ID M3W5D7_FELCA Unreviewed; 1135 AA.
AC M3W5D7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=DExH-box helicase 34 {ECO:0000313|Ensembl:ENSFCAP00000005711.5};
GN Name=DHX34 {ECO:0000313|Ensembl:ENSFCAP00000005711.5,
GN ECO:0000313|VGNC:VGNC:61479};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005711.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005711.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005711.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005711.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005711.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005711.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005711.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W5D7; -.
DR STRING; 9685.ENSFCAP00000005711; -.
DR PaxDb; 9685-ENSFCAP00000005711; -.
DR Ensembl; ENSFCAT00000006146.5; ENSFCAP00000005711.5; ENSFCAG00000006144.5.
DR VGNC; VGNC:61479; DHX34.
DR eggNOG; KOG0922; Eukaryota.
DR GeneTree; ENSGT00940000158721; -.
DR HOGENOM; CLU_001832_5_2_1; -.
DR InParanoid; M3W5D7; -.
DR OMA; CIFANSP; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000006144; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:2000623; P:negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:Ensembl.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl.
DR CDD; cd17979; DEXHc_DHX34; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF148; ATP-DEPENDENT RNA HELICASE DHX34-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 171..331
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 367..535
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1135 AA; 127492 MW; 46A36D0EBF2B39FB CRC64;
MPPPRTKEGG DDRGRHWDPS EEDAPEKWDW NCPETRRLFE DAFFRDEDYI PQGSEERKKF
WTFFERLQRF QNLKSTRKGD KDPGRPKHSI PALADLPRAY DPRYRINLSV RGPDARGSRG
LDRQPPEKVS EFRRALLHYL DFGQKQAFGR LARLQRERAA LPIAQYGTRI LQTLKEHQVV
VVAGDTGCGK STQVPQYLLA AGFSHVACTQ PRRIACISLA KRVSFESLSQ YGSRVGYQIR
FESTRTAATK IVFLTVGLLL RQIQREPRLP QYQVLIVDEV HERHLHNDFL LGVLRRLLPE
RPDLKVILMS ATINISLFSS YFGGAPVVQV PGRLFPITVV YQPQEAEPPA SKSEKLDPRP
FLRVLEAIDN KYPPEERGDL LVFLSGMAEI SAVLEAAQAY ASRTQRWVVL PLHSALSVAD
QDKVFDVAPP GVRKCILSTN IAETSVTIDG IRFVVDSGKV KEMGYDPQAK LQRLQEFWIS
QASAEQRKGR AGRTGPGVCF RLYAESDYDA FAPYPVPEIR RVALDALVLQ MKSMCVGDPR
TFPFIEPPPP ASLETAILYL RDQGALDSSE ALTPIGSLLA QLPVDVVIGK MLILGSMFHL
AEPVLTIAAA LSVQSPFTRS AQSNPEGAAA RRPLDSDHGD PFTLFNVFNT WVQVKSERSR
SSRKWCRHRC IEEHRLYEMA NVRRQFKELL EDHGLLARAQ APKPGDSYSR LRQRRERRAL
YQLKRRHEEG GAHRRKVLRL QEDPGGCSSE EDPGAGDSVD IQDVKFKLRH SLDQLQAATT
SAQDLTRDQV ALLKLVLGRG LYPQLAVPDP FNSSRKDSDQ IFHTQSKQGT VPHPTSVFAS
SPEVLHAQEQ EAGGGEGSRD DKDKLSSRHQ LLTFVSLLET NKAYLVNCVR IPALQSLLLF
SRSVDTNGDC SRLVADGWLE LQLADSESAV RLLAASVRLR ARWESALDRQ LARQAQQRRE
EEEEDPVARK EVADLSRELL KFTASKVPYS LRRLTGLEVQ NLYVGPQTIT AMPSLPGLFG
SSALSPHPTK GGYAVTDFLT YNCLTSDTDL YSDCLRTFWT CPHCGLHVPL TPLERIAHEN
TCPEAPQDGP PGAEEAAPEP LQKASVLQKP YHCAVCQKDF LFTPTEVLRH RRQHV
//