ID M3WIX2_FELCA Unreviewed; 1260 AA.
AC M3WIX2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Contactin associated protein family member 4 {ECO:0000313|Ensembl:ENSFCAP00000012499.6};
GN Name=CNTNAP4 {ECO:0000313|Ensembl:ENSFCAP00000012499.6,
GN ECO:0000313|VGNC:VGNC:61038};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000012499.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000012499.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012499.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000012499.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012499.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000012499.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012499.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WIX2; -.
DR Ensembl; ENSFCAT00000013481.6; ENSFCAP00000012499.6; ENSFCAG00000013476.6.
DR VGNC; VGNC:61038; CNTNAP4.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000157674; -.
DR HOGENOM; CLU_003504_1_0_1; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000013476; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR15036:SF40; CONTACTIN-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1260
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030174724"
FT TRANSMEM 1193..1217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..177
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 322..499
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 501..538
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 537..588
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 745..910
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 911..949
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 969..1154
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1139..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 883..910
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1260 AA; 139540 MW; 50A0919D38831061 CRC64;
MGSVAGAVLK TLLLLSTQNW NRVIAGNSYD CDEPLVSALS PASFSSSSEL SSSHGPGFAR
LNRRDGAGGW SPLVSNKYQW LQIDLGERME ITAVATQGGY GSSNWVTSYL LMFSDSGRNW
KQYRQEDSIW GFSGNANADS VVYYRLQPSI KARFLRFIPL EWNPRGRIGM RIEVFGCAYR
SEVVDLDGKS SLVYRFDQNS LSPIKDVISL KFKTMQSDGI LLHREGQNGD HITLDLRRGK
LFLLINSGET KLPSAHTLIN LTLGSLLDDQ HWHSVLIQRL GRQVNFTVDE HRHRFHAQGE
FSYLDLDYEG NVSFSCSQSQ SVPVTFLSPR SYLALPGFSG EDELSATFQF RTWNKAGLLL
FSELQLVSGG LLLFLNDGKL KLNLYQPGKL PSDITAGVGL NDGQWHSISL SAKRNHLSVV
VDGQVASVAS SLGSEQTYSG GTYYFGGCPD NSFGSKCKNP LGGFQGCMRL ISVSNKVVDL
ISVQQGSLGN FSDLQIDSCG ITDRCLPNYC EHGGECSQSW NTFHCNCANT GYTGATCHNS
IYEQSCESYK HRGNTSGFYY IDSDGSGPLE PFLLYCNMTE TAWTVIQHNG SDLTRVRNTN
PENPYAGFFE YVASMEQLQA TINLADHCEQ ELTYYCKKSR LANKQDGRPL SWWVGRTNET
QTYWGGSLPD PQKCTCGLEG NCIDSQYYCN CDADRNEWTN DTGFLSYKEH LPVRKIVVTD
TGRPHSEAAY KLGPLLCRGD RSFWNSASFN TEASYLHFPT FHGELSADVS FFFKTTASSG
VFLENLGITD FIRIELRSPA VVTFSFDVGN GPFEISVQSP THFNDNQWHH VKVERNMKEA
TIQVDQLLPK TQPAPTDGHV LLQLNSQLFV GGTATRQRGF LGCIRSLQLN GMSLDLEERA
KVTPGVEPGC RGHCSSYGKL CLNGGKCREK LSGFSCDCTF SAYTGPFCSK EISAYFGSGS
SVIYNFQENY SLSKNSSSHA ASFHGDMKLS REMIKFSFRT ARAPSLLLYV SSFYKEYLSV
IIAKNGDLQI RYKLNRYQEP DVVNFDFKNM ADGQLHHVEI NREEGVLFVE IDDNARRQVH
LSSGTELSAI KSLVLGRISE YNDVDQETAL AGAQGFLGCL SAVQLSHVAP LKAALQPSPP
APVTVSGHVT ESSCVSQAGT DATSRERTHS FADHSGTRDD REPLANAIRS DSAVIGGLIA
VVIFILLCIA AIAVRIYQQK RLYKRNEAKR SENVDSAEAV LKSELNIQSA VNENQKEYFF
//
