ID M3W8C4_FELCA Unreviewed; 278 AA.
AC M3W8C4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Ethylmalonyl-CoA decarboxylase {ECO:0000256|ARBA:ARBA00039903};
DE EC=4.1.1.94 {ECO:0000256|ARBA:ARBA00038883};
DE AltName: Full=Enoyl-CoA hydratase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042182};
DE AltName: Full=Methylmalonyl-CoA decarboxylase {ECO:0000256|ARBA:ARBA00042052};
GN Name=ECHDC1 {ECO:0000313|Ensembl:ENSFCAP00000007202.5,
GN ECO:0000313|VGNC:VGNC:97409};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000007202.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000007202.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007202.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000007202.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007202.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000007202.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007202.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2;
CC Xref=Rhea:RHEA:59540, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57371, ChEBI:CHEBI:85316; EC=4.1.1.94;
CC Evidence={ECO:0000256|ARBA:ARBA00036541};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59541;
CC Evidence={ECO:0000256|ARBA:ARBA00036541};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2;
CC Xref=Rhea:RHEA:32131, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57371, ChEBI:CHEBI:60909; EC=4.1.1.94;
CC Evidence={ECO:0000256|ARBA:ARBA00036343};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:32132;
CC Evidence={ECO:0000256|ARBA:ARBA00036343};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA;
CC Xref=Rhea:RHEA:61340, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57327, ChEBI:CHEBI:57392; EC=4.1.1.94;
CC Evidence={ECO:0000256|ARBA:ARBA00036425};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61341;
CC Evidence={ECO:0000256|ARBA:ARBA00036425};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU003707}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04000169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W8C4; -.
DR STRING; 9685.ENSFCAP00000007202; -.
DR PaxDb; 9685-ENSFCAP00000007202; -.
DR Ensembl; ENSFCAT00000007780.6; ENSFCAP00000007202.5; ENSFCAG00000007780.6.
DR VGNC; VGNC:97409; ECHDC1.
DR eggNOG; KOG1680; Eukaryota.
DR GeneTree; ENSGT00880000138038; -.
DR HOGENOM; CLU_009834_7_6_1; -.
DR InParanoid; M3W8C4; -.
DR OMA; CLSGEMM; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Bgee; ENSFCAG00000007780; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016831; F:carboxy-lyase activity; IEA:Ensembl.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR PANTHER; PTHR11941; ENOYL-COA HYDRATASE-RELATED; 1.
DR PANTHER; PTHR11941:SF27; ETHYLMALONYL-COA DECARBOXYLASE; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
SQ SEQUENCE 278 AA; 30406 MW; C7E4363CC2E08463 CRC64;
MELKQEMARS LLKTSSLSVR TKLLHQTGLS LYNTSHGFHE EEVKKKLEQF PGGSVDLQKE
DSGIGILTLN NPSKMNAFSG VMFLQLLEKV IELENWTEGK GLIVRGAKNT FSSGSDLNAV
KALGTPEDGM TLCMFMQNTL TRFMRLPLIS VALVQGRALG GGAEFTTACD FRLMTPESEI
RFVHKEMGII PSWGGATRLA EIIGSRQALK VLSGALKLDS KKALDIGMVD EVLQSSGETE
CLEEAQEWLK QFIKGPPEVI RALKKSVASA MLSPLSCK
//
