ID M3WNC5_FELCA Unreviewed; 908 AA.
AC M3WNC5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=DEAD/H-box helicase 11 {ECO:0000313|Ensembl:ENSFCAP00000015131.4};
GN Name=DDX11 {ECO:0000313|Ensembl:ENSFCAP00000015131.4};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000015131.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000015131.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015131.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000015131.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015131.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000015131.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015131.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR EMBL; AANG04001873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011282043.1; XM_011283741.2.
DR RefSeq; XP_019689912.1; XM_019834353.1.
DR AlphaFoldDB; M3WNC5; -.
DR STRING; 9685.ENSFCAP00000015131; -.
DR PaxDb; 9685-ENSFCAP00000015131; -.
DR Ensembl; ENSFCAT00000016281.6; ENSFCAP00000015131.4; ENSFCAG00000016277.6.
DR GeneID; 101097815; -.
DR KEGG; fca:101097815; -.
DR CTD; 1663; -.
DR eggNOG; KOG1133; Eukaryota.
DR GeneTree; ENSGT00950000182970; -.
DR HOGENOM; CLU_006515_2_1_1; -.
DR InParanoid; M3WNC5; -.
DR OMA; QTHQFRD; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000016277; Expressed in embryonic head and 9 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0031390; C:Ctf18 RFC-like complex; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008186; F:ATP-dependent activity, acting on RNA; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:Ensembl.
DR GO; GO:0051880; F:G-quadruplex DNA binding; IEA:Ensembl.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0045142; F:triplex DNA binding; IEA:Ensembl.
DR GO; GO:1904976; P:cellular response to bleomycin; IEA:Ensembl.
DR GO; GO:0072719; P:cellular response to cisplatin; IEA:Ensembl.
DR GO; GO:0072711; P:cellular response to hydroxyurea; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0034085; P:establishment of sister chromatid cohesion; IBA:GO_Central.
DR GO; GO:0044806; P:G-quadruplex DNA unwinding; IEA:Ensembl.
DR GO; GO:1990700; P:nucleolar chromatin organization; IEA:Ensembl.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0045876; P:positive regulation of sister chromatid cohesion; IEA:Ensembl.
DR GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 9..446
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 82..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 130..180
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 908 AA; 102492 MW; FB26C6FFEDFBE016 CRC64;
MANKTQEDGG IHFPFPFTPY SIQKDFMAEL YRVLDAGKIG IFESPTGTGK SLSLICGALS
WLRDFEQKKH QEEARLLETG TVPLSDGKDQ PPFLSSSCKE TPDTLRPAGE PDWVTQFVQK
KEERDLVDRL KEEQVRRKKR EERLQQIRHN AQLKYAAKRM RREEEEMERL LHLSREMLAE
GTGTEPLEQL VCGDEELVLA EYESDEEKGA ARGVDEEEEE EDLEEEHVTK IYYCSRTHSQ
LAQFVHEVQR SPFGKDTRLV SLGSRQNLCI NEDVKNLGSA QLINDRCMEM QRSKHEKSRA
EDEKPKRRRQ EHQAACPFYS YEQLQLLRDE VLVGVKDIEQ LVSLGKEARA CPYYGSRFAI
PAAQLVVLPY QMLLHGATRQ AAGIRLQGQV VVIDEAHNLI DTITGIYSAE VSGSQFCQAH
SQLLQYMERY GKRLKAKNLM YIKQLLYLLE QFVTVLGGNI KQNPNTQSLS QTGTELKTIN
DFLFQSQIDN INLFKVRRYC EKSMVSRKLF GFTERYGTVL ASSREQSRLA GFQHFLQSLQ
PALTETPVPH GDEGEARVPR SASPLMHIEG FLAALTTANQ DGRVILNRQG SLSLSSLKFL
LLNPAVHFAQ VVKECRAVVI AGGTMQPVSD FREQLLACAG VEAERVVEFS CGHVIPPDNI
LPLVICSGPS SQQLEFTYQK RELPQMMDET GRILYNLCNV VPGGVVCFFP SYEYQRQVHA
HWDKSGLLAR LAVRKKIFQE PKRANQVEQV LLEYSRCIKC CGHAGGAVTG ALLLSVVGGK
MSEGINFSDD LGRCVVMVGM PYPNIKSPEL QEKMAYLDQT LPRIPGQPPP GKALVENLCM
KAVNQSIGRA IRHQKDFASI VLLDHRYARP PVLGKLPAWI RDRVEVKATF GPAFAAMRKF
HRERPGPS
//
