ID M3W6G2_FELCA Unreviewed; 461 AA.
AC M3W6G2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Hepatic and glial cell adhesion molecule {ECO:0000313|Ensembl:ENSFCAP00000006277.6};
GN Name=HEPACAM {ECO:0000313|Ensembl:ENSFCAP00000006277.6,
GN ECO:0000313|VGNC:VGNC:62796};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000006277.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000006277.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006277.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000006277.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006277.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000006277.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006277.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W6G2; -.
DR Ensembl; ENSFCAT00000006756.6; ENSFCAP00000006277.6; ENSFCAG00000006755.6.
DR VGNC; VGNC:62796; HEPACAM.
DR eggNOG; ENOG502QPJB; Eukaryota.
DR GeneTree; ENSGT01100000263551; -.
DR HOGENOM; CLU_058570_1_0_1; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000006755; Expressed in prefrontal cortex and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44888; HEPACAM FAMILY MEMBER 2-RELATED; 1.
DR PANTHER; PTHR44888:SF2; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..225
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 264..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 51271 MW; 15E84F61D71BAB96 CRC64;
MPLVVGLSTS RQRTDGTHQI RTHIGDYILS RYPILNWGCS ALKLENARSE REERTSPAIH
RALCIQREVG RVVFGQRNSE WYKGTCPEWR NHANCLHQSW RTPPKMKRER GALSRAFSAL
SLTPFVYLLL IQTVPISRPQ VLVASTTVLE LSEAFTLNCS HENGTKPSYT WLKDGKPLLN
DSRMLLSPDH KVLTITRVLM EDDDLYSCVV ENPISQGRSL PIKITVYRRS SLYIILSTGG
IFLLVTLVTV CACWKPSKKS GKKRKLEKQN SLEYMDQNDD RLKPEGELPA THSPIPSPLR
SVGCWEKAEL GHKEASSAGP LPPPTARRLQ SRERCGQADT LPRSGEQERK NPMALYILKD
KDSPEPEENP APEPRSATEP GPPGYSVSPA VPGRSPGLPI RSARRYPRSP ARSPATGRTH
TSPPRAPGSP GRSRSASRTL RTAGVHLIRE QDEASPVEIS A
//
