ID M3WD28_FELCA Unreviewed; 1137 AA.
AC M3WD28;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=AP-4 complex subunit epsilon {ECO:0000256|PIRNR:PIRNR037097};
GN Name=AP4E1 {ECO:0000313|Ensembl:ENSFCAP00000009576.5,
GN ECO:0000313|VGNC:VGNC:81042};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000009576.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000009576.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009576.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000009576.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009576.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000009576.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009576.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor
CC protein complexes are vesicle coat components involved both in vesicle
CC formation and cargo selection. They control the vesicular transport of
CC proteins in different trafficking pathways. AP-4 forms a non clathrin-
CC associated coat on vesicles departing the trans-Golgi network (TGN) and
CC may be involved in the targeting of proteins from the trans-Golgi
CC network (TGN) to the endosomal-lysosomal system.
CC {ECO:0000256|PIRNR:PIRNR037097}.
CC -!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer composed
CC of two large adaptins, a medium adaptin and a small adaptin.
CC {ECO:0000256|PIRNR:PIRNR037097}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|PIRNR:PIRNR037097}.
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DR EMBL; AANG04001761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WD28; -.
DR STRING; 9685.ENSFCAP00000009576; -.
DR PaxDb; 9685-ENSFCAP00000009576; -.
DR Ensembl; ENSFCAT00000010317.5; ENSFCAP00000009576.5; ENSFCAG00000010314.5.
DR VGNC; VGNC:81042; AP4E1.
DR eggNOG; KOG1062; Eukaryota.
DR GeneTree; ENSGT00950000182838; -.
DR HOGENOM; CLU_003824_3_1_1; -.
DR InParanoid; M3WD28; -.
DR OMA; ADNNMEI; -.
DR OrthoDB; 25313at2759; -.
DR Proteomes; UP000011712; Chromosome B3.
DR Bgee; ENSFCAG00000010314; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0030124; C:AP-4 adaptor complex; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0140312; F:cargo adaptor activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR017109; AP4_complex_esu.
DR InterPro; IPR028269; AP4E1_C.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF13; AP-4 COMPLEX SUBUNIT EPSILON-1; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF14807; AP4E_app_platf; 1.
DR PIRSF; PIRSF037097; AP4_complex_epsilon; 1.
DR SMART; SM01356; AP4E_app_platf; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037097};
KW Membrane {ECO:0000256|PIRNR:PIRNR037097};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037097};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037097}.
FT DOMAIN 1032..1135
FT /note="AP-4 complex subunit epsilon-1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01356"
SQ SEQUENCE 1137 AA; 127671 MW; 2D1736875844D662 CRC64;
MSDIVEKTLT ALPGLFLQNQ SVGGSAGVKA SFSSRLGNLV RGITALTSKH EEEKLIQQEL
SNLKATVSAP TTTLRMMKEC MVRLIYCEML GYDASFGYIH AIKLAQQGNL LEKRVGYLAV
SLFLHESHEL LLLLVNTVVK DLQSTNLVEV CMALTVVSQI FPREMIPAVL PLIEDKLQHS
KEIIRRKAVL ALYKFHLIAP NQVQHIHIKF RKALCDRDVG VMAASLHIYF RMIKENSSGY
KDLTGSFVTI LKQVVGGKLP VDFNYHSVPA PWLQIQLLRI LGLLGKDDQR TSELMYDVLD
ESLRRAELNH NVTYAILFEC VHTVYSIYPK SELLEKAAKC IGRFVLSPKI NLKYLGLKAL
TYVIQQDPTL ALQHQMTIIE CLDHPDPIIK RETLELLYRI TNAQNITVIV QKMLEYLQQS
KEEYIIVNLV GKIAELAEKY APDNAWFIQT MNAVFSVGGD VMHPDIPNNF LRLLAEGFDD
ETENQQLRLY AVQSYLTLLD AENVFYPQKF LQVMSWVLGE YSYLLDEETP EEVITKLYKL
LMNDSVSSET KAWLLAAVTK LTPQAHSSNI VERLIQEFTV SLDTCMRQHA FELKHLRENV
ELMKSLLPVD KSCEDMVVDA SLSFLDGFVA EELSQGAAPY KPHHQRQEEK LSQEKVLNFE
PYGLSFSSSG FTGRQSPAGI SLGSDISGNS AETGLKETNS LKLEGIKKLW GKEGYLPKKE
GKTGDETEVP PVPQESIIME NVDQTIIKKD QSQVLTQSKE EKEKQLLASS LFVGLGTEST
INLLGKADTV SHKFRRKSKV KETKSGEKTS AQNMPCSYFS SSSDVTYEDD YYLDTLQDRG
DKELNKFSLN SELLDSESLT ELPSVEKLSS CTLSTPSLFT DDMEGLHSPS STAASVANEI
SLASSLLEET SEHMHSDLVE VCNNETISVS SYKIWKDDCL LVVWSVSNKS GLELKSADLE
ISSAENFKIT EQPGCCLPVI ETESIKTFQY SVQMEKPFTE GNLFGFINYQ MMDTHSVQLE
FSVNLSLLDF IRPLKISTEN FGKLWLSFAN DVKQNVKMSE SQAALPSALK TLQQKLRLHV
VEIIGNEGLL ACQLLPSIPC LLHFRVHGDV LALWFRSSCS TLPDYLLYQC QKVVEGS
//
