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Database: UniProt
Entry: M3WF33_FELCA
LinkDB: M3WF33_FELCA
Original site: M3WF33_FELCA 
ID   M3WF33_FELCA            Unreviewed;      1991 AA.
AC   M3WF33;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 38.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 6 {ECO:0000313|Ensembl:ENSFCAP00000010613};
GN   Name=TRPM6 {ECO:0000313|Ensembl:ENSFCAP00000010613};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010613, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000010613, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010613,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000010613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010613};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000010613}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010613};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   EMBL; AANG03361028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03361029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03361030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03361031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03361032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03361033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFCAT00000011425; ENSFCAP00000010613; ENSFCAG00000011422.
DR   eggNOG; ENOG410INBW; Eukaryota.
DR   eggNOG; ENOG410ZSH9; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; M3WF33; -.
DR   OMA; NERMAMK; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   Proteomes; UP000011712; Chromosome D4.
DR   Bgee; ENSFCAG00000011422; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029597; TRPM6.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF15; PTHR13800:SF15; 2.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    877    895       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    907    926       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    946    966       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1019   1042       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1719   1949       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
FT   COILED      662    682       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1991 AA;  227866 MW;  586B5FE365922C7B CRC64;
     MKRSQKSWIE GVFNKRECSK IIPSSKDPHR CTAGCQVCQN LIRCYCGRLI GDHHGIDYSW
     TISAANGNEN EQWSVEKHTT KSPTDTFGTI NFQDGEHTHH SKYIRTSYDT KADHLLHLML
     KEWKMELPKL VISVHGGIQN FRMPSKLKEI FSQGLVKAAE TTGAWIITEG INTGVSKHVG
     DALKAHSFRS LRKIWTVGIP PWGVIENQRD LIGKDVVCLY QTLGNPLSKL TTLNSMHSHF
     ILSDDGTVGK YGNEMNLRRN LEKYLSLQKI HSRSRQGVPV VGLVVEGGPN VILAVWETVK
     DKDPVVVCEG TGRAADLLAF THKHLADEGT LRPQVKEEII CMIQSTFNFS LKQSKHLFQI
     LMECMVHRDS MTIFDADSEE SPDLDLVILT ALLKGTNLAA SEQLNLAMAW DRMDIAKKHI
     LTYGQHWKPG TLEQAMLDAL VMDRVDFVKL LIEYGVNLHR FLTIPRLEEL YNTKQGPTNM
     LLHHLVRDVK QHALLSGYRI TLIDIGLVIE YLIGGAYRSS YTRKSFRALY NNLYRKRKVP
     QLQVTSFAES RSQPPLHRRR PSGNRKESAE STLHSQFIRT AQPYKFKEKS VVLHKSRKKS
     KEEQNISDDP ESTGFIYPYN DLLVWAVLMK RQKMAMFFWQ HGEEATVKAV IACKLYRAMA
     HEAKESNMVD DASEELKNYS KQFGQLALDV LEKAFKQNER MAMKLLTYEL KNWSDSTCLK
     LAVSGRLRPF VSHTCTQMLL TDMWTGRLKM RKHAWLKIII SILFPPTILS LEFKSKAEMS
     HVPQSQDFQF AWYYGDQNAS NAKESAYTKD RDLERGPDEK LDENQHFDLK SGPQSLPWTR
     KIYEFYNAPI VKFWFYTVCI SEPGKFTQKV KVWISEYWNL IETVAIGLFS VGFGLRWGDP
     PLHTAGRLIY CIDIIFWFSR LLDFFAVNQH VGPYVTMIAK MTANMFYIVI MMAIVLLSFG
     VARKAILSPK QLPSWSLARD IVFEPYWMIY GEVYASDIDV CASHPSCPPG SFLTPFLQAV
     YLFVQYIIMV NLLIAFFNNV YVDMKSISNK LWKYNRYRYI MTYHKKPWLP PPFILLSHVG
     LLLRRLCHHR APNDQDEGDV GLKLYLSEED LKRLHDFEEQ CVEIYFHEKM ERLNYSCEER
     IRVTSERVTE MYFQLKEMNE KVSFIKDSLL SLDSQVGHLQ DLSALTVDTL KVLSAVDTLQ
     EDEALLANRK HSTCRKLPHS WNNVICAGVL GSMEISGEKK YQYYSMPPSL LRSLARGQHT
     LRVQRGPLLE ITDIQRKASN VRDEQEKQDT ETSVVASGVS LYTQTHPKHG QFLLVPSYLK
     QVPFSEEIDL PLFRPSMEAG IDVMATEQVA QNEVPVHLTW QTPGISAQGS VAEPKERYES
     IAHTPAREDK GEQVPPTLIC TPAPTQVTSV PSQAESMQVG GGYVNWAFSE GDETGVFSLK
     KKWQTCLAST CSGEENDQCQ KQIRVRSLSD NSSSLAQSSD CSEVGPWLPP NTSFWINPFR
     RDRPFTRSHS LRFHKEEKLK ICRIKNLSRS SEIRQSAWIR TKMLIKDRRL SKKKKKTQGL
     QVPVIMVDTC SPNDQLNSEP GESNISEEEE CSKNWLTVSK YSQISLEPPI YQKMKTKEIE
     RHAVQVSDYL KQSQEDLSKN SLWNSRSTSF NRNSLLRSSN GVDKISASLK SPQEPHHHYS
     AIERNNLMRL SQTIPFTPIQ LFAGEEVTVY RLEESSPLNL GKSMSSWSQR GRAAMIQVLS
     REEMGGGLRK AMRVVSTWSE DDVLRPGQVF IVKSFLPEVV QSWHRIFQES TVLHLCLREI
     QQQRAAQKLI YTFNQVKPQT IPYTPRFLEV FLIYCHSANQ WLTIEKYMTG EFRKYNNNNG
     DEIAPSNTLE ELLLAFSHWT YEYTRGELLV LDLQGVGENL TDPSVIKPED KQSRGMVFGP
     ANLGEDAIRN FIAKHRCNSC CRKLKLPDLK RNDYSPGRLN STFGLDTKIE PAEGPPAREG
     GGNSPEDLTR L
//
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