ID M3WPI9_FELCA Unreviewed; 1086 AA.
AC M3WPI9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSFCAP00000016151.3};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSFCAP00000016151.3,
GN ECO:0000313|VGNC:VGNC:63524};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016151.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000016151.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016151.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000016151.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016151.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000016151.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016151.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006933353.1; XM_006933291.3.
DR RefSeq; XP_006933354.1; XM_006933292.3.
DR RefSeq; XP_019689590.1; XM_019834031.1.
DR RefSeq; XP_019689591.1; XM_019834032.1.
DR AlphaFoldDB; M3WPI9; -.
DR PaxDb; 9685-ENSFCAP00000016151; -.
DR Ensembl; ENSFCAT00000018177.5; ENSFCAP00000016151.3; ENSFCAG00000018749.5.
DR GeneID; 101095180; -.
DR KEGG; fca:101095180; -.
DR CTD; 8028; -.
DR VGNC; VGNC:63524; MLLT10.
DR eggNOG; KOG0956; Eukaryota.
DR GeneTree; ENSGT00940000157711; -.
DR HOGENOM; CLU_010286_1_0_1; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000018749; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 22..74
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 79..198
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 134..197
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 206..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 757..794
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 338..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1086 AA; 115337 MW; D946AB84D1EE41FE CRC64;
MVSSDRPVSL EDEVSHSMKE MIGGCCVCSD ERGWAENPLV YCDGHGCSVA VHQACYGIVQ
VPTGPWFCRK CESQERAARV RCELCPHKDG ALKRTDNGGW AHVVCALYIP EVQFANVSTM
EPIVLQSVPH DRYNKTCYIC DEQGRESKAA TGACMTCNKH GCRQAFHVTC AQFAGLLCEE
EGNGADNVQY CGYCKYHFSK LKKSKRGSNR SYDQSLSDSS SHSQDKHHEK EKKKYKEKDK
HKQKHKKQPE PSPALVPSLT VTTEKTYTST SSNSISGSLK RLEDTAARFT NANFQEVSAH
TTSGKDVSEA RGSEGKGKKS SAHSSGQRGR KPGGRNPGTT VSAASPFQQG SFSGTPGSVK
SSSGSSVQSP QDFLSFTDSD LRNDSYTHSQ QSSSTKDVHK GESGSQEGGV NSFSSIMGLP
STSAVISQPK SFENSPGDLG NSSLPTAGYK RAQTSGIEEE TVKEKKRKGS KQSKHGPGRP
KGNKNQENVS HLSVSSASPT SSVASAAGSV TSSSLQKSPT LLRNGSLQSL SVGSSPVGSE
ISMQYRHDGA CPTATFSELL NAIHNDRDDS STLTKQELKF IGIYNSNDVA VSFPNVVSGS
GSSTPVSSSH LPQQSSGHLQ QVGALSPSAA SSAAPAVATT QANTLSGSSL SQAPSHMYGN
RLNPNSSMAA LIVQSENSQT DQDLGDNGRS LAGRGSSPRG SLSPRSPVSS LQIRYDQPVN
SSLENLPPVA ASIEQLLERQ WSEGQQFLLE QGTPSDILGM LKSLHQLQVE NRRLEEQIKN
LTAKKERLQL LNAQLSVPFP TITTNPSPSH QMHAFSAQNA PTTDSLNSSK SPHLGNSFLP
DNSLPVLNQD LTSSGQSTSS SSALSTPPPA GQSPAQPGSG VSGVQQVNGV TVGALAGGMQ
TVTSTIPAVP GVGGIIGALP GNQLAINGIV GALNGVIQTP VTISQNPTPL THTTVPPNAT
HPMPATLTNS ASGLGLLSDQ QRQIYLHQQQ FQQLLNSQQL TPEQHQALLY QLMQQHHHQQ
HHQPELQQLQ MPGPTQIPIN NLLAGTQAPP LHPATTNPFL TIHGDGASQK VTRLSDKTGP
VTQEKS
//
