ID M3WHT1_FELCA Unreviewed; 193 AA.
AC M3WHT1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Ganglioside GM2 activator {ECO:0000313|Ensembl:ENSFCAP00000011944.5};
GN Name=GM2A {ECO:0000313|Ensembl:ENSFCAP00000011944.5,
GN ECO:0000313|VGNC:VGNC:62603};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011944.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011944.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011944.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011944.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011944.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011944.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011944.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WHT1; -.
DR STRING; 9685.ENSFCAP00000011944; -.
DR PaxDb; 9685-ENSFCAP00000011944; -.
DR Ensembl; ENSFCAT00000012885.5; ENSFCAP00000011944.5; ENSFCAG00000012881.5.
DR VGNC; VGNC:62603; GM2A.
DR eggNOG; ENOG502S05S; Eukaryota.
DR GeneTree; ENSGT00390000003288; -.
DR HOGENOM; CLU_108261_0_0_1; -.
DR InParanoid; M3WHT1; -.
DR OMA; WIKVPCV; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000012881; Expressed in tip of external ear and 10 other cell types or tissues.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:Ensembl.
DR GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central.
DR GO; GO:0007611; P:learning or memory; IEA:Ensembl.
DR GO; GO:0019915; P:lipid storage; IEA:Ensembl.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0051651; P:maintenance of location in cell; IEA:Ensembl.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR GO; GO:0009313; P:oligosaccharide catabolic process; IEA:Ensembl.
DR Gene3D; 2.70.220.10; Ganglioside GM2 activator; 1.
DR InterPro; IPR028996; GM2-AP.
DR InterPro; IPR036846; GM2-AP_sf.
DR InterPro; IPR003172; ML_dom.
DR PANTHER; PTHR17357:SF0; GANGLIOSIDE GM2 ACTIVATOR; 1.
DR PANTHER; PTHR17357; GM2 GANGLIOSIDE ACTIVATOR PROTEIN; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF63707; Ganglioside M2 (gm2) activator; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..193
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023881399"
FT DOMAIN 36..188
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
SQ SEQUENCE 193 AA; 20943 MW; 41DAF20112C98330 CRC64;
MSPQVQAPLL ILLVLLFASP VAPEFVFLKQ LSSFSWDNCD EGKDPAVIKS LTLEPDPIAF
PGNLTVSVEA RTEVPLTSPQ KVELTVEKEV AGFWAKVPCV EQIGSCTYED FCQIIDTVIP
PGEPCPEPLH TYGLPCHCPF KAGVYSLPES DFTLPQLEVP GWLSSGHYRI KTVLSSGGER
LGCVKISASL KGK
//
