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Database: UniProt
Entry: M3WJ91_FELCA
LinkDB: M3WJ91_FELCA
Original site: M3WJ91_FELCA 
ID   M3WJ91_FELCA            Unreviewed;      2671 AA.
AC   M3WJ91;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 3.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSFCAP00000012667};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSFCAP00000012667};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000012667, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000012667, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012667,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000012667}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012667};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000012667}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012667};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
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DR   EMBL; AANG04003966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000012667; -.
DR   Ensembl; ENSFCAT00000013663; ENSFCAP00000012667; ENSFCAG00000013659.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000157078; -.
DR   InParanoid; M3WJ91; -.
DR   Proteomes; UP000011712; Chromosome B2.
DR   Bgee; ENSFCAG00000013659; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2201   2226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2238   2256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2268   2288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2324   2349       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2369   2391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2498   2521       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    372       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      378    434       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2629   2656       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2671 AA;  304064 MW;  1040F395E3A48122 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDTCES KAAGMRAQGR AGRRNAGEKI KYRLVAVPHG
     NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDIEEE RPIRLMLGTC
     PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLS EGFISQNDRR FVIQLLEDLV
     FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQIFG ILKAPFRDKG GEGPLVRLEE
     LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDPK
     NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA
     HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
     MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMDFVEDY
     LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA
     MLQAYDDSGG KNVRRSIQGV GHMMSTMVLS RKQSVFGAPS LPAGSGATEP LDRSKFEDNE
     DIVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSTT
     ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLI HLSMHDYAPL VSGALQLLFK
     HFSQRQEAIH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSSKGEEVE
     AGATKDKKER PTDEEGFLHP PGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM
     DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL HLFLTPGLLE
     AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM
     IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN
     VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL
     FENFTLDMAR VCSKREKRLA DPTLEKYVLT VVLDTINAFF SSPFSENSTS LQTHQTIVVQ
     LLQSTTRLLE CPWLQQQHKG SVEACIRTLA MVAKGRAISL PMDLDAHISS LLSSGTSCAA
     AAQRNASNYK ATTRAFPRVM PTANQWDYKN IIEKLQDIIT ALEERLRPLV QAELSVLVDV
     LHWPELLFLE GSEAYQRCES GGFLSKLIQH TKDLMESEEK LCVKVLRTLQ QMLLKKAKYG
     DRGNQLRKML LQNYLQNRKS SSRGDLPDPM SPGLDQDWSA IAATQCRLDK EGATKLVCDL
     ITSTKNEKIF QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET
     KSTVAVNMND LGSQPREDRE SADPTTKGRV ASFSMPGSPS RYSLGPSLRR GHEVGERVQS
     NEMGTSVLIM QPILRFLQLL CENHNRDLQN FLRSQNNKTN YNLVCETLQF LDIMCGSTTG
     GLGLLGLYIN EDNVGLVIQT LETLTEYCQG PCHENQTCIV THESNGIDII TALILNDISP
     LCKYRMDLVL QLKDNASKLL LALMESRHDS ENAERILISL RPQELVDVIK KAYLQEEERE
     NSEVSPREVG HNIYILALQL SRHNKQLQHL LKPVKRIQEE EAEGISSMLS LNNKQLSQML
     KSSAPAQEEE EDPLAYYENH TSQIEIVRQD RSMEQIVFPV PGICQFLTEE TKHRLFTTTE
     QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS MPLIYWFSRR MTLWGSISFN LAVFINIIIA
     FFYPYMEGAS TGVLGSPLIS LLFWILICFS IAALFTKRYS IRPLIVALIL RSIYYLGIGP
     TLNILGALNL TNKIVFVVSF VGNRGTFIRG YKAMVMDMEF LYHVGYILTS VLGLFVHELF
     YSILLFDLIY REETLFNVIK SVTRNGRSIL LTALLALILV YLFSIVGFLF LKDDFILEVD
     RLPGNHSGAS PLGMPHGAAT FVGTCSGDKL DCVSGVSVPE VLEGNEELES TERACDTLLM
     CIVTVMNHGL RNGGGVGDIL RKPSKDESLF PARVVYDLLF FFIVIIIVLN LIFGVIIDTF
     ADLRSEKQKK EEILKTTCFI CGLERDKFDN KTVSFEEHIK FEHNMWNYLY FIVLVRVKNK
     TDYTGPESYV AQMIKNKNLD WFPRMRAMSL VSNEGEGEQN EIRILQDKLN STMKLVSHLT
     AQLNELKEQM TEQRKRRQRL GFVDVQNCMS R
//
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