ID M3W8Y1_FELCA Unreviewed; 1708 AA.
AC M3W8Y1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=RPTOR independent companion of MTOR complex 2 {ECO:0000313|Ensembl:ENSFCAP00000007491.6};
GN Name=RICTOR {ECO:0000313|Ensembl:ENSFCAP00000007491.6,
GN ECO:0000313|VGNC:VGNC:64626};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000007491.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000007491.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007491.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000007491.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007491.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000007491.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007491.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
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DR EMBL; AANG04003171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9685-ENSFCAP00000007491; -.
DR Ensembl; ENSFCAT00000008085.6; ENSFCAP00000007491.6; ENSFCAG00000008083.6.
DR VGNC; VGNC:64626; RICTOR.
DR eggNOG; KOG3694; Eukaryota.
DR GeneTree; ENSGT00390000002096; -.
DR HOGENOM; CLU_001013_2_0_1; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000008083; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029259; RICTOR_phospho.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14665; RICTOR_phospho; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01309; RICTOR_phospho; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 57..439
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 523..742
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 920..992
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 1022..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1708 AA; 191892 MW; 36B516079DF809C2 CRC64;
MAAIGRGRSL KNLRIRGRND SGEENVPLDL TREPSDNLRE ILQNVAKLQG VSNMRKLGHL
NNFTKLLCDI GHSEEKLGFN YEDIIICLRL ALLNEAKEVR AAGLRALRYL IQDSSILQKV
LKLKVDYLIA RCIDIQQSNE VERTQALRLV RKMITVNASL FPSSVANSLI AVGNDGLQER
DRMVRACIAI ICELALQNPE VVALRGGLNT ILKNVIDCQL SRINEALITT ILHLLNHPKT
RQYVRADVEL ERILAPYTDF HYRHSPDTAE GQLKEDREAR FLASKMGIIA TFRSWAGIIN
LCKPGNSGIQ SLIGVLCIPN MEIRRGLLEV LYDIFRLPLP VVTEEFIEAL LSVDPGRFQD
SWRLSDGFVA AEAKTILPHR ARSRPDLMDN YLALILSAFI RNGLLEGLVE VITNSDDHIS
VRATILLGEL LHMANTILPH SHSHHLHCLP TLMNMAASFD IPKEKRLRAS AALNCLKRFH
EMKKRGPKPY SLHLDHIIQK AIATHQKRDQ YLRVQKDIFV LKDTEEALLM NLRDSQVLQH
KENLEWNWNL IGTILKWPNV NLRNYKDEQL HRFVRRLLYF YKPSSKLYAN LDLDFAKSKQ
LTVVGCQFTE FLLESEEDGQ GYLEDLVKDI VQWLNASSGM KPERSLQNNG LLTTLSQHYF
LFIGTLSCHP HGVKMLEKCS VFQCLLNLCS LKNQDHLLKL TVSSLDYSRD GLARVILSKI
LTAATDACRL YATKHLRVLL RANVEFFNNW GIELLVTQLH DKNKTISSEA LDILDEACED
KANLHALIQM KPALSHLGDK GLLLLLRFLS IPKGFSYLNE RGYVAKQLEK WHKEYNSKYV
DLIEEQLNEA LTTYRKPVDG DNYVRRSNQR LQRPHVYLPV HLYGQLVHHK TGCHLLEVQN
IITELCHNVR TPDLDKWEEI KKLKASLWAL GNIGSSNWGL NLLQEENVIP DILKLAKQCE
VLSVRGTCVY VLGLIAKTKQ GCDILKCHNW DSVRHSRKHL WPVVPDDVEQ LCNELSSIPS
TLSLNSESTS SRHNSESESA PSSMFIMEDD RFGSSSTSTF FLDISEDTEP AFYDRPGPIK
DKNSFPFFAS SKLVKNRILN SLTLPNKKHR SSSDPKGGKL SSENKTNNRR IRTLTEPSVD
FNHSDDFTPM STVQKTLQLE TSFVGNKHIE DAGSTPSIGE NDLKFTKSLG TENHRENTSR
ERLVVESSTS SHMKIRSQSF NTDTTTSGIS SMSSSPSRET VGVDTTTVDT DCGSMSTVVS
TKTVKTSHYL TPQSNHLSLS KSNSVSLVPP GSSHTLPRRA QSLKAPSIAT IKSLADCNFS
YTSSRDAFGY ATLKRLQQQR MHPSLSHSEA LASPAKDVLF TDTITMKANS FESRLTPSRF
MKALSYASLD KEDLLSPINQ NTLQRSSSVR SMVSSATYGS SDDYIGLALP VDINDIFQVK
DIPYFQTKNI PPHDDRGARV FAHDAGGLPS GTGGLVKNSF HLLRQQMSLT EIMNSIHSDA
SLFLESTEDT GLQEHTDDNC LYCVCIEILG FQPSNQLSAI CSHSDLQDIP YSDWCEQTIH
NPLEVVPSKF SGISGCSDGV SQEGSASSTK STELLLGVKT IPDDTPMCRI LLRKEVLRLV
INLSSSVSTK CHETGLLTIK EKYPQTFDDI CLYSEVSHLL SHCTFRLPCR RFIQELFQDV
QFLQMHEEAE AVLAAPPKPP AVDTAAES
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