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Database: UniProt
Entry: M3WG01_FELCA
LinkDB: M3WG01_FELCA
Original site: M3WG01_FELCA 
ID   M3WG01_FELCA            Unreviewed;      1841 AA.
AC   M3WG01;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=Plexin B2 {ECO:0000313|Ensembl:ENSFCAP00000011053.4};
GN   Name=PLXNB2 {ECO:0000313|Ensembl:ENSFCAP00000011053.4,
GN   ECO:0000313|VGNC:VGNC:68919};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011053.4, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000011053.4, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011053.4,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000011053.4, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011053.4,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000011053.4}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011053.4};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the plexin family.
CC       {ECO:0000256|ARBA:ARBA00010297}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AANG04003413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011282666.1; XM_011284364.2.
DR   RefSeq; XP_019691325.1; XM_019835766.1.
DR   STRING; 9685.ENSFCAP00000011053; -.
DR   PaxDb; 9685-ENSFCAP00000011053; -.
DR   Ensembl; ENSFCAT00000011916.6; ENSFCAP00000011053.4; ENSFCAG00000011914.6.
DR   GeneID; 101099059; -.
DR   KEGG; fca:101099059; -.
DR   CTD; 23654; -.
DR   VGNC; VGNC:68919; PLXNB2.
DR   eggNOG; KOG3610; Eukaryota.
DR   GeneTree; ENSGT01020000230394; -.
DR   HOGENOM; CLU_001436_1_1_1; -.
DR   InParanoid; M3WG01; -.
DR   OMA; EYVFHND; -.
DR   OrthoDB; 1387371at2759; -.
DR   Proteomes; UP000011712; Chromosome B4.
DR   Bgee; ENSFCAG00000011914; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0002116; C:semaphorin receptor complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017154; F:semaphorin receptor activity; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IEA:Ensembl.
DR   GO; GO:1904861; P:excitatory synapse assembly; IEA:Ensembl.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR   GO; GO:0007162; P:negative regulation of cell adhesion; IBA:GO_Central.
DR   GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR   GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0050772; P:positive regulation of axonogenesis; IBA:GO_Central.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR   GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR   GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IBA:GO_Central.
DR   CDD; cd01180; IPT_plexin_repeat1; 1.
DR   CDD; cd01179; IPT_plexin_repeat2; 1.
DR   CDD; cd12792; RasGAP_plexin_B2; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR031148; Plexin.
DR   InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR   InterPro; IPR046800; Plexin_RBD.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR041019; TIG1_plexin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR22625; PLEXIN; 1.
DR   PANTHER; PTHR22625:SF9; PLEXIN-B2; 1.
DR   Pfam; PF08337; Plexin_cytopl; 1.
DR   Pfam; PF20170; Plexin_RBD; 1.
DR   Pfam; PF01437; PSI; 2.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 2.
DR   Pfam; PF17960; TIG_plexin; 1.
DR   SMART; SM00429; IPT; 3.
DR   SMART; SM00423; PSI; 3.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF81296; E set domains; 3.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1841
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014189694"
FT   DOMAIN          8..468
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
SQ   SEQUENCE   1841 AA;  204846 MW;  C443A240BAE1CC19 CRC64;
     MSLQLWALAL LGLVGASAGL RPRKLDFFRS ETELNHLVVD EASGVVYVGA VNALYQLSAS
     LQLEQQAATG PALDNKKCTP PIEASQCHEA VLTDNVNQLL LLDPPGKRLI ECGSLFKGIC
     ALRALSNISV RLFYEDGSGE KSFVASNDES VATVGLVSAT SPGGERVLFV GKGNGPHDNG
     IIVSTRLLDR TEGREAFEAY TDHATYKAGY LSTNTQQFVA AFEDGLYVFF VFNQQDKHPP
     RNRTLLARMC KQDPFYYSYL ETDLRCLDPA DPQAPAFGTC LAASVGVPSA GRVLYAVFSR
     DGRSGGGPRA GLCLFPLDEV HAKMEASRNA CYTGTREAGR DTFYKPFHGE IQCGGHGLGA
     SESFPCGSEH LPYPLGSRDG LTATAVLQRG GLNLTAVMVT AENGHTVAFL GTSDGRVLKV
     YLAPDGSSAE YGSILVEINK RIQRDLVLSA DLASLYALTQ DKVFRLPVQE CLSYTTCTQC
     HSSQDPYCGW CVVEGRCTRR AECPRAEEHG HWLWSRDESC VAITGAQPQN MSRRAQGEVQ
     LSVSPLPALS EDDELLCLFG DSPPHPARVE GDAIICNSPS SIPGTPPGQD HVAVNIQLLF
     RRGSIFLTSH LYPFYDCREA MSLAENLPCI SCSSNRWTCQ WDLRYRECRE ASPNPEAGIV
     PAHMEDSCPQ FLNPSPLVIP MNHETDVTFQ GKNLDTVKGS SLYVGSELLK FEEPVSTQEP
     GTFFFRTPKL SHDANETLPL HLYVKSYGKN VDSKLQVTLY NCSFGRSDCS LCLAADPVYK
     CVWCGGQSRC VYEALCSNAT SECPPPVITR IHPETGPLGG GIRITILGSN LGVRADDVKR
     ITVAEQNCVF QPERYSVSTR IVCTIDAAKT PITAGVVVDV NGKLGHSPPH VLFTYQQPQP
     LSVEPKQGPQ AGGTTLTING THLDTGSEED VRVTLNDVPC KVTQFGAQLQ CVTGPQAALG
     ELPLEIYYGG SRVPSPGVVF TYRENPVLRA FEPLRSFVSG GRSINVTGQG FSLIQRFAMV
     VIAEPLQSWR RRREAGPLQP TTVVGTEYMF HNDSKVVFLS PAVPEEPEAY NLTALIQMDG
     HRALLRTEAG AFEYVADPTF ENFTGGVKKQ VNKLIHARGT NLNKAMTLHE AEAFVGAERC
     IMKTLTETDL YCEPPEVQPP PKRRQKRDTT HNLPEFIVKF GSREWVLGRV EYDTRVSDVP
     LNLILPLVIV PMVAVIVVSV YCYWRKSQQA EREYEKIKSQ LEGLEESVRD RCKKEFTDLM
     IEMEDQTNDV HEAGIPVLDY KTYTDRVFFL PSKDGDKDVM ITGRLDIPES RRPVVEQALY
     QFSNLLNSKS FLVTFIHTLE SQREFSARAK VYFASLLTVA LHGKLEYYTD IMRTLFLELM
     EQYVVAKNPK LMLRRSETVV ERMLSNWMSI CLYQYLKDSA GEPLYKLFKA IKHQVEKGPV
     DAVQKKAKYT LNDTGLLGDD VEYAPLTVSV IVQDEGADAV PVKVLNCDTI SQVKEKIIDQ
     VYRTQPCSRW PKADSVVLEW RPGSTAQILS DLDLTSQREG RWKRVNTLMH YNVRDGATLI
     LSTVGVSQQP EDSQPDLPGE RHALLEEENR VWHLVRPAEE VDEGKSKRGS VKEKERTKAI
     TEIYLTRLLS VKGTLQQFVD NFFQSVLAPG HAVPPAVKYF FDFLDEQAEK HDIKDDDTIH
     IWKTNSLPLR FWVNILKNPH FIFDVHVHEV VDASLSVIAQ TFMDACTRTE HKLSRDSPSN
     KLLYAKEIST YKKMVEDYYK GIRQMVQVSD QDMNTHLAEI SRAHTDSLNT LVALHQLYQY
     TQKYYDEIIN ALEEDPAAQK MQLAFRLQQI AAALENKVTD L
//
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