ID M3WHJ4_FELCA Unreviewed; 971 AA.
AC M3WHJ4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Reversion inducing cysteine rich protein with kazal motifs {ECO:0000313|Ensembl:ENSFCAP00000011832.4};
GN Name=RECK {ECO:0000313|Ensembl:ENSFCAP00000011832.4,
GN ECO:0000313|VGNC:VGNC:64561};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011832.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011832.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011832.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011832.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011832.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011832.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011832.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AANG04001372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011286854.1; XM_011288552.2.
DR AlphaFoldDB; M3WHJ4; -.
DR STRING; 9685.ENSFCAP00000011832; -.
DR PaxDb; 9685-ENSFCAP00000011832; -.
DR Ensembl; ENSFCAT00000012764.6; ENSFCAP00000011832.4; ENSFCAG00000012761.6.
DR GeneID; 101088789; -.
DR KEGG; fca:101088789; -.
DR CTD; 8434; -.
DR VGNC; VGNC:64561; RECK.
DR eggNOG; KOG3649; Eukaryota.
DR GeneTree; ENSGT00390000018540; -.
DR HOGENOM; CLU_013883_0_0_1; -.
DR InParanoid; M3WHJ4; -.
DR OMA; PCKEACD; -.
DR OrthoDB; 2902241at2759; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000012761; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990909; C:Wnt signalosome; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:Ensembl.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:Ensembl.
DR GO; GO:0001955; P:blood vessel maturation; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0045765; P:regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0090210; P:regulation of establishment of blood-brain barrier; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IBA:GO_Central.
DR Gene3D; 3.30.60.30; -; 2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR039016; RECK.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR13487:SF3; REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS; 1.
DR PANTHER; PTHR13487; SERINE PROTEASE INHIBITOR; 1.
DR Pfam; PF07648; Kazal_2; 3.
DR SMART; SM00280; KAZAL; 3.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 3.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS51318; TAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..971
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014175737"
FT DOMAIN 627..673
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 971 AA; 106558 MW; 0CB1F724E7A6A6A2 CRC64;
MAVVPASRRG ALLLLLAVAE VAEVAGGLAP GSAGALCCNH SKDNQMCHDV CEQIFSSKSE
SRLKHLLQRA PDYCPETMVE IWSCMNSSLP GVFKKSDGWV GLGCCELAIT LECRQACKQA
SSKNDISKVC RKEYENALFS CISRNEMGSV CCSYAGHHTN CREYCQAIFR TDSSPGPSQI
KAVENYCASI SPQLIHCVNN YTQSYPMRNP TDSLYCCDRA EDHACQNACK RILMSKKTEM
EIVDGLIEGC KTQPLPQDPL WQCFLESSQS VHPGVTLHPP PSTGLDGAKL HCCSKANTST
CRELCTKLYS MSWGNTQSWQ EFDRFCEYNP VEVSMLTCLA DVREPCQLGC RNLTYCTNFN
NRPTELFRSC NAQSDQGAMN DMKLWEKGSI KMPFINIPVL DIKKCQPEMW KAVACSLQIK
PCHRKSRGSI ICKSDCVEIL KKCGDQNKFP EDHTAESICE LLSPTDDLEN CIPLDTYLRP
STLGNIIEEV THPCNPNPCP ANELCEVNRK GCPSGDPCLP YSCVQGCKLG EASDFIVRQG
TLIQVPSSAG EVGCYKICSC GQSGLLENCM EMHCIDLQKS CIVGGKRKSH GTSFNIDCNI
CSCFAGNLVC STRLCLSEHS SEDDRRTFTG LPCNCADQFV PVCGQNGRTY PSACIARCVG
LQDHQFEFGS CISKDPCNPN PCPKNQRCIP KPQVCLTTFD KFGCSQHECL PRQLTCDQVR
DPVCDTHHME HSSLCALYQR GQSLLYKGPC QPFCRATEPV CGHNGETYSS VCAAYSDRVA
VDYYGPCQAV GVLSEYSSVA ECAAVKCPSL SATECKPIIP PGACCPLCAG MLRVLFDKEK
LDTIAKVTNK KPITVLEILQ KIRMHVSVPQ CDVFGYFSIE SEIVILIIPV DHYPKALQIE
ACNKEAEKIE SLINSDSPTL ASHVPLSALI ISQVQVSNSV PSAGIEARAP CPPFLLLLSL
GPALHTVWTR N
//
