ID M3WEH5_FELCA Unreviewed; 466 AA.
AC M3WEH5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=BCL2 like 13 {ECO:0000313|Ensembl:ENSFCAP00000010320.5};
GN Name=BCL2L13 {ECO:0000313|Ensembl:ENSFCAP00000010320.5,
GN ECO:0000313|VGNC:VGNC:60084};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010320.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000010320.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010320.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000010320.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010320.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000010320.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010320.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04001873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WEH5; -.
DR STRING; 9685.ENSFCAP00000010320; -.
DR PaxDb; 9685-ENSFCAP00000010320; -.
DR Ensembl; ENSFCAT00000011111.6; ENSFCAP00000010320.5; ENSFCAG00000011108.6.
DR VGNC; VGNC:60084; BCL2L13.
DR eggNOG; ENOG502R6AP; Eukaryota.
DR GeneTree; ENSGT00390000015552; -.
DR HOGENOM; CLU_032647_0_0_1; -.
DR InParanoid; M3WEH5; -.
DR OMA; MHEALQT; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000011108; Expressed in eyeball of camera-type eye and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR042398; BCL2L13.
DR PANTHER; PTHR15758; BCL-2-LIKE PROTEIN 13; 1.
DR PANTHER; PTHR15758:SF2; BCL-2-LIKE PROTEIN 13; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 441..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..194
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|Pfam:PF00452"
FT REGION 221..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 47..74
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 466 AA; 50891 MW; 8A9D03C787273641 CRC64;
MASSTTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ ASQSLDQEVL LKIKTEIEEE
LESLDKEISE AFTSTGFDRH TSPVFSPANP ESSVEDCLAH LGEKVLQELK EPLQKALQML
LSQPVTYQAY RECTLETTVH ASGWNKILVP LILLQQMLLE LTRRGQEPLS ALLQFGVTYL
EDYAAEYIIQ QGGWGTVFNL ESEEEEYPGI VAEDSNDIYI LPSDNSGQVS PPESPTVTTS
WQSESLPVSL SASQSWHTES LPVSLGPESW QQIAMDPEEV KSLDSNGAGE KSENNSSNSD
IVHVEKEEIP EGVEEAAVAS VVLPTKELQE AFPEAPAPLL PHITATSMLE VREPDTEAIA
VEKVSPATSL FVELDEEENL MKTKAAAVES VELEEEVIPA LEPTETLLSE KEMHVKRESL
QEGPSPAAEE KAFPLSEGKS ILLFGGAAAV AILAVAVGVA LALRKK
//
