ID M3WCY7_FELCA Unreviewed; 1301 AA.
AC M3WCY7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=NPC1 like intracellular cholesterol transporter 1 {ECO:0000313|Ensembl:ENSFCAP00000009523.6};
GN Name=NPC1L1 {ECO:0000313|VGNC:VGNC:68529};
GN Synonyms=DDX56 {ECO:0000313|Ensembl:ENSFCAP00000009523.6};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000009523.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000009523.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009523.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000009523.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009523.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000009523.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009523.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AANG04002037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019680746.1; XM_019825187.1.
DR Ensembl; ENSFCAT00000010261.6; ENSFCAP00000009523.6; ENSFCAG00000010256.6.
DR GeneID; 101099108; -.
DR CTD; 29881; -.
DR VGNC; VGNC:68529; NPC1L1.
DR eggNOG; KOG1933; Eukaryota.
DR GeneTree; ENSGT00940000159904; -.
DR HOGENOM; CLU_002359_0_0_1; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000010256; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1301
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023928740"
FT TRANSMEM 282..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1084..1104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1110..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1177..1201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1213..1236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 633..798
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1301 AA; 141425 MW; 70CCF9603C953F96 CRC64;
MAEAGLRGWL LWALLLHSAR AELYTPIHRS GYCAFYDECG KNPELSGGLA PLANVSCLSN
TPARLLAGEH LALLRRICPR LYAGPDTTYA CCSAKQLVSL EASLAVTKAL LARCPACTDN
FVSLHCHNTC SPNQSLFVNV TRVARRGDGR PPAVVAYEAF YQSSFARRTY DSCSRVRVPA
AATLAVGTMC GVYGSALCNA QRWLNFQGDT GNGLAPLDIT FYLLEPGQTP GSGVQLLNGE
VAPCNESQAD GAAACSCQDC AASCPAIARP QALDATFYMG RMAGGLALII TLCSAFAVLT
AFLVGPRLAS RWGKGKMRDP TVGTSLSDKL SLSTHSLLSR CFQGWGTWVA SWPLSILLVS
IAVVVAFSGG LAFMELTTDP VELWSAPSSQ ARREKEFHDQ HFGPFLRTNQ VILTAPTRPG
SSYNSLLLGP KNFSGVLAPD VLLEVLELQE TLRHLQVWSP EEQRNVSLQD VCFAPLNPHN
TSLSDCCVNS LLQYFQNNRT RLLLTANQTL TGQTSQVDWR DHFLYCANAP LTFKDGTALA
LSCMADYGGP VFPFLAVGGY RGKDYSEAEA LIMTFSLNNY APRDSRLAQA KLWEGAFLET
MRAFQQRTAG RFQVTFMAER SLEDEINRTT AQDLPVFGVS YIVIFLYISL ALGSYSSWRR
VAVDAKATLG LGGVAVVLGA VTAAMGFFSY LGVPSSLVIL QVVPFLVLAV GADNIFILVL
EYQRLPRRPG ERREDHIGRA LGRVAPSMLL CSLSEAICFF LGALTPMPAV RTFALTSGLA
VILDFLLQVS AFVALLSLDS RRQEASRMDV CCCAGARELP PPGQSEGLLL RFFRKVYVPL
LLHRVTRVVV DSYLLDYFLF LNRYFEVGAP VYFVTTGGYN FSSEAGMNAI CSSAGCDSFS
LTQKIQFATE FPDESYLAIP ASSWVDDFID WLTPSSCCRL YAFGANKDKF CPSTVNSLAC
LKSCVNFTLG PVRPSVDQFH KYLPWFLEDP PNIKCPKGGL AAYSTSVDLG PGNQVLASRF
MAYHKPLRNS QDYTEALRAA RALAANITAH LRQVPGTDPA FEVFPYTITN VFYEQYLTVV
PEGLFMLAMC LLPTFAVCCL LLGMDLRSGL LNLFSIIMIL VDTVGFMALW GISYNAVSLI
NLVTAVGISV EFVSHITRAF AISTRLTRLE RAKEATIFMG SAVFAGVAMT NLPGILVLGL
AKAQLIQIFF FRLNLLITLL GLLHGLVFLP VVLSFVGPDV NVALVLEQKM EEAARARVAS
CPTHQAPTST ASSTYINHGF EHPAKSMGGA VGSLSRGGQE F
//
