ID M3WF75_FELCA Unreviewed; 824 AA.
AC M3WF75;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313|Ensembl:ENSFCAP00000010681.4};
GN Name=TRPV4 {ECO:0000313|Ensembl:ENSFCAP00000010681.4,
GN ECO:0000313|VGNC:VGNC:66598};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010681.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000010681.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010681.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000010681.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010681.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000010681.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010681.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AANG04002472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WF75; -.
DR SMR; M3WF75; -.
DR Ensembl; ENSFCAT00000011501.5; ENSFCAP00000010681.4; ENSFCAG00000011496.5.
DR VGNC; VGNC:66598; TRPV4.
DR eggNOG; KOG3676; Eukaryota.
DR GeneTree; ENSGT00940000158615; -.
DR HOGENOM; CLU_012795_1_0_1; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000011496; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR InterPro; IPR008348; TrpV4.
DR PANTHER; PTHR10582:SF4; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 4; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR PRINTS; PR01769; VRL2RECEPTOR.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 422..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 428..682
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 824 AA; 92615 MW; F8F2F0B53824B559 CRC64;
MADPSGGPHA GPGEVAETPG DESGTPGAEA FPLSSLANLF EGEDGSPSPS PADTSRPAGP
GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHPSDN
RRWRKKVIEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTTDLDGLL PFLLTHKKRL
TDEEFREPST GKTCLPKALL NLSSGRNDTI PVLLDIAERT GNMREFINSP FRDIYYRGEL
PLSLAACTNQ PHIVNYLTEN PHKKADMRRQ DSRGNTVLHA LVAIADNTRE NTKFVTKMYD
LLLLKCARLF PDSNLEAVLN NDGLSPLMMA AKTGKIGVFQ HIIRREVTDE DTRHLSRKFK
DWAYGPVYSS LYDLSSLDTC GEEASVLEIL VYNSKIENRH EMLAVEPINE LLRDKWRKFG
AVSFYINVVS YLCAMVIFTL TAYYQPLEGT PPYPYRTTVD YLRLAGEIIT LLTGILFFFT
NIKDLFMKKC PGVNSLFIDG SFQLLYFIYS VLVIVSAALY LAGIEAYLAV MVFALVLGWM
NALYFTRGLK LTGTYSIMIQ KILFKDLFRF LLVYLLFMIG YASALVSLLN PCANMKVCGE
DHTNCTVPTY PSCRDSETFS TFLLDLFKLT IGMGDLEMLS STKYPVVFII LLVTYIILTF
VLLLNMLIAL MGETVGQVSK ESKHIWKLQW ATTILDIERS FPVFLRKAFR SGEMVTVGKS
SDGTPDRRWC FRVDEVNWSH WNQNLGIISE DPGKSENYQY YGFSHTVGRL RRDRWSSVVP
RVVELNKNSN PDDVVVPLDN MGTPSCDGHQ QSYPPKWRTD AAPL
//
