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Database: UniProt
Entry: M3WMG1_FELCA
LinkDB: M3WMG1_FELCA
Original site: M3WMG1_FELCA 
ID   M3WMG1_FELCA            Unreviewed;       319 AA.
AC   M3WMG1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 2.
DT   16-OCT-2019, entry version 50.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000014240};
GN   Name=SPDEF {ECO:0000313|Ensembl:ENSFCAP00000014240,
GN   ECO:0000313|VGNC:VGNC:65628};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000014240, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000014240, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014240,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000014240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014240};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000014240}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014240};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AANG04003966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000014240; -.
DR   Ensembl; ENSFCAT00000015360; ENSFCAP00000014240; ENSFCAG00000015357.
DR   VGNC; VGNC:65628; SPDEF.
DR   eggNOG; KOG3805; Eukaryota.
DR   eggNOG; ENOG410XSXU; LUCA.
DR   GeneTree; ENSGT00940000157549; -.
DR   InParanoid; M3WMG1; -.
DR   OrthoDB; 908495at2759; -.
DR   Proteomes; UP000011712; Chromosome B2.
DR   Bgee; ENSFCAG00000015357; Expressed in 1 organ(s), highest expression level in liver.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0060576; P:intestinal epithelial cell development; IEA:Ensembl.
DR   GO; GO:0060480; P:lung goblet cell differentiation; IEA:Ensembl.
DR   GO; GO:0010454; P:negative regulation of cell fate commitment; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0010455; P:positive regulation of cell fate commitment; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT   DOMAIN      129    213       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      233    316       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION       29     50       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       73    102       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   319 AA;  35518 MW;  9C68CF16D029BE2B CRC64;
     MGSASPGLSS VAPGRLLLPP DAVLRTGVEK AAAGAVGPER RDWSPSPPAT PDQGLSAFYL
     SYFDMLYPED GNWATKGPGA SSREEPPEEP EQCPVIDSQA PGGSLDLAPG SLTLEEHSLE
     QVQSMVVGEV LKDIETACKL LNITADPVDW SPGNVQKWLL WTEHQYRLPP VGKAFQELGG
     KELCAMSEEQ FRQRSPLGGD VLHAHLDIWK SASTSEDSWT DSEVDSSCSG QPIHLWQFLK
     ELLLKPHSYG RFIRWLNKEK GIFKIEDSAQ VARLWGIRKN RPAMNYDKLS RSIRQYYKKG
     IIRKPDISQR LVYQFVHPI
//
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