ID M3WAZ3_FELCA Unreviewed; 271 AA.
AC M3WAZ3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=IgG receptor FcRn large subunit p51 {ECO:0000256|ARBA:ARBA00040486};
DE AltName: Full=IgG Fc fragment receptor transporter alpha chain {ECO:0000256|ARBA:ARBA00041407};
DE AltName: Full=Neonatal Fc receptor {ECO:0000256|ARBA:ARBA00041280};
GN Name=FCGRT {ECO:0000313|Ensembl:ENSFCAP00000008525.5,
GN ECO:0000313|VGNC:VGNC:62209};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000008525.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000008525.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008525.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000008525.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008525.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000008525.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008525.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR EMBL; AANG04000747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WAZ3; -.
DR Ensembl; ENSFCAT00000009201.5; ENSFCAP00000008525.5; ENSFCAG00000009199.6.
DR VGNC; VGNC:62209; FCGRT.
DR eggNOG; ENOG502RTZ5; Eukaryota.
DR GeneTree; ENSGT01100000263475; -.
DR HOGENOM; CLU_047501_7_0_1; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000009199; Expressed in uterus and 10 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR CDD; cd21011; IgC1_MHC-like_FcRn; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR PANTHER; PTHR16675:SF3; IGG RECEPTOR FCRN LARGE SUBUNIT P51; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..271
FT /note="IgG receptor FcRn large subunit p51"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016383097"
FT TRANSMEM 207..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..196
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 271 AA; 29297 MW; DA9C04F5FEC64B88 CRC64;
MGVPRPQPWG LGFLLFLLPT LRAESHLSLL YHLTAVSSPA PGTPAFWVSG WLGPQQYLSY
NNLRAQAEPC GAWVWENQVS WYWEKETTDL RNKQELFLEA LKVLGEGEPP SMRLKARPGS
PGFSVLTCSA FSFYPPELQL RFLRNGLAAG SGEGDFGPNG DGSFHAWSSL TVKSGDEHHY
RCLVQHAGLP QPLTVELESP AKSSMPVVGI VIGLLLLTAA AAGGALLWRR MRNGLPAPWI
SLRGDDVGAL LPTPGLPKDA DSDINAFSAA A
//
