GenomeNet

Database: UniProt
Entry: M3WE92_FELCA
LinkDB: M3WE92_FELCA
Original site: M3WE92_FELCA 
ID   M3WE92_FELCA            Unreviewed;      4917 AA.
AC   M3WE92;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   25-APR-2018, entry version 38.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSFCAP00000010183};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSFCAP00000010183};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010183, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000010183, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010183,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000010183}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010183};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000010183}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010183};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AANG03358854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03358863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000010183; -.
DR   Ensembl; ENSFCAT00000010964; ENSFCAP00000010183; ENSFCAG00000010961.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; M3WE92; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000011712; Chromosome D2.
DR   Bgee; ENSFCAG00000010961; -.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4237   4256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4457   4477       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4531   4550       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4660   4681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4718   4739       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4794   4817       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      272    329       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      337    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1323   1548       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3980   4015       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      458    478       {ECO:0000256|SAM:Coils}.
FT   COILED     3031   3051       {ECO:0000256|SAM:Coils}.
FT   COILED     3296   3316       {ECO:0000256|SAM:Coils}.
FT   COILED     4373   4393       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4917 AA;  558197 MW;  791C208969B4DDDD CRC64;
     RRETQHRKQD DEVVLQCTAT IHKEQQKLCL AAEGFGNRLC FLESTSNSKN VPPDLSICTF
     VLEQSLSVRA LQEMLANTVE KSEGKTCRWP TSTWKETAQG GGHRTLLYGH AILLRHSYSG
     MYLCCLSTSR SSTDKLAFDV GLQEDTTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS
     SERYLHLSYG NGSLHVDAAF QQTLWSVAPI SSGSEAAQGY LIGGDVLRLL HGHMDECLTV
     PSGEHGEEQR RLVPRGGGRG AEVLTVFVRW SGSHIRWGQP FRLRHVTTGK YLSLMEDKNL
     LLMDKEKADV KSTAFTFRSS KEKLDVGVRK EVDGMGTSEI KYGDSVCYIQ HINTGLWLTY
     QSVDVKSVRM GSIQRKAIMH HEGHMDDGLN LSRSQHEESR TARVIRSTVF LFNRFIRGLD
     ALSKKVKAST VDLPIESVSL SLQDLIGYFH PPDEHLEHED KQNRLRALKN RQNLFQEEGM
     INLVLECIDR LHVYSSAAHF ADVAGREGGE AWKSILNSLY ELLAALIRGN RKNCAQFSGS
     LDWLISRLER LEASSGILEV LHCVLVESPE ALNIIKEGHI KSIISLLDKH GRNHKVLDVL
     CSLCVCHGVA VRSNQHLICD NLLPGRDLLL QTRLVNHVSS MRPNIFLGVS EGSAQYKKWY
     YELMVDHTEP FVTAEATHLR VGWASTEGYS PYPGGGEEWG GNGVGDDLFS YGFDGLHLWS
     GCIARTVSSP NQHLLRTDDV ISCCLDLSAP SISFRINGQP VQGMFENFNI DGLFFPVVSF
     SAGIKVRFLL GGRHGEFKFL PPPGYAPCYE AVLPKEKLKV EHSREYKQER TYTRDLLGPT
     VSLTQAAFTP IPVDTSQIVL PPHLERIREK LAENIHELWV MNKIELGWQY GPVRDDNKRQ
     HPCLVEFSKL PEQERNYNLQ MSLETLKTLL ALGCHVGIAD EHAEEKVKKM KLPKNYQLTS
     GYKPAPMDLS FIKLTPSQEA MVDKLAENAH NVWARDRIRQ GWTYGIQQDV KNRRNPRLVP
     YTLLDDRTKK SNKDSLREAV RTLLGYGYHL EAPDQDHAAR AEVCSGTGER FRIFRAEKTY
     AVKAGRWYFE FEAVTAGDMR VGWSRPGCQP DQELGSDERA FAFDGFKAQR WHQGNEHYGR
     SWQAGDVVGC MVDMTEHTMM FTLNGEILLD DSGSELAFKD FDVGDGFIPV CSLGVAQVGR
     MNFGKDVSTL KYFTICGLQE GYEPFAVNTN RDITMWLSKR LPQFLQVPSN HEHIEVTRID
     GTIDSSPCLK VTQKSFGAQN STADIMFYRL SMPIECAEVF SKTVAGGLPG AGLFGPKNDL
     EDYDADSDFE VLMKTAHGHL VPDRVDKDKE ATKPEFNNHK DYAQEKPSRL KQRFLLRRTK
     PDYSTSHSAR LTEDVLADDR DDYDYLMQTS TYYYSVRIFP GQEPANVWVG WITSDFHQYD
     TGFDLDRVRT VTVTLGDEKG KVHESIKRSN CYMVCAGESM SPGQGRNNNG LEIGCVVDAA
     SGLLTFTANG KELSTYYQVE PSTKLFPAAF AQATSPNVFQ FELGRIKNVM PLSAGLFKSE
     HKNPVPQCPP RLHVQFLSHV LWSRMPNQFL KVDVSRISER QGWLVQCLDP LQFMSLHIPE
     ENRSVDILEL TEQEELLKFH YHTLRLYSAV CALGNHRVAH ALCSHVDEPQ LLYAIENKYM
     PGLLRAGYYD LLIDIHLSSY ATARLMMNSE FIVPMTEETK SITLFPDENK KHGLPGIGLS
     TSLRPRIQFS SPSFVSINND CYQYSPEFPL DILKAKTIQM LTEAVKEGSL HARDPVGGTT
     EFLFVPLIKL FYTLLIMGIF HNEDLKHILQ LIEPSVFKEA ATPEEDTEAL EKEPSMEDSK
     PEGAGEEEAK GGKRPKEGLL QMKLPEPVKL QMCLLLQYLC DCQVRHRIEA IVAFSDDFVA
     KLQDNQRFRY NEVMQALNMS AALTARKTKE FRSPPQEQIN MLLNFKDDKS ECPCPEEIRD
     QLLDFHEDLM THCGIELDED GSLDGNSDLT IRGRLLSLVE KVTYLKKKQA EKPVESGSKK
     SSTLQQLISE TMVRWAQESV IEDPELVRAM FVLLHRQYDG IGGLVRALPK TYTINGVSVE
     DTINLLASLG QIRSLLSVRM GKEEEKLMIR GLGDIMNNKV FYQHPNLMRA LGMHETVMEV
     MVNVLGGGES KEITFPKMVA NCCRFLCYFC RISRQNQKAM FDHLSYLLEN SSVGLASPAM
     RGSTPLDVAA ASVMDNNELA LALREPDLEK VVRYLAGCGL QSCPMLVSKG YPDIGWNPVE
     GERYLDFLRF AVFCNGESVE ENANVVVRLL IRRPECFGPA LRGEGGNGLL AAMEEAIKIA
     EDPSRDGPSP TSGSSKTLET EEEEDDTIHM GNAIMTFYAA LIDLLGRCAP EMHLIHAGKG
     EAIRIRSILR SLIPLGDLVG VISIAFQMPT IAKDGNVVEP DMSAGFCPDH KAAMVLFLDR
     VYGIEVQDFL LHLLEVGFLP DLRAAASLDT AALSATDMAL ALNRYLCTAV LPLLTRCAPL
     FAGTEHHASL IDSLLHTVYR LSKGCSLTKA QRDSIEVCLL SICGQLRPSM MQHLLRRLVF
     DVPLLNEHAK MPLKLLTNHY ERCWKYYCLP GGWGNFGAAS EEELHLSRKL FWGIFDALSQ
     KKYEQELFKL ALPCLSAVAG ALPPDYMESN YVSMMEKQSS MDSEGNFNPQ PVDTSNITIP
     EKLEYFINKY AEHSHDKWSM DKLANGWIYG EIYSDSSKVQ PLMKPYKLLS EKEKEIYRWP
     IKESLKTMLA WGWRVERTRE GDSMALYNRS RRISQTSQVS VDAAHGYSPR AIDMSNVTLS
     RDLHAMAEMM AENYHNIWAK KKKMELESKG GGNHPLLVPY DTLTAKEKAK DREKAQDILK
     FLQINGYAVS RGFKDLELDT PSIEKRFAYS FLQQLIRYVD EAHQYILEFD GGSRSKAEHF
     PYEQEIKFFA KVVLPLIDQY FKNHRLYFLS AASRPLCSGG HASNKEKEMH FVCSLGNDAT
     SIVNCLHILG QTLDARTVMK TGLESVKSAL RTFLDNAAED LEKTMENLKQ GQFTHTRNQP
     KGVTQIINYT TVALLPMLSS LFEHIGQHQF GEDLILEDVQ VSCYRILTSL YALGTSKSIY
     VERQRSALGE CLAAFAGAFP VAFLETHLDK HNIYSIYNTK SSRERAALNL PTNVEDVCPN
     IPSLEKLMEE IVELAESGIR YTQMPHVMEV ILPMLCSYMS RWWEHGPENN PERAEMCCTA
     LNSEHMNTLL GNILKIIYNN LGIDEGAWMK RLAVFSQPII NKVKPQLLKT HFLPLMEKLK
     KKAAMVVSEE DHLKAEARGD MSEAELLILD EFTTLARDLY AFYPLLIRFV DYNRAKWLKE
     PNPEAEDLFR MVAEVFIYWS KSHNFKREEQ NFVVQNEINN MSFLITDTKS KMSKAAVSDQ
     ERKKMKRKGD RYSTQTSLIV AALKRLLPIG LNICAPGDQE LIALAKNRFS MKDTEDEVRD
     IIRSNIHLQG KLEDPAIRWQ MALYKDLPNR TEDTSDPEKT VERVLDIANV LFHLEQVRFS
     MDSMVEHPQR SKKAVWHKLL SKQRKRAVVA CFRMAPLYNL PRHRAVNLFL QGYEKSWIET
     EEHYFEDKLI EDLAKPGADP PEEEEGTKRV DPLHQLILLF SRTALTEKWY GWDGSCHDEE
     DDDGEEEVKS FEEKEMEKQK LLYQQARLHD RGAAEMVLQT ISASKGDTGP MVAATLKLGI
     AILNGGNSTV QQKMLDYLKE KKDVGFFQSL AGLMQSCSVL DLNAFERQNK AEGLGMVTEE
     GSGEKVLQDD EFTCDLFRFL QLLCEGHNSD FQNYLRTQTG NNTTVNIIIS TVDYLLRVQE
     SISDFYWYYS GKDVIDEQGQ RNFSKAIQVA KQVFNTLTEY IQGPCTGNQQ SLAHSRLWDA
     VVGFLHVFAH MQMKLSQDSS QIELLKELMD LQKDMVVMLL SMLEGNVVNG TIGKQMVDML
     VESSNNVEMI LKFFDMFLKL KDLTSSDTFK EYDPDGKGVI SKRDFHKAME SHKHYTQSET
     EFLLSCAETD ENETLDYEEF VKRFHEPAKD IGFNVAVLLT NLSEHMPNDT RLQTFLELAE
     SVLNYFQPFL GRIEIMGSAK RIERVYFEIS ESSRTQWEKP QVKESKRQFI FDVVNEGGEK
     EKMELFVNFC EDTIFEMQLA AQISESDLNE RSANKEESEK EKPEEQGPRM GFFSIVTVKS
     ALFALRYNIL TLMRMLSLKS LKKQMKKVKK MTMKDMVTAA FSSYWSIFMS LLHFVASVSR
     GFFRIICSLL LGGSLVEGAK KIRVAELLAN MPDPTQDEVR GDGEEGDRRP MEAALPSEDL
     TDLKELTEES DLLSDIFGLD LKREGGQYKL IPHNPNAGLS DLMSNPVPIP DVQEKFQEQK
     VKEEEKEEKE ESKSEPEKAE GEDGEKEEKA KEDKGKQKLR QLHTHRYGEP EVPESAFWKK
     IIAYQQKLLN YFARNFYNMR MLALFVAFAI NFILLFYKVS TSSVVEGKEP PTRSSSGNAK
     VSSLDSGSPR IIAVHYVLEE SSGYMEPTLR ILAILHTVIS FFCIIGYYCL KVPLVIFKRE
     KEVARKLEFD GLYITEQPSE DDIKGQWDRL VINTQHYCAQ KFQDKKQTNK QTKTLISELL
     GMDKAALDFS DAREKKKPKK DSSLSAVLNS IDVKYQMWKL GVVFTDNSFL YLAWYMTMSV
     LGHYNNFFFA AHLLDIAMGF KTLRTILSSV THNGKQLVLT VGLLAVVVYL YTVVAFNFFR
     KFYNKSEDGD TPDMKCDDML TCYMFHMYVG VRAGGGIGDE IEDPAGDEYE IYRIIFDITF
     FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT VPHGFETHTL
     QEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWE FFPAGDCFRK QYEDQLN
//
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