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Database: UniProt
Entry: M3WEZ1_FELCA
LinkDB: M3WEZ1_FELCA
Original site: M3WEZ1_FELCA 
ID   M3WEZ1_FELCA            Unreviewed;      1550 AA.
AC   M3WEZ1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSFCAP00000010552};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010552, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000010552, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010552,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010552};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000010552}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010552};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AANG03018922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03018923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03018924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000010552; -.
DR   Ensembl; ENSFCAT00000011360; ENSFCAP00000010552; ENSFCAG00000011354.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3WEZ1; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C1.
DR   Bgee; ENSFCAG00000011354; -.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    103    126       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    235    259       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    374    392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    404    427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    439    463       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    483    508       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    576    596       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    856       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    868    885       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    927    949       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1035   1062       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1111   1138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1150   1168       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1180   1199       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1237   1265       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1341   1367       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       13    270       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      374    598       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      611    795       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      803   1067       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1119   1364       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1550 AA;  178255 MW;  17458B4A33DDBF7E CRC64;
     MPMTELPKWG PALQNTLLGI YTFEILIKLI ARGIWVEPFY FFGDPWNWLD FSVTLFEHVT
     RYLPLNFIPI FRITRNLRIL KIIPLNQGLK SFVRILTHCL KKLTGVIILT LFFLSVFSLI
     GMGLFMGNLK HKCLRWPQEN ETVTLHNRTE NPYYIRETEN FYYLEGEIYA LLCGNRTDAG
     QCPEGYVCVK AGTNPDYGFT NFDSFGWALL ALFRLMTQDY PEALYHQILY ASGKVYMIFF
     VVISFWFAFY IASLFLGILA MSCEEEKQKA AEKAEKTEPQ FQQTLKELQE GDKAAETKTT
     QIEMKKRSPT SMITSFNMLD DSTATVRHEE ELKKSRKRRP LCLYRFAKTL LIWNCSPCWL
     KLKAFIHMII MDPFTDLVLT ICIILNVCFL ALECYPMREE TTSVLSIGNL IFIGIFTAEM
     ILKIIAMHPY GYFQVGWNIF DSLIVFHGLA ELYLANVSGM AFLKIFRVLR IFKLGKYWPT
     FRILMLILSN SLVALKGLVL LLFTFMFFSA VVGLKLFGRS YKECVCNIDK DCQLPHWHMH
     DFFHSFLNVL RILCGEWIET LWDCLKVAGQ FGCLPFYMMV ILIGNLLIIY LFLALVSSFS
     SYKAPTTEEN GEEQNLQRAM ARIKKGINYV FPKISCKKQN ISKETMDNVN NVYVRENISD
     PTLSDVSNTQ DFFKDKEKSS GTEKNTMTEN ESQSLIPSPS VSETVPIASG ESDIENLDNK
     EIQSKSGDGS SKEKVKQSSS SECSTVDIAI SEEETVCEHE KPKQLKNGYR RRSSPGQISG
     ESKKGRIWQN IRKTCRKIVE NGCFKCFIGL VTLLSTGALA FEDIYIDQRK TIKILLEYAD
     MIFTYIFILE MLLKWMAYGF KAYFTDSWYK LDFMVVIVFC LSLIGKSREE FKPLISVKFL
     RALRVLSQFE RMKVVVRALI KTTLPALNVF LVCLMIWLAF SIIGVYLFAG TFYECIDPTS
     GERFPVSEVM NKSQCESLVF NESMQWENAK LNFDNVGNGF LSLLQVATFN GWITIMNSAV
     DSTGVNKQPN FEDNIYMSCY FISFIVIGLF LPLSMLIGVI IANFNKHKIK QGGSNIFITV
     KQKRQYHALR GLLHEDSQKI IRRPRNKFQR FMFDLVTSQV FNVFIMVLIC FQAITIMIQS
     DEQSSEMDTA LYWITLFLVM VYTGECVLKL ISFRCNYFTM GWNIFDFMVV IFSITGLFLP
     LMVGYYLVPP SVVQLILLSR IIHILRPGKG PKVFRDLLLP LMLSFPALLN ISLLIFLVMF
     VYAIFGMYNF AYVKKEFGIN DVANFETFGS SMLCLFQVTI FAGWDGMLNA IFNSKWSDCD
     PDKINPGTQV RGDCGNPFVG IIYFVSYIFI SWMIIVNMYI IAVMEFLNIA SKKKAKTLSE
     DDFKKFFQVW KRFDPDRTQY IDSSKLSDLA AALDPPLFMA KPNKGQLVAM DLPMAAGDRI
     HCLDILLALT KRVMGTDVRM EKVISEMESG FALANPFKIM YEPITTTLKR KQEAVSATII
     QRAYKNYRLR RNDKNTSDIH MIDDDKEVQA TTENAYFDKA EEKLTIQSQI
//
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