ID M3WFL1_FELCA Unreviewed; 906 AA.
AC M3WFL1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Leptin receptor {ECO:0000313|Ensembl:ENSFCAP00000010861.5};
GN Name=LEPR {ECO:0000313|Ensembl:ENSFCAP00000010861.5,
GN ECO:0000313|VGNC:VGNC:68035};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010861.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000010861.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010861.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000010861.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010861.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000010861.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010861.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WFL1; -.
DR Ensembl; ENSFCAT00000011706.6; ENSFCAP00000010861.5; ENSFCAG00000011703.6.
DR VGNC; VGNC:68035; LEPR.
DR eggNOG; ENOG502RK5B; Eukaryota.
DR GeneTree; ENSGT00730000111209; -.
DR HOGENOM; CLU_008491_0_0_1; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000011703; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR InterPro; IPR041182; LEP-R_IGD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF109; LEPTIN RECEPTOR; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR Pfam; PF18589; ObR_Ig; 2.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 840..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 239..333
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 539..634
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 740..833
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 906 AA; 103195 MW; AAE6536F047C6560 CRC64;
MICQKFCVAL LHCEFIYLIT AFNLAYPITP WRFKLSCMPP NTTYDFLLPT GISKNTSNVN
EHYEAVVEAK FNSSSTYLSN LSSKTTFHCC LWSEEDKNCS VHADDVEGKA FVATVNSLVF
QQIGANWNIQ CWTKEDLELF ICYMESLFKN PFKAYDLKVH LLYVLPEVLE ESLPVPQKGS
FLTVQCNCSV RDSCECHVPV PAAKLNHTLL MYFKITSGGV IFQSPMMSVQ PINVVKPDPP
LGLHMEITDT GNLKISWSSP TLVPFQLQYQ VKYSENSSTN MRKADEIVSA TSLLVDSVLP
GSSYEVQVRG RRLDGPGLWS DWSAPLIFTT QDVIYFPPKI LTSVGSNVSF HCIYKNENKI
VSSKKIVWWM NLAEKIPQSQ YHVVGDHVSK VTFRSLKATK PRGKFTYDAI YCCNEHECHH
RYAELYVIDV NINISCETDG YLTQMTCRWS TNAIQSLVGS TLQLRYHRSS LYCSDVPSIH
PISESKDCHL QRDGFYECVF QPIFLLSGYT MWIRINHSLG SLDSPPTCVV PDSVVKPLPP
SSVKVEITVK IGLLKISWEK PVFPENNLKF QIRYGLSGKE VQWKMYEVHD AKSNSASVLV
PDLCAVYAVQ VRCKRLDGLG YWSNWSSPAY TVVTDIKVPT RGPEVWRIIN EDTTKKERNV
TLLWKPLMKN DSLCSVRKYV VKHHTSRNGT WSEDVGNHTQ FTFLWTEQAH SVTVLAVNSI
GASFVNFNLT FSWPMSKVNT VQSLSAYPLN SSCVFLSWKL SPSDYSLMYF ITEWKILNED
SETKWLRIPS SVKKYYIHDH FIPIEKYQFS LYPVFMEGVG KPKIINSFTP DDIEKRQNDA
GLYVIVPIII SSSILLLGTL LISHQRMKKI FWEDVPNPKN CSWAQGLNFQ KKMVCAKEPL
DGRSGQ
//
