ID M3W5V5_FELCA Unreviewed; 1075 AA.
AC M3W5V5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Dishevelled associated activator of morphosis 2 {ECO:0000313|Ensembl:ENSFCAP00000005962.5};
GN Name=DAAM2 {ECO:0000313|Ensembl:ENSFCAP00000005962.5,
GN ECO:0000313|VGNC:VGNC:61327};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000005962.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000005962.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005962.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000005962.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005962.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000005962.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000005962.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019686117.1; XM_019830558.1.
DR RefSeq; XP_019686118.1; XM_019830559.1.
DR RefSeq; XP_019686119.1; XM_019830560.1.
DR RefSeq; XP_019686120.1; XM_019830561.1.
DR RefSeq; XP_019686121.1; XM_019830562.1.
DR AlphaFoldDB; M3W5V5; -.
DR STRING; 9685.ENSFCAP00000005962; -.
DR PaxDb; 9685-ENSFCAP00000005962; -.
DR Ensembl; ENSFCAT00000006417.6; ENSFCAP00000005962.5; ENSFCAG00000006415.6.
DR GeneID; 101086145; -.
DR CTD; 23500; -.
DR VGNC; VGNC:61327; DAAM2.
DR eggNOG; KOG1922; Eukaryota.
DR GeneTree; ENSGT00940000157801; -.
DR HOGENOM; CLU_002356_1_0_1; -.
DR InParanoid; M3W5V5; -.
DR OMA; PCFGMGL; -.
DR OrthoDB; 5485896at2759; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Bgee; ENSFCAG00000006415; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0021516; P:dorsal spinal cord development; IEA:Ensembl.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IBA:GO_Central.
DR GO; GO:0090521; P:podocyte cell migration; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:2000050; P:regulation of non-canonical Wnt signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45725:SF7; DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2; 1.
DR PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 40..416
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 595..1002
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1024..1055
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 514..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..510
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 696..723
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 973..1009
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1075 AA; 124237 MW; 8FE89972DEBD5CB3 CRC64;
MAPRKRSRHG LGFLCCFGGS GLPEINLRDN HPLQYMEFSS PIPNPEELNV RFAELVDELD
LTDKNREAVF ALPPEKKWQI YCSKKKEQED PNKLATSWPD YYIDRINSMA AMQSLYAFDE
EETEMRNQVV EDLKTALRTQ PMRFVTRFIE LEGLTCLLNF LRSMDHATCE SRIHTSLIGC
IKALMNNSQG RAHVLAQPEA ISTIAQSLRT ENSKTKVAVL EILGAVCLVP GGHKKVLQAM
LHYQVYAAER TRFQTLLNEL DRSLGRYRDE VNLKTAIMSF INAVLNAGAG EDNLEFRLHL
RYEFLMLGIQ PVIDKLRQHE NAILDKHLDF FEMVRNEDDL ELARRFDMVH IDTKSASQMF
ELIHKKLKHT EAYPCLLSVL HHCLQMPYKR NGGYFQQWQL LDRILQQIVL QDERGVDPDL
APLENFNVKN IVNMLINENE VKQWRDQAEK FRKEHMELVS RLERKERECE TKTLEKEEMM
RTLNKMKDKL ARESQELRQA RGQVAELVAQ LSEISTGPVS SPPPPGGPLT LSSSMTTNDL
PPPPPPLPFA CCPPPPPPPL PPGGPPTPPG APPCFSMGLP LPPDPCPSSD IPLRKKCVPQ
PSHPLKSFNW VKLNEERVPG TVWNEVDDMR VFRILDLEDF EKMFSAYQRH QELITNPQQK
ELGSTEDIYL ASRKVKELSV IDGRRAQNCI ILLSKLKLSN EEIRQAILKM DEQEDLAKDM
LEQLLKFIPE KSDIDLLEEH KHEIERMARA DRFLYEMSRI DHYQQRLQAL FFKKKFQERL
AEAKPKVEAI LLASRELIRS KRLMRMLEVV LAIGNFMNKG QRGGAYGFRV ASLNKIADTK
SSIDRNISLL HYLIMILEKH FPDILNMPSE LQHLPEAAKV NLAELEKEVG NLRRGLRAVE
VELEYQKRQA REPNDKFVPV MSDFITVSSF SFSELEDQLN EARDKFSKAL MHFGEQDSKM
QPDEFFGIFD TFLQAFSEAR QDLETMRRRK EEEERRARME AMLKEQRERE RWQRQRKVHA
GSTLEEGGEF DDLVSALRSG EVFDKDLCKL KRSRKRSGSQ APEVTRERAI SRLNY
//
