ID M3WPK1_FELCA Unreviewed; 486 AA.
AC M3WPK1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Sorting nexin 6 {ECO:0000313|Ensembl:ENSFCAP00000016175.5};
GN Name=SNX6 {ECO:0000313|Ensembl:ENSFCAP00000016175.5,
GN ECO:0000313|VGNC:VGNC:80838};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016175.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000016175.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016175.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000016175.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016175.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000016175.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016175.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AANG04004459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WPK1; -.
DR STRING; 9685.ENSFCAP00000016175; -.
DR PaxDb; 9685-ENSFCAP00000016175; -.
DR Ensembl; ENSFCAT00000018857.5; ENSFCAP00000016175.5; ENSFCAG00000018851.5.
DR VGNC; VGNC:80838; SNX6.
DR eggNOG; KOG1660; Eukaryota.
DR GeneTree; ENSGT00940000154940; -.
DR HOGENOM; CLU_040966_0_0_1; -.
DR InParanoid; M3WPK1; -.
DR OMA; CEKFEQM; -.
DR Proteomes; UP000011712; Chromosome B3.
DR Bgee; ENSFCAG00000018851; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0097422; C:tubular endosome; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IEA:Ensembl.
DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR CDD; cd07662; BAR_SNX6; 1.
DR CDD; cd07292; PX_SNX6; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR028657; BAR_SNX6.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042136; PX_SNX6.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR45850:SF4; SORTING NEXIN-6; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 107..254
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 28..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 54537 MW; C7DC07685BE4A49F CRC64;
MWVWAFGAFP TRVLRPWAEG PAFLFPTAHG PRPSAPGRGG AGCSEAPPPP AATSPAPPAA
AGSLRPRGAV RACAGPRLGA AMMEGLDDGP DFLSEEDRGL KAINVDLQSD AALQVDISDA
LSERDKVKFT VHTKSSLPNF KQNEFSVVRQ HEEFIWLHDS FVENEDYAGY IIPPAPPRPD
FDASREKLQK LGEGEGSMTK EEFTKMKQEL EAEYLAIFKK TVAMHEVFLC RVAAHPILRK
DLNFHVFLEY NQDLSVRGKN KKEKLEDFFK NMVKSADGVI VSGVKDVDDF FEHERTFLLE
YHNRVKDASA KSDRMTRSHK SAADDYNRIG SSLYALGTQD STDICKFFLK VSELFDKTRK
IEARVSADED LKLSDLLKYY LRESQAAKDL LYRRSRSLVD YENANKALDK ARAKNKDVLQ
AETSQQLCCQ KFEKISESAK QELIDFKTRR VAARKNLVEL AELELKHAKG NLQLLQNCLA
VLNGDT
//
