam; PF12356; BIRC6; 1.
DR Pfam; PF00179; UQ_con; 1.
DR SMART; SM00238; BIR; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 4578..4745
FT /note="UBC core"
FT /evidence="ECO:0000259|PROSITE:PS50127"
FT REGION 465..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2948..2976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3733..3753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3927..3954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4818..4862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1617..1661
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1054..1073
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4862 AA; 530293 MW; EB44D2FF02ECF4A0 CRC64;
MVTGGGAAPP GTVTEPLPSV IVLSAGRKMA AAAAAASGSG CSSAAGAGAA GVSEWLVLRD
GCMRCDAEGL HSLSYHPALN AILAVTSRGT IKVIDGTSGA TLQASALSAK PGGQVKCQYI
SAVDKVIFVD DYAVGCRKDL NGILLLDTAL QTPVSKQDDV VQLELPVTEA QQLLSACLEK
VDISSTEGYD LFITQLKDGL KNTSHETAAN HKVAKWATVT FHLPHHVLKS IASAIVNELK
KINQNVAALP VASSVMDRLS YLLPSARPEL GVGPGRSVDR SLMYSEANRR ETFTSWPHVG
YRWAQPDPMA QAGFYHQPAS SGDDRAMCFT CSVCLVCWEP TDEPWSEHER HSPNCPFVKG
EHTQNVPLSV TLATSPAQFP CTDGTDRISC FGSGSCPHFL AAATKRGKIC IWDVSKLMKV
HLKFEINAYD PAIVQQLILS GEPSSAVESR RPTLAWLEDS SSCSDIPKLE GDSDDLLEDS
DSEEHSRSDS VTGHTSQKEA MEVSLDITAL SILQQPEKLQ WEIVANVLED TVKDLEELGA
NPCLTNSKSE KTKEKHQEQH NIPFPCLLAG GLLTYKSPAT SPISSNSHRS LDGLSRTQGE
SISEQGSTDN ESCTNSELNS PLVRRTLPIL LLYSIKESDE KAGKIFSQMN NIMSKSLHDD
GFTVPQIIEM ELDSQEQLLL QDPPVTYIQQ FADAAANLTS PDSEKWNSVF PKPGTLVQCL
RLPKFAEEEN LCIDSITPCA DGIHLLVGLR TCPVESLSAI NQVEALNNLN KLNSALCNRR
KGELESNLAV VNGANISVIQ HESPADVQTP LIIQPEQRNV SGGYLILYKM NYATRIVTLE
EEPIKIQHIK DPQDTITSLI LLPPDILDNR EDDCEEPVEE MQLTSKNGIE REKKADISTL
GHLVITTQGG YVKILDLSNF EILAKVEPPK KEGTEEQDTF VSVIYCSGTD RLCACTKGGE
LHFLQIGGAC DDIDEADILV DGALSKGIEP SSEGSKPLSN PSSPGISGVD LLVDQPFTLD
ILTSLVELTR FETLTPRFSA TVPPCWVEVQ QEQQQRRHPQ HLHQQHHGDA AQHTRTWKLQ
TDSNSWDEHV FELVLPKACM VGHVDFKFVL NSNITNIPQI QVTLLKNKAP GLGKVNALNI
EVEQNGKPSL VDLNEEMQHM DVEESQCLRL CPFLEDHKED ILCGPVWLAS GLDLSGHAGM
LTLTSPKLVK GMAGGKYRSF LIHVKAVNER GTDEICNGGI RPVVRLPSLK HQSNKGYSLA
SLLAKVAAGK EKSSNVKNEN SSSARKSENL RGCDLLQEVS VTIRRFKKTS ISKERVQRCA
MLQFSEFHEK LLNTLCRKAD DGQITEHAQS LVLDTLCWLA GVHSNGPGSS KEGNESLLSK
TRKCLSDIVR VCFFEAGRSI AHKCARFLAL CISNGKCDPC QPGFGSVLLK ALLENMSFLP
AAATGGSVYW YFVLLNYVKD EDLAGCSTAC ASLLTAVSKQ LQDRLTPMEA LLQTRYGLYS
SPFDPVLFDL EMSGSSCKNV YNSSIGVQSD EIDLSDVLSG NGKVSSCTAA EGSFTSLTGL
LEVEPLHFTC VSTSDGTRIE RDDAMSSFGV TPAVGGLSSG TVGEASTALS SAAQVALQSL
SHAMASAEQQ LQVLQEKQQQ LLKLQQQKAK LEAKLHQTTA AAAAAASAAS AVGPVHNSVP
SNPVAAPGFF IHPSDVIPPT PKTTPLFMTP PLTPPNEAVS VVINAELAQL FPGSVIDPPT
VNLAAHNKNS NKSRMNPLGS GLALAISHAS HFLQPPPHQS IIIERMHSGA RRFVTLDFGR
PILLTDVLIP TCGDLASLSI DIWTLGEEVD GRRLVVATDI STHSLILHDL IPPPVCRFMK
ITVIGRYGST NARAKIPLGF YYGHTYILPW ESELKLMHDP LRGEGESANQ PEIDQHLAMM
VALQEDIQCR YNLACHRLET LLQSIDLPPL NSANNAQYFL RKPDKAVEED SRVFSAYQDC
IQLQLQLNLA HNAVQRLKVA LGTSRKVLSE TSDPKDLIQT SSTEQLRTII RYLLDTLLSL
LHSSNGHSVP AVLQSTFHAQ ACEELFKHLC ISGTPKIRLH TGLLLVQLCG GERWWGQFLS
NVLQELYNSE QLLIFPQDRV FMLLSCIGQR SLSNSGVLES LLNLLDNLLS PLQPQLPMHR
RTEGVLDIPM ISWVVMLVSR LLDYVATVED EAAAAKKPLN GNQWSFINNN LHTQSINRSS
KGSSSLDRLY SRKIRKQLVH HKQQLNLLKA KQKALVEQME KEKIQSNKGS SYKLLVEQAK
LKQATSKHFK DLIRLRRTAE WSRSNLDTEV TTTKESPEIE PLPFTLAHER CISVVQKLTL
FLLSMDFTCH ADLLLFVCKV LARIANATRP TIHLCEIVNE PQLERLLLLL VGTDFNRGDI
SWGGAWAQYS LTCMLQDILA GELLAPVAAE AMEEGAVSDD VAAAAGDSDD SLQQSSVQLL
ETIDEPLTHD ITGAPPLSSL EKDKEIDLEL LQDLMEVDID PLDIDLEKDP LAAKVFKPIS
STWYDYWGAD YGTYNYNPYI GGLGIPVAKP PASTEKNGSQ TVSVSVSQAL DARLEVGLEQ
QAELMLKMMS TLEADSILQA LTNTSPTLSQ SPTGTDDSLL GGLQAASQSS QLIIQLSSVP
MLNVCFNKLF SMLQVHHVQL ESLLQLWLTL SLNSSSSGNK ENGADIFLYN ANRIPVISLN
QASITSFLTV LAWYPNTLLR TWCLVLHSLT LMTNMQLNPG SSNAIGTQES TAHLLVSDPN
LIHVLVKFLS GTSPHGTNQH SPQVGPTATQ AMQEFLTRLQ VHLSSTCPQI FSEFLLKLIH
ILSTERGAFQ TGQGPLDAQV KLLEFTLEQN FEVVSVSTIS AVIESVTFLV HHYITCSDKV
MSRSGSDSSV GARACFGGLF ANLIRPGDAK AVCGEMTRDQ LMFDLLKLVN ILVQLPLSGN
REYSARVSVT TNTTDSVSDE EKVSGGKDGN GSSSSVQGSP AYVADLVLAN QQIMSQILSA
LGLCNSSAMA MIIGASGLHL TKHENFHGGL DAISVGDGLF TILTTLSKKA STVHMMLQPI
LTYMACGYMG RQGSLATCQL SEPLLWFILR VLDTSDALKA FHDMGGVQLI CNNMVTSTRA
IVNTARSMVS TIMKFLDSGP NKAVDSTLKT RILASEPDNA EGIHNFAPLG TITSSSPTAQ
PAEVLLQATP PHRRARSAAW SYIFLPEEAW CDLTIHLPAA VLLKEIHIQP HLASLATCPS
SVSVEVSADG VNMLPLSTPV VTSGLTYIKI QLVKAEVASA VCLRLHRPRD ASTLGLSQIK
LLGLTAFGTT SSATVNNPFL PSEDQVSKTS IGWLRLLHHC LTHISDLEGM MASAAAPTAN
LLQTCAALLM SPYCGMHSPN IEVVLVKIGL QSTRIGLKLI DILLRNCAAS GSDPTDLNSP
LLFGRLNGLS SDSTIDILYQ LGTTQDPGTK DRIQALLKWV SDSARVAAMR RSGRMSYMCP
NSSTVEYGLL MPSPSHLHCV AAILWHSYEL LVEYDLPALL DRDLFELLFN WSMSLPCNMV
LKKAVDSLLC SMCHIHPNYF SLLMGWMGIT PPPVQCHHRL SMTDDSKKQD LTSSLTDDSK
NAQAPLALTE SHLATLASSS QSPEAIKQLL DSGLPSLLVR SLASFCFSHI SYSESIAQSI
DTSQDKLRRH HVAQQCNKMP ITADLVAPIL RFLTEVGSSH VMKDWLGGSE VNPLWTALLF
LLCHSGSASG GHNLGAQQQT SARPASLSSA APTGLTTQQR TAIENATVAF FLQCISCHPH
NQKLMAQVLC ELFQTSPQRG NLPTSGNISG FIRRLFLQLM LEDEKVTMFL QSPCPLYKGR
INATSHVIQH PMYGAGHKFR TLHLPVSTTL SEVLDRVSDT PSITAKLISE QKDDKEKKNH
EEKEKVKAEN GFQDNYSVVV ASGLKSQSKR AVSATPPRPP SRRGRTIPDK IGSASSGAEA
ANKIITVPVF HLFHKLLAGQ PLPAEMTLAQ LLTLLYDRKL PQGYRSIDLT VKLGSRVITD
PSLSKTDSFK RLHPEKDHGD LLGSCPEDEA LTPSDECMDG VLDESLLETC PIQSPLQVFA
GMGGLALIAE RLPMLYPEVI QQVSAPVVTS TTQEKPKDSD QFEWVTIEQS GELVYEAPET
IAAEPPPIKS AVQTMSPIPA HSLAAFGLFL RLPGYAEVLL KERKHAQCLL RLVLGVTDDG
EGSHILQSPS ANVLPTLPFH VLRSLFSTTP LTTDDGVLLR RMALEIGALH LILVCLSALS
HHAPRVPNSS LNQAEPQVSS SHNPTSTEEQ QLYWAKGTGF GTGSTASGWD VEQALTKQRL
EEEHVTCLLQ VLASYINPMS GAVNGEAQSS HESRVQNSNA LPSVLLELLS QSCLIPAMSS
YLRNDSVLDM ARHVPLYRAL LELLRAIASC TSMVPLLLPL STENGEEEEE QSECQTSVGT
LLAKMKTCVD TYTNRLRSKR ENVKTGVKPD ASDQEPEGLT LLVPDIQKTA EIVHAATTSL
RQANQEKKLG ECSKKVAMKP KPLSVLKSLE EKYVAVMKKL QFDTFEMVSE DEDGKLGFKV
NYHYMSQVKN ANDANSAARA RRLAQEAVTL STSLPLSSSS SVFVRCDEER LDIMKVLITG
PADTPYANGC FEFDVYFPQD YPSSPPLVNL ETTGGHSVRF NPNLYNDGKV CLSILNTWHG
RPEEKWNPQT SSFLQVLVSV QSLILVAEPY FNEPGYERSR GTPSGTQSSR EYDGNIRQAT
VKWAMLEQIR NPSPCFKEVI HKHFYLKRVE IMAQCEEWIA DIQQYSSDKR VGRTMSHHAA
ALKRHTAQLR EELLKLPCPE GLDPDADDAS EMCSATAGAE GTLTHDQVKP SSSKDLPSDF
KL
//