ID M3WMT5_FELCA Unreviewed; 1119 AA.
AC M3WMT5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Adhesion G protein-coupled receptor A2 {ECO:0000313|Ensembl:ENSFCAP00000014409.4};
GN Name=ADGRA2 {ECO:0000313|Ensembl:ENSFCAP00000014409.4,
GN ECO:0000313|VGNC:VGNC:59628};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000014409.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000014409.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014409.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000014409.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014409.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000014409.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014409.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WMT5; -.
DR Ensembl; ENSFCAT00000015540.5; ENSFCAP00000014409.4; ENSFCAG00000015536.5.
DR VGNC; VGNC:59628; ADGRA2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158941; -.
DR HOGENOM; CLU_005242_0_0_1; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000015536; Expressed in eyeball of camera-type eye and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15998; 7tmB2_GPR124; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR A2; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1119
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016446446"
FT TRANSMEM 554..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 259..343
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 326..420
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 551..726
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 870..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..968
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1119 AA; 119726 MW; D28EECE9CA41EEB3 CRC64;
MGAAGRRMRG APARLLLPLL PWLLLLAPET RGAPGCPVPI RSCKCSGERP KGLSGGAPNP
ARRRVVCGGG DLPEPPEPGL LPNGTVTLLL SNNKITGLRN GSFLGLSLLE KLDLRNNVIS
TVHPGAFLGL GELKRLDLSN NRIGCLTSET FQGLPRLLRL NISGNIFSSL QPGVFDELPA
LKVVDLGTEY LTCDCRLRWL LSWARNRSLQ LSEHTLCAYP GALHAQALGG LQEAQLRCEG
ALELHTHHLI PSLRQVVFQG DRLPFQCSAS YLGEDTRIRW YHNRAPLEGD EQAGILLAES
LIHDCTFITS ELTVSHIGVW ASGEWECSVS TAQGNASKKV EIVVLETSAS YCPAERVANN
RGDFRWPRTL AGITAYQSCL QYPFTSVPLS GGAPGTRASR RCDRAGRWEP GDYSHCLYTN
DITRVLYTFV LMPINASNAL TLAHQLRVYT AEAASFSDMM DVVYVAQMIQ KFLGYVDQIK
ELVEVMVDMA SNLMLVDEHL LWLAQREDKA CSGIVGALER IGGAALSPHA QHISVELSAF
PREVGGSGAG LHPVVYPCTA LLLLCLFSTI ITYILNHSSI HVSRKGWHML LNLCFHMAMT
SAVFAGGITL TNYPTVCQAV GVTLHYSSLS TLLWMGVKAR VLHKELTWRA PPPQEGDSAP
PAPRPMLRFY LIAGGIPLII CGITAAVNIH NYRDHSPYCW LVWRPSLGAF YIPVALILLI
TWIYFLCAGL RLRGPLAQSP KGGTSRVSLE PGEELRASTR LRSSGPFLND SGSLLATGSA
GVVTPGPPED GDGLYSPGVQ LGALVTTHFL YLAMWACGAL AVSQRWLPRV VCSCLYGVAA
SALGLFVFTH HCARRRDVRA SWRACCPHAS APGASPRAVP AASEDGSPVF GEGPPSLKSS
PSGSSGHAPP LGPCKLTNLQ VAQSQVCEAG VVSRGEGEPE PTGSRGSLAP RHANNLHHGR
RVHKSRVKGH RAGEAGSKNR LKALRGGAAA GAPELLSSES GSLHNSPSDS YPGSSRNSPG
LQLEGEPMLT PSEGSDTSAA PPPEVGRPGQ RRSASRDNLK GGGGGALERE SKRRSYPLNA
ASLNGAPKGA KYDDITMTGT EAAGGACMKT GLWKSETTV
//