ID M3WNT8_FELCA Unreviewed; 580 AA.
AC M3WNT8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Protein disulfide isomerase like, testis expressed {ECO:0000313|Ensembl:ENSFCAP00000015613.2};
GN Name=PDILT {ECO:0000313|Ensembl:ENSFCAP00000015613.2,
GN ECO:0000313|VGNC:VGNC:64088};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000015613.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000015613.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015613.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000015613.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015613.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000015613.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000015613.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000256|ARBA:ARBA00006347}.
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DR EMBL; AANG04001668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003998839.1; XM_003998790.3.
DR AlphaFoldDB; M3WNT8; -.
DR STRING; 9685.ENSFCAP00000015613; -.
DR PaxDb; 9685-ENSFCAP00000015613; -.
DR Ensembl; ENSFCAT00000018883.5; ENSFCAP00000015613.2; ENSFCAG00000018103.5.
DR GeneID; 101083990; -.
DR KEGG; fca:101083990; -.
DR CTD; 204474; -.
DR VGNC; VGNC:64088; PDILT.
DR eggNOG; KOG0191; Eukaryota.
DR GeneTree; ENSGT00940000160939; -.
DR HOGENOM; CLU_025879_1_1_1; -.
DR InParanoid; M3WNT8; -.
DR OMA; APWSKKC; -.
DR OrthoDB; 5399045at2759; -.
DR Proteomes; UP000011712; Chromosome E3.
DR Bgee; ENSFCAG00000018103; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IEA:Ensembl.
DR GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd02961; PDI_a_family; 1.
DR CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR CDD; cd02982; PDI_b'_family; 1.
DR CDD; cd02981; PDI_b_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR PANTHER; PTHR18929:SF58; PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 4.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..580
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004042521"
FT DOMAIN 381..494
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 536..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 66596 MW; 333ADC46B77F4C53 CRC64;
MELLWISLLL AASRGSTVQG FPEEDVKEAS INISQPLHIV EEGNLLVLTP AGLTQMLNQT
RFLMVLFHNP SSKQSRSLAE ELGKAVEIMG KGKNGLGFGK ADITVEKELQ TEFNVKEAPE
LKLFFEGNRS EPISCKGVVE STALVVWLRR QISQKAFLFN NTQQVLDFVK SRPLVIIGFF
QDLEEEVAEL FYDVIKDFPE LTFGVISISN AIGRFHVTLD SLLVFKKGKI VNREELINDS
TNKQVLNQVI KQHLTDFVIE YNTESKDLIY ELHILNHMLL FASKRSESFG MIMQHYKLAS
KEFTNKILFI IVDADEPRNG HIFKYFRITE VNIPCVQILN LSSDARYKMP SEEITYENLK
KFGRSFLNRS AKKHQSSEEI PKYWDQGPVK QLVGKNFNVV VFDKERDVFV MFYAPWSEKC
KELFPVLQEL GRKYQNHSTV TIAKIDIMAN DIQLMYLDRY PFFRLFPTDS QQAVVYKGEH
TLKGFSDFLE TQIKTRIEDE DGLLSTEQSK VTEEEALAEK KEVPIIKKEL RDQKLPGIEN
VTKLEEPAGQ KEPAKEEEEK VAKPKGPPKE EKKPKVKEEL
//
