ID M3WDH7_FELCA Unreviewed; 1938 AA.
AC M3WDH7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Myosin heavy chain 13 {ECO:0000313|Ensembl:ENSFCAP00000009804.5};
GN Name=MYH13 {ECO:0000313|Ensembl:ENSFCAP00000009804.5};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000009804.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000009804.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009804.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000009804.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009804.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000009804.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000009804.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AANG04000740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006939854.1; XM_006939792.3.
DR STRING; 9685.ENSFCAP00000009804; -.
DR PaxDb; 9685-ENSFCAP00000009804; -.
DR Ensembl; ENSFCAT00000010563.6; ENSFCAP00000009804.5; ENSFCAG00000009091.6.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000162543; -.
DR HOGENOM; CLU_000192_8_1_1; -.
DR InParanoid; M3WDH7; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000009091; Expressed in spleen and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0032982; C:myosin filament; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR CDD; cd14923; MYSc_Myh13; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR042702; Myh13_MYSc.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..782
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 659..681
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1884..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1901..1938
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1938 AA; 223216 MW; C2510BFAD8E4FF9E CRC64;
MSSDAEMAIF GEAAPYLRKP EKERIEAQNR PFDSKKACFA VDDKEMYVKG MIQSRENDKV
TVKTLDDRTL TLNSDQVFPM NPPKFDKIED MAMMTHLHEP AVLYNLKERY TAWMIYTYSG
LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR DNQSILITGE
SGAGKTVNTK RVIQYFATIA VTGDKKKEQQ PGKMQGTLED QIIQANPLLE AFGNAKTVRN
DNSSRFGKFI RIHFGATGKL ASADIETYLL EKSRVTFQLS SERSYHIFYQ IMSNKKPELI
DLLLISTNPF DFPFVSQGEV TVASIDDSKE LLATDNAIDI LGFSSEEKVG IYKLTGAVMH
YGNMKFKQKQ REEQAEPDGT EVADKAGYLM GLNSAEMLKG LCCPRVKVGN EYVTKGQNVQ
QVTNAVGALA KAVYEKMFLW MVTRINQQLD TKQPRQYFIG VLDIAGFEIF DFNSLEQLCI
NFTNEKLQQF FNHHMFVLEQ EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC
MFPKATDTSF KNKLYDQHLG KSNNFQKPKP AKGKAEAHFS LVHYAGTVDY NIAGWLDKNK
DPLNETVVGL YQKSSLKLLS FLFSNYAGAE AGDSGGSKKG GKKKGSSFQT VSAVFRENLN
KLMTNLRSTH PHFVRCLIPN ETKTPGVMDH YLVMHQLRCN GVLEGIRICR KGFPSRILYA
DFKQRYRILN ANAIPEGQFI DSKNASEKLL SSIDVDREQY RFGHTKVFFK AGLLGLLEEM
RDEKLVTLMT HTQAICRGYL MRVEFKKMME RRESIFCIQY NIRAFMNVKH WPWMNLFFKI
KPLLKSAEAE KEMATMKEDF ERAKEELARS EARRKELEEK MVTLLQEKND LQLQVQSETE
NLMDAEERCE GLIKSKIQLE AKVKELSERL EEEEEINSEL VAKKRNLEDK CSSLKRDIDD
LELTLTKVEK EKHATENKVK NLSEEMTALE ENISKLTKEK KSLQEAHQQT LDDLQVEEDK
VNGLIKINVK LEQQTDDLEG SLEQEKKLRA DLERMKRKLE GDLKMSQESI MDLENDKQQL
EEKLKKKEFD ISQLQTKIEE EQAHGLQLQK KIKELQARTE ELEEEIEAER ASRAKAEKQR
SDLSRELEEI SERLEEAGGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKH
ADSVAELGEQ IDNLQRVKQK LEKEKSELKM EIDDLASNME TVSKAKSNME RMCRTVEDQF
NEIKAKDDQQ TQLIHDLNMQ KARLQTQNGE LSHQVEEKES LISQLTKGKQ ALTQQLEELK
RQLEEETKAK NALAHALQSS RHDCDLLREQ YEEEQEGKAE LQRALSKANS EVAQWRTKYE
TDAIQRTEEL EEAKKKLAQR LQEAEENTEA VSAKCASLEK TKQRLQGEVD DLMLDLERTN
TARAILDRKQ RDLDKVLAEW KQKLDESQAE LEAAQKGSRS LSTEIFKMQN AYEEVVDQLE
TLRRENKNLQ EEISDLTEQI AETGKNLQEV EKTKKQVEQE KSDLQVALEE VEGSLEHEES
KILRIQLELS QVKSELDRRV TEKDEEIEQL KRNSQRAAEA MQSVLDAEIR SRNDALRLKK
KMEGDLNEME IQLGHSSRQV AETQKHLHAV QGQLKASQLH LDDALRSNED LKEQLAIVER
RNGLLLEELE ELKAALEQTE RTRRLSEQEL LDASDRVQLL NSQNTSLINT KKKLEADIAQ
CQAEVENSMQ ESRNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR
LDEAEQLALK GGKKQIQKLE NRVRELESEL DAEQKRGAEA LKGAHKYERK VKEMTYQAEE
DRKNILRLQD LVDKLQAKVK AYKRQAEEAE EQANTQMSKC RRVQHELEEA EERADIAESQ
VNKLRAKSRD VGSQKMEE
//
