ID M3WGD5_FELCA Unreviewed; 383 AA.
AC M3WGD5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Malonyl-CoA-acyl carrier protein transacylase {ECO:0000313|Ensembl:ENSFCAP00000011249.4};
GN Name=MCAT {ECO:0000313|Ensembl:ENSFCAP00000011249.4,
GN ECO:0000313|VGNC:VGNC:63410};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011249.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011249.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011249.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011249.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011249.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011249.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011249.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC Evidence={ECO:0000256|ARBA:ARBA00023404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41793;
CC Evidence={ECO:0000256|ARBA:ARBA00023404};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
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DR EMBL; AANG04001989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WGD5; -.
DR STRING; 9685.ENSFCAP00000011249; -.
DR PaxDb; 9685-ENSFCAP00000011249; -.
DR Ensembl; ENSFCAT00000012129.6; ENSFCAP00000011249.4; ENSFCAG00000012127.6.
DR VGNC; VGNC:63410; MCAT.
DR eggNOG; KOG2926; Eukaryota.
DR GeneTree; ENSGT00390000013715; -.
DR HOGENOM; CLU_030558_2_1_1; -.
DR InParanoid; M3WGD5; -.
DR OMA; AANYNCP; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000012127; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR PANTHER; PTHR47170; MALONYL-COA ACP TRANSACYLASE, ACP-BINDING; 1.
DR PANTHER; PTHR47170:SF2; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 66..379
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
SQ SEQUENCE 383 AA; 41747 MW; A7E8197914528246 CRC64;
MSVRVARVAW ARDWGAGCRR GVSNFPLPPS GAVNVAELLR DATAAEEGPR EAAARRRPPG
QCSVLLFPGQ GSQVVGMGRG LLGYPRVREL YAAARSVLGY DLLELSLHGP QEALDRTVHC
QPAVFVASLA AVEKLHHLQP AVIENCVAAA GFSVGEFAAL VFAGAMEFSE GLRAVKIRAE
AMQEASEAVP SGMLSVLGQP QSKFTFACLE AREHCKTLGI ENPVCEVASY LFPDCRVISG
HLEALRFLRK NSSKYHFRRT KMLPVSGGFH TRLMEPALEP LAQVLKSVAV KEPLVAVHSN
VDGNRYRHPK HIRKLLAQQV VSPVKWEQTM HAVYGRRKGT GFPETFEVGP GKQLGSILKS
CNLQAWRSYG HVEVLEDPED DGT
//
