ID M3WNN1_FELCA Unreviewed; 497 AA.
AC M3WNN1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Beta-1,4-N-acetyl-galactosaminyltransferase 2 {ECO:0000313|Ensembl:ENSFCAP00000015492.4};
GN Name=B4GALNT2 {ECO:0000313|VGNC:VGNC:60063};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000015492.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000015492.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015492.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000015492.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015492.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000015492.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015492.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; AANG04003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WNN1; -.
DR PaxDb; 9685-ENSFCAP00000015492; -.
DR Ensembl; ENSFCAT00000018222.5; ENSFCAP00000015492.4; ENSFCAG00000018523.5.
DR VGNC; VGNC:60063; B4GALNT2.
DR eggNOG; ENOG502QTK7; Eukaryota.
DR GeneTree; ENSGT00390000006679; -.
DR HOGENOM; CLU_036051_1_0_1; -.
DR InParanoid; M3WNN1; -.
DR OMA; GDCIHRR; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000018523; Expressed in uterus and 2 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008376; F:acetylgalactosaminyltransferase activity; IBA:GO_Central.
DR GO; GO:0030259; P:lipid glycosylation; IEA:InterPro.
DR GO; GO:0022408; P:negative regulation of cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0006486; P:protein glycosylation; IEA:Ensembl.
DR GO; GO:0017038; P:protein import; IEA:Ensembl.
DR GO; GO:0098528; P:skeletal muscle fiber differentiation; IEA:Ensembl.
DR GO; GO:0043403; P:skeletal muscle tissue regeneration; IEA:Ensembl.
DR GO; GO:0019276; P:UDP-N-acetylgalactosamine metabolic process; IBA:GO_Central.
DR GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IBA:GO_Central.
DR CDD; cd00761; Glyco_tranf_GTA_type; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR011143; GM2_synthase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR15046:SF2; BETA-1,4 N-ACETYLGALACTOSAMINYLTRANSFERASE 2; 1.
DR PANTHER; PTHR15046; GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR PIRSF; PIRSF000474; GM2_GD2_synthase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 261..367
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
SQ SEQUENCE 497 AA; 56204 MW; E7810E5311CBB2DF CRC64;
MPWCRCEFLR LLKISAFLLG LGTIGFLCLS VGLSRLTPEL PPSAVADQPP KLLPEERLRN
LFTYDGIWLF PKNQCKCEAP KGQGGYNFQD AFGQSELPAV KARRRAEFEH FQRRERLPRS
PPLLAQPNLP FGYPVHGVEV MPLHTVPLPG LQFEGQDAPF YKVTLTASLG TLNTLADVPD
SVVQGRGQKQ LTVSTSNRQL LNFVLQHLTY TSTVYQHPRV DVVSLESKSS VARFPVTIRH
PVMPRLYDPG PERKLRDLVT IATKTFLRPH KLMTMLRSIR EFYPDLTVIV ADDSKEPLKI
NDDHVEYYTM PFGKGWFAGR NLAISQVATK YVLWVDDDFL FNDKTKIEVL VDVLEKTELD
VVGGSVLGNV FQFKLLLERS QNGDCLHRRP GSFGPLDGFP RCVVTSGVVN FFLAHTERLQ
RVGFDPRLRR VAHSEFFIDG LGSLLVGSCP EVIIGHQARS PAADLEKMYS TFRTNTHDQI
QFKLALHYFK NHLQCST
//
