ID M3WM02_FELCA Unreviewed; 1172 AA.
AC M3WM02;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Laminin subunit beta 3 {ECO:0000313|Ensembl:ENSFCAP00000014037.5};
GN Name=LAMB3 {ECO:0000313|Ensembl:ENSFCAP00000014037.5,
GN ECO:0000313|VGNC:VGNC:68009};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000014037.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000014037.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014037.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000014037.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014037.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000014037.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014037.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; AANG04001043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019677441.1; XM_019821882.1.
DR AlphaFoldDB; M3WM02; -.
DR PaxDb; 9685-ENSFCAP00000014037; -.
DR Ensembl; ENSFCAT00000015136.6; ENSFCAP00000014037.5; ENSFCAG00000015132.6.
DR GeneID; 101088641; -.
DR KEGG; fca:101088641; -.
DR CTD; 3914; -.
DR VGNC; VGNC:68009; LAMB3.
DR eggNOG; KOG0994; Eukaryota.
DR GeneTree; ENSGT00940000160731; -.
DR HOGENOM; CLU_001560_0_0_1; -.
DR Proteomes; UP000011712; Chromosome F1.
DR Bgee; ENSFCAG00000015132; Expressed in tip of external ear and 10 other cell types or tissues.
DR CDD; cd22303; cc_LAMB3_C; 1.
DR CDD; cd00055; EGF_Lam; 6.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF268; LAMININ SUBUNIT BETA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 6.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 6.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1172
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016310035"
FT DOMAIN 22..249
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 250..315
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 316..378
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 379..430
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 431..480
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 481..533
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 534..580
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 839..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 949..1091
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 346..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 401..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 453..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 481..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 483..500
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 502..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 534..546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 536..553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 555..564
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1172 AA; 128589 MW; EB3A7757CB229A7A CRC64;
MRPLLLLGFV LPSFLCAQQA CSRGACYPPV GDLLIGRTRF LHASSTCGLT KPETYCTQYG
EWRMKCCKCD SRLPHNYNGH RVENVVSSSG PMRWWQSQND VNPVSLQLDL DRRFQLQDIM
MDFKGSLPAG MLIERSADFG NTWQVYQYLA ADCASVFPRV RQGQPQSWQD VRCQSLPQRP
NGHLDGGKVQ LNIMDLASGI PATQSQKIQE LGEITNLRIN FTRLAPVPQR GYHAPSAYYA
VSQLRLQGSC FCHGHADRCA PKPGASSSPS TAVQVHDICV CQHNTAGPNC ERCAPFYNNR
PWRPADDQDP HECQPCDCNG HSETCHFDPA VFAASQGAHG GVCDDCRDHT EGKNCERCQL
HYFRNRRPGA PIQETCIPCE CDPDGAVPGV PCDPVTGQCV CKEHVQGERC DLCKPGFTGL
TYANPQGCHR CDCNILGSHR DMPCDEESGH CLCLPHVVGP KCDQCAPYHW KLASGRGCEP
CACDPHNSLS PQCNQFTGQC PCREGFGGLT CDAAALRQCP DRTYGDTGTG CRACDCDFRG
TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCDRYPVCVA CHPCFQSYDA DLRGQALRLS
GLRNATASLW PGLGLEDPSL TARIMGAKSK MEQIQAILAS ASVTEQEVSQ VANAIFSIRR
TLQGLQPDLA LEEETLSLPG DLENLDRSFN RLLIIYQSKK EQFERLSSTD PLGALRVLTA
AYQRSSQAAQ QVSDGFHLLL QLRDSRREAE RLEGQVGGGT GAGGPQLAAL SLGMASLPDL
MPTINKLCGG SRQTACTPGA CPGELCPRDN GTACGSHCRG VLPKAGGAFR TAGQVARQLQ
GFNTQLQQTR QMIRAAEEAA SKVQSDAQRL ETQVSASRSQ MEEDVRRTRH LIQQVRDFLS
DPDTDAATIQ EVSEAVLALW LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS QTKKDIARAR
RLQAEAEQAR SRAHVVEGQV EDVVGNLRQG TVALQEAQDT MQGTSRSLRL IQERVAEVQQ
VLGPAERLVA GMTEQLGDFR ARMEALRLQA RQQRAQAAQA QQLAEGAEQQ ALSAQEGFER
IKQKYAELKD QLGRSPMLGE QGSRILSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI
ELRSADLTGL EKHVEQIRDH INGRVLYYAT CK
//
