ID M3W918_FELCA Unreviewed; 769 AA.
AC M3W918;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Semaphorin 7A {ECO:0000313|Ensembl:ENSFCAP00000007543.5};
GN Name=SEMA7A {ECO:0000313|Ensembl:ENSFCAP00000007543.5,
GN ECO:0000313|VGNC:VGNC:80850};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000007543.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000007543.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007543.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000007543.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007543.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000007543.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007543.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AANG04001761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W918; -.
DR STRING; 9685.ENSFCAP00000007543; -.
DR PaxDb; 9685-ENSFCAP00000007543; -.
DR Ensembl; ENSFCAT00000008145.6; ENSFCAP00000007543.5; ENSFCAG00000008142.6.
DR VGNC; VGNC:80850; SEMA7A.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000158358; -.
DR HOGENOM; CLU_009051_11_1_1; -.
DR InParanoid; M3W918; -.
DR OMA; GYHMGLP; -.
DR Proteomes; UP000011712; Chromosome B3.
DR Bgee; ENSFCAG00000008142; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:0021988; P:olfactory lobe development; IEA:Ensembl.
DR GO; GO:0045773; P:positive regulation of axon extension; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR CDD; cd11243; Sema_7A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042824; Sema7A_sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF80; SEMAPHORIN-7A; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 156..593
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 647..722
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 40..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 769 AA; 85580 MW; BEE71F29201ED8D7 CRC64;
MGYGGVDFRP REGTGPATDQ RSPRLSCPWR SGFSPWSCPG EGGEGSLAAG TAPPLGSREA
RKAAGWGSGE GGWGQEFDSA SLHWEQPAVG RWLSLGCSPL SLPGCGMTPP PPGCASLGAP
RARVPGRLAR SWLLLQLLLL LWTAAATQGH QRSGPRISAV WKGRAGQDWV DFGLAEPHTV
LFHEPGSSSV WVGGRGKVYF FDFPEGKNAS MRTVNIGSTK GSCLDKRDCE NYITLLERKG
EGLLICGTNA RRPSCWSLVN GTVESLGEKR GYAPFSPDEN SLVLFDGDEV YSTIRKQEFN
GKIPRFRRIQ GEIELYTSDT VMQNPQFIKA TIVHQDQAYD DKIYYFFRED NPDKNPEAPL
NVSRVAQLCR GDQGGESSLS VSKWNTFLKA MLVCSDVATN KNFNRLQDVF LLPDPNGQWR
DTRVYGVFSN PWNYSAVCVY SLGDIDKVFR TSSLKGYHSS LPNPRPGKCL PDRQPIPTET
FQVADSHPEV AQRVEPMGPL KTPLFHSKYH YQKVVVHRMQ ASRGETFHVL YLTTDRGTIH
KVVESEERER SLAFNIMEIQ PFHHPAAIQA MSLDAERRKL YVSSQWEVSQ VPLDLCEVYG
GGCHGCLMAR DPYCGWDQGR CVSIYSSQGP VLQSINPAEP HKECPNPKPD RAPLQKVSLA
RNSRYYLSCP MESRHATYSW RHEENVEQSC EPGHQSPNCI LFIENLTARQ YGHYHCEAQE
GSYLREAQHW ELLPDDGAMA EHLLGRARAL AASLWLGVLP TLTLGLLVH
//
