ID M3WG01_FELCA Unreviewed; 1841 AA.
AC M3WG01;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Plexin B2 {ECO:0000313|Ensembl:ENSFCAP00000011053.4};
GN Name=PLXNB2 {ECO:0000313|Ensembl:ENSFCAP00000011053.4,
GN ECO:0000313|VGNC:VGNC:68919};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011053.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011053.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011053.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011053.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011053.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011053.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011053.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AANG04003413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011282666.1; XM_011284364.2.
DR RefSeq; XP_019691325.1; XM_019835766.1.
DR STRING; 9685.ENSFCAP00000011053; -.
DR PaxDb; 9685-ENSFCAP00000011053; -.
DR Ensembl; ENSFCAT00000011916.6; ENSFCAP00000011053.4; ENSFCAG00000011914.6.
DR GeneID; 101099059; -.
DR KEGG; fca:101099059; -.
DR CTD; 23654; -.
DR VGNC; VGNC:68919; PLXNB2.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR InParanoid; M3WG01; -.
DR OMA; EYVFHND; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000011914; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0002116; C:semaphorin receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:1904861; P:excitatory synapse assembly; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IBA:GO_Central.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IBA:GO_Central.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IBA:GO_Central.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd12792; RasGAP_plexin_B2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF9; PLEXIN-B2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1841
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014189694"
FT DOMAIN 8..468
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1841 AA; 204846 MW; C443A240BAE1CC19 CRC64;
MSLQLWALAL LGLVGASAGL RPRKLDFFRS ETELNHLVVD EASGVVYVGA VNALYQLSAS
LQLEQQAATG PALDNKKCTP PIEASQCHEA VLTDNVNQLL LLDPPGKRLI ECGSLFKGIC
ALRALSNISV RLFYEDGSGE KSFVASNDES VATVGLVSAT SPGGERVLFV GKGNGPHDNG
IIVSTRLLDR TEGREAFEAY TDHATYKAGY LSTNTQQFVA AFEDGLYVFF VFNQQDKHPP
RNRTLLARMC KQDPFYYSYL ETDLRCLDPA DPQAPAFGTC LAASVGVPSA GRVLYAVFSR
DGRSGGGPRA GLCLFPLDEV HAKMEASRNA CYTGTREAGR DTFYKPFHGE IQCGGHGLGA
SESFPCGSEH LPYPLGSRDG LTATAVLQRG GLNLTAVMVT AENGHTVAFL GTSDGRVLKV
YLAPDGSSAE YGSILVEINK RIQRDLVLSA DLASLYALTQ DKVFRLPVQE CLSYTTCTQC
HSSQDPYCGW CVVEGRCTRR AECPRAEEHG HWLWSRDESC VAITGAQPQN MSRRAQGEVQ
LSVSPLPALS EDDELLCLFG DSPPHPARVE GDAIICNSPS SIPGTPPGQD HVAVNIQLLF
RRGSIFLTSH LYPFYDCREA MSLAENLPCI SCSSNRWTCQ WDLRYRECRE ASPNPEAGIV
PAHMEDSCPQ FLNPSPLVIP MNHETDVTFQ GKNLDTVKGS SLYVGSELLK FEEPVSTQEP
GTFFFRTPKL SHDANETLPL HLYVKSYGKN VDSKLQVTLY NCSFGRSDCS LCLAADPVYK
CVWCGGQSRC VYEALCSNAT SECPPPVITR IHPETGPLGG GIRITILGSN LGVRADDVKR
ITVAEQNCVF QPERYSVSTR IVCTIDAAKT PITAGVVVDV NGKLGHSPPH VLFTYQQPQP
LSVEPKQGPQ AGGTTLTING THLDTGSEED VRVTLNDVPC KVTQFGAQLQ CVTGPQAALG
ELPLEIYYGG SRVPSPGVVF TYRENPVLRA FEPLRSFVSG GRSINVTGQG FSLIQRFAMV
VIAEPLQSWR RRREAGPLQP TTVVGTEYMF HNDSKVVFLS PAVPEEPEAY NLTALIQMDG
HRALLRTEAG AFEYVADPTF ENFTGGVKKQ VNKLIHARGT NLNKAMTLHE AEAFVGAERC
IMKTLTETDL YCEPPEVQPP PKRRQKRDTT HNLPEFIVKF GSREWVLGRV EYDTRVSDVP
LNLILPLVIV PMVAVIVVSV YCYWRKSQQA EREYEKIKSQ LEGLEESVRD RCKKEFTDLM
IEMEDQTNDV HEAGIPVLDY KTYTDRVFFL PSKDGDKDVM ITGRLDIPES RRPVVEQALY
QFSNLLNSKS FLVTFIHTLE SQREFSARAK VYFASLLTVA LHGKLEYYTD IMRTLFLELM
EQYVVAKNPK LMLRRSETVV ERMLSNWMSI CLYQYLKDSA GEPLYKLFKA IKHQVEKGPV
DAVQKKAKYT LNDTGLLGDD VEYAPLTVSV IVQDEGADAV PVKVLNCDTI SQVKEKIIDQ
VYRTQPCSRW PKADSVVLEW RPGSTAQILS DLDLTSQREG RWKRVNTLMH YNVRDGATLI
LSTVGVSQQP EDSQPDLPGE RHALLEEENR VWHLVRPAEE VDEGKSKRGS VKEKERTKAI
TEIYLTRLLS VKGTLQQFVD NFFQSVLAPG HAVPPAVKYF FDFLDEQAEK HDIKDDDTIH
IWKTNSLPLR FWVNILKNPH FIFDVHVHEV VDASLSVIAQ TFMDACTRTE HKLSRDSPSN
KLLYAKEIST YKKMVEDYYK GIRQMVQVSD QDMNTHLAEI SRAHTDSLNT LVALHQLYQY
TQKYYDEIIN ALEEDPAAQK MQLAFRLQQI AAALENKVTD L
//