ID M3WM40_FELCA Unreviewed; 455 AA.
AC M3WM40;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=BPI fold containing family B member 6 {ECO:0000313|Ensembl:ENSFCAP00000014082.4};
GN Name=BPIFB6 {ECO:0000313|Ensembl:ENSFCAP00000014082.4,
GN ECO:0000313|VGNC:VGNC:60159};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000014082.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000014082.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014082.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000014082.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014082.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000014082.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014082.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019683686.1; XM_019828127.1.
DR AlphaFoldDB; M3WM40; -.
DR STRING; 9685.ENSFCAP00000014082; -.
DR PaxDb; 9685-ENSFCAP00000014082; -.
DR Ensembl; ENSFCAT00000015185.5; ENSFCAP00000014082.4; ENSFCAG00000015181.5.
DR GeneID; 101092260; -.
DR KEGG; fca:101092260; -.
DR CTD; 128859; -.
DR VGNC; VGNC:60159; BPIFB6.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01100000263546; -.
DR HOGENOM; CLU_031635_1_0_1; -.
DR InParanoid; M3WM40; -.
DR OMA; PKVTMKT; -.
DR OrthoDB; 5320546at2759; -.
DR Proteomes; UP000011712; Chromosome A3.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR46019; BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED; 1.
DR PANTHER; PTHR46019:SF2; BPI FOLD-CONTAINING FAMILY B MEMBER 6; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..455
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016390996"
FT DOMAIN 22..231
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
FT DOMAIN 251..450
FT /note="Lipid-binding serum glycoprotein C-terminal"
FT /evidence="ECO:0000259|SMART:SM00329"
SQ SEQUENCE 455 AA; 49779 MW; 49E183C245BBD153 CRC64;
MLRILFLALC GLLTHTRADP GALLRLGLDI MNQVQSAMDE SHILEQMAAE AGKKQPGMKP
IKGITNLKVK DVQLPVITLS FLPGVGIFQC VSTGMTITGK SFIGGNMEII VVLNITATNR
LLQDEKTGLP TFKSEGCEVI LVSVKTNLPS NMLPKVVNKF LDSTLHKVLP SLMCPAIDAV
LVYVNRKWAN LNAPMPVGQM GIVKYVLTSM PTTTANYLQV AFSPVVQQQE GNTIQPADAG
EALEFPEGYA EGSSQLLLSA TFLTTGLALL QKSFNVTIQD MKIGKLPPQT TKTLAGFIPK
VAKAYPKPKP LVTQIRINKP PKVTMKTGKS LLHLHGTLEM FAARRRGKAP VSLFLLETHF
NLKIQYSVRE DRLLMLTSLD RLLSLSRESS SIGAFSEKEL TGFITDYLQE AYVPVVNDVL
QVGFPLPDLL DIDYNLAEPD IVENALVLVL DLKLD
//
