ID M3WGD0_FELCA Unreviewed; 710 AA.
AC M3WGD0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSFCAP00000011241.6};
GN Name=ECM2 {ECO:0000313|Ensembl:ENSFCAP00000011241.6,
GN ECO:0000313|VGNC:VGNC:61712};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011241.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011241.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011241.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011241.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011241.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011241.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011241.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WGD0; -.
DR STRING; 9685.ENSFCAP00000011241; -.
DR PaxDb; 9685-ENSFCAP00000011241; -.
DR Ensembl; ENSFCAT00000012121.6; ENSFCAP00000011241.6; ENSFCAG00000012118.6.
DR VGNC; VGNC:61712; ECM2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159941; -.
DR HOGENOM; CLU_000288_186_2_1; -.
DR InParanoid; M3WGD0; -.
DR OMA; MTMYNRA; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000012118; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0070052; F:collagen V binding; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IBA:GO_Central.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR043184; ECM2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46544:SF1; EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR46544; EXTRACELLULAR MATRIX PROTEIN 2-RELATED; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..710
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023919749"
FT DOMAIN 99..156
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 24..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..302
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 80124 MW; F384C728848C68A2 CRC64;
MKFAGLVCFL LLIICQTDFG QNEEAPRKQR RKMHHRRLRG SSSPARRSSR QLGDQRTMVT
PGATRPVLNL DYSTEEKFDS FLGFLGVESS YNVLPGKKGH CLVNGMTMYN KAVWSPEPCT
TCLCSNGRVL CDETVCPPLT CPQTITPEGE CCPVCVDTAS PQPLSGTAIS DTSEISGDSS
EQREATNSPC KQLPSCPLEM NPVLQKEELR FEEDEEEIKE DKDKEQKKQT ADPGEQGRPF
SEGQSREGGE QRPHEEGRQA HQRGHPAREE EEEEEEEEKE EGEREDNDDE EEDGDDEEEH
DDTIRGDVFR MPSRPRVPPS PRRMPPLPSG CSLSYRTISC MSAGLTQMPP LTAPEITSLE
LAGNAITSIP DEAFNGLPNL KRLDLSKNNI TSPGIGPKAF KLLKKLLRLN MDGNNLVEIP
PDLPSALEEL KINDNSLQAI SEESLSDLNQ LVTLELEGNN LSESNVNPLA FKSLKSLSYL
RLGRNKFRII PQGLPASIEE LYLENNQIEE ITEICFNHTR KINVIVLRYN KIEENRIAPL
AWINQENLES IDLSYNKLYH VPSYLPKSLL HLVLLGNQIE RIPGYVFGHM EPGLEYLYLS
FNRLSDDGMD RVSFYGAYHS LRELFLDHND LKSIPPGVQE MKALHFLRLN NNKIRNILPE
QICNAEEDGD STLEHLHLEN NYIKTREISS YAFSCIRSYS SIVLKPQNIT
//
