ID M3WD73_FELCA Unreviewed; 2632 AA.
AC M3WD73;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=Immunoglobulin superfamily member 10 {ECO:0000313|Ensembl:ENSFCAP00000009651.4};
GN Name=IGSF10 {ECO:0000313|Ensembl:ENSFCAP00000009651.4,
GN ECO:0000313|VGNC:VGNC:62894};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000009651.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000009651.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009651.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000009651.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009651.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000009651.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009651.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04001816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000009651; -.
DR PaxDb; 9685-ENSFCAP00000009651; -.
DR Ensembl; ENSFCAT00000010403.6; ENSFCAP00000009651.4; ENSFCAG00000010400.6.
DR VGNC; VGNC:62894; IGSF10.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158290; -.
DR HOGENOM; CLU_000580_0_0_1; -.
DR InParanoid; M3WD73; -.
DR OMA; VTWIMPD; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000010400; Expressed in uterus and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 9.
DR Pfam; PF13927; Ig_3; 3.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 12.
DR SMART; SM00408; IGc2; 12.
DR SMART; SM00406; IGv; 6.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 12.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 12.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..2632
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023923677"
FT DOMAIN 468..574
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 578..670
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1657..1748
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1754..1845
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1850..1942
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1950..2043
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2046..2144
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2150..2238
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2243..2340
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2346..2424
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2441..2527
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2537..2632
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1347..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2632 AA; 292541 MW; 6B83F94F8A8B307A CRC64;
MILFIFRMKV KGKGITSLLV LFSVLCLAAS PGGKACPRRC ACYVPTEVHC TFRYLTSIPD
SIPPNVERIN LGYNSLVRLT ETDFSGLNKL ELLLLHSNGI HTIPAKTFSD LQALQVLKMS
YNKIRKLQKD TFYGLRSLTR LHMDHNNIEF INPEVFYGLT FLRLVHLEGN QLTKLHPDTF
VSLQYLQIFK ISFIKYLYLS DNFLSTLPQQ MISYMPHLES LYLHGNPWTC DCHLQWLSDW
IQEKPDIIKC KKDRSPSSPQ QCPLCMNPRT SRGKPLAMVP AAAFLCAKPT IDPSLKLKNL
SILEDSNPVS ISPQDFMAPF GSLTLNMTDQ FGNEANMVCS IQKPSKTSSV VFAEENDYIM
LNTSFSTFLV CHIDYNHIQP VWQVLALYSD SPLILERSHW LTETPQRCYK YKQVAPKPED
IFTDIEAGLK ADPSWLMQDQ ISLQLNRTAT TLSTLHIQYS SDVQVTLPKA EIRPVKHKWT
MISRDNNTKL EHTILVGGTI GLDCQGQGDP TPHLEWLLAD GSKVRAPYVS EDGRILIDKS
GKLELQMADS FDTGIYHCIS TNYDDADILT YRITVVEPYI ETYHENGAHY TVFIGETLDL
PCHSSGIPDA SVSWVLPGNT MLYQSSGDKQ ILNNGTLRIL QVTQKNQGHY CCVAANPSGV
DFLINQVSVK TKGQRPVEHN VETDGSGFDE PNPIAHLKDP PAAQLPTSAS MGAEAGKGVF
STGKKHNYRG LIHRRRGDSL NRHFRDYRRP FSPSSRRIDP QHWAALLEKA KKNTMQEKQE
NTTAWPPPVV TQFLKIPGEE VDSSGMLPPD EEFMVLATKA PSVLARTLTA DSRKIHDSIV
TSITASTEVS PIVGPQILPP DKPIDFKLFP TTKTTAMSKN INPTISSKIQ STTNKNLSTI
FPLPPEATQF QEADNVGKKK EHLQSVLPKA AGAGTKDVNI KMLSGTNSKA DIFLGSVNAT
NSQQTSVTGV SEPRNNHFYP HITQKLSTSK LPSGTYTATH SQLQIPRNIT TNIPPTSRRF
GRRRKIWGRG RIISPYRTPI LRKHRYGFVR PTLRGASEES TTAFSATELD VLCPSCSPRE
RLTTTAAALS FASSSPILLT KAETAQVTAE ESTTLIHNPS FENKPNVDIE RTTPTIKYFR
AESIRVTPTG PVMTPAPKSL SLEKTHITNN GYPSVSNNIE VKRDSMIISP LPDPTTKSSM
STTTAMTRFL RRKIPWHQIF VNNHVQKERL KNQHQFSSPK STAPVFPKTS PALPTDKVFP
FHFTELSANV MQIPSITSAT THQNTTETHS PLSLPTMKKL PFPSLYPTPP NVSSKESSTN
FISMQTARLT ISPTDPASVI ISTTQIARPR TQKVQREKEP QNNRKEPHYA LSQSSGLTAS
TTMITPDLTA AETSTKPSVF AFTHSPLENT KEISSTTGLY PRTLTLTDII EELSQESTQT
LKSRIVSEIT LPSKPYQNAT RNTIIRHSTV PQILSSSAVP MPIPTSHPLN NQSTVTDNMA
TPVFRMMTNT MVKPLEHSRH NDNPQQLATE VAASPKVHLN AKVTIGTTHF IYSNLFHSTS
KPALVTVKSQ NSKLTSFPWS ENHFWHKSDP EIAEKGKKPI VDIMPTPGLP EDTTHASNWD
IQKTAKKNGF DKTPVQKTAT SELLPFDSLF RNTFERPRIV GGKAASFTVP ANSDAFLPCE
AVGNPLPTIH WTRVPSGFDM AKGKQNSRFQ VLPNGTLSIQ SVDIQDRGQY LCSASNPLGT
DRLHVTLSVV SYPPRILDRR TKEITVHSGN SVELKCRAEG RPSPTISWIL ANQTVVSESS
KGNRQALVTS DGTLVIHNLS IYDRGFYKCM ASNSAGQDSL LVKIQVIAAP PVILEQKRQI
IVGTWGESLK LPCTVKGTPQ PSVHWVLSDG TEVKPLQFIS SKLLLFSNGT LYIRNVASSD
RGTYECIATS TTGSERRVVI LTVEERETMP RIEFASQKWT EVNFGDKLLL NCSAIGEPKP
RIIWRLPSKA VVDQWHRMGS RIHVYPNGSL FIGSITEKDG GDYLCVARNK MGDDLILMHV
SLRLKPAKIY HKQHFKKQVF HGKDFQVDCE ASGSPVPEIS WTLPDGTMIN NAMQADDSGL
RTRRYTLFDN GTLYFNKVGI AEEGDYTCYA QNTLGKDEMK VHLTVITAAP RIRQGYKSNM
RIKAGDTAVL DCEVVGEPKP KVFWLLPSHD MISFSKDRYT FHANASLSIN KVQLLDSGEY
VCVARNPSGD DTKMYKLDVV SKPPLINGLY TNKTVIKATA VRHSKKHLDC RAEGTPLPQI
MWIMPDNIFL TAPYYGSRIT VHKNGTLEIR NVRLSDSADF ICVARNEGGE SMLVVQLEVL
EMLRRPTFRN PYNEKIVAQL GKSTALNCSV DGNPPPEIIW ILPNGTRFPN EPRISQYLIA
SNGSFIISKT TRDDAGKYRC AARNQVGYIE KLIVLEIGQK PVILTYALGT VYCFSGDSLS
LHCVSDGSPK PNIKWTTPSG YIIDGPQING KFILHENGTL VIKDATAYDR GNYICKAQNS
VGHALITVPV MVVAYAPRIT NRPPRSILTR TGAALQLLCV ALGVPKPEIT WEMPDHSLLS
MANKGRTHGI EPFQPRGTLI IQNPQTSDSG IYKCTARNPL GSDYATTYIQ VI
//
