ID M3WIJ4_FELCA Unreviewed; 839 AA.
AC M3WIJ4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Colony stimulating factor 3 receptor {ECO:0000313|Ensembl:ENSFCAP00000012306.6};
GN Name=CSF3R {ECO:0000313|Ensembl:ENSFCAP00000012306.6,
GN ECO:0000313|VGNC:VGNC:61217};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000012306.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000012306.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012306.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000012306.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012306.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000012306.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012306.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AANG04003369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WIJ4; -.
DR STRING; 9685.ENSFCAP00000012306; -.
DR PaxDb; 9685-ENSFCAP00000012306; -.
DR Ensembl; ENSFCAT00000013274.6; ENSFCAP00000012306.6; ENSFCAG00000013269.6.
DR VGNC; VGNC:61217; CSF3R.
DR eggNOG; ENOG502QT3H; Eukaryota.
DR GeneTree; ENSGT00940000158915; -.
DR HOGENOM; CLU_017990_0_0_1; -.
DR InParanoid; M3WIJ4; -.
DR OMA; SYCSIPR; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000013269; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0051916; F:granulocyte colony-stimulating factor binding; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0045637; P:regulation of myeloid cell differentiation; IEA:Ensembl.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF103; GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..839
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023844245"
FT TRANSMEM 626..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..230
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 236..332
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 431..525
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 527..624
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 734..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 92647 MW; FFB0DBBB8791D49D CRC64;
MVELGTWSLT RAALIILLLP RSLEECGHIS LPTSAVRLGD SITASCTISP NCSHLGPESQ
ILWKLGTQLQ LGERQQRLAD GSQESTITLP PLNRPRDLLS CCLRWGNSVQ ILDQAELWAG
YPPAAPHNLS CLMNLTTNSL ICQWEPGPHN HLPTNFTLKS FKSRDNCQTQ EDSILDCVPK
DGDSHCSIPR KYLKLYRHMG IWVQAENALG TGKSPQLCLV PMDVVKLEPP TLWALAPSPE
VAPPQPGCLL LRWELWKPSL YIEQKCELRH QPQLGEASWA LVGPLLPETL QYELCGLLPS
TAYVLQMRCV RWPLPGQWSD WSPSLILTTA QQAPIVRLDT WWRQRQLDPR TVDVQLFWKP
VPLDKYSGQI QGYLVRPPGQ TGAVPALCNT TELSCTFHLP SEAREVVLVA YNTAGTSHPT
PVVFLESRGP PLARLHTTAR DPHSLWVGWE PPSPRPRGYV IAWGLGPPSP SSSNMTWKME
HNGNISGTLL QENIRPFQLY EITVTPLYQD TVGPSQHIYA YSQEMAPSHT PELHLKHIGK
TWAQLEWEPQ APELGKSPLT HYTVFWTNAQ DQSFFTTLNA SSHGLVLHGL EPASLYHVCL
MASSKAGATN STSLTLMTLA LEESELHILL GLFGLLVLLI CLCGASRFCC RPSRKNPLWP
SVPDPAHSSL GSWVPTIMVE EAFQLPSLRD PGMPPITKIT VLEEEEKKPG PWESNDSSGT
CGLPTLVQAY VLQGDPRTPS TQPQPPSSTN DQVFYGQVLG SPTGPGPGHY LRCDSTQPLL
GGLTPSPKFY ENLWFQNSPL GTPEPLVPNQ EDDCVFGPLL DFPLLQGLQV HGVEGLGGI
//
